Results 81 to 90 of about 10,658,834 (304)

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Fractional-Order LCL Filters: Principle, Frequency Characteristics, and Their Analysis

Fractal and Fractional
The fractional-order LCL filter, composed of two fractional-order inductors and one fractional-order capacitor, is a novel fractional-order π-type circuit introduced in recent years.
Junhua Xu, Ermeng Zeng, Xiaocong Li, Guopeng He, Weixun Liu, Xuanren Meng   +5 more
doaj   +1 more source

Identification of a Shiga toxin A‐derived peptide internalized into Gb3 receptor‐bearing cells via interaction with the Shiga toxin B subunit

FEBS Letters, EarlyView.
The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi, João C. Encarnação, Valeria Napolitano, Grzegorz Dubin, Grzegorz Popowicz, Karl Andersson, U. Helena Danielson   +6 more
wiley   +1 more source

Novel fractional order SIDARTHE mathematical model of COVID-19 pandemic

Chaos, Solitons & Fractals, 2020
Highlights • COVID-19 pandemic is modeled via the fractional order SIDARTHE mathematical model.• The solution existence of the proposed COVID-19 pandemic fractional order SIDARTHE mathematical model is proved.• Four optimal control plans are produced and
M. Higazy
semanticscholar   +1 more source

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source

Analysis of Caputo fractional-order model for COVID-19 with lockdown

Advances in Differential Equations, 2020
One of the control measures available that are believed to be the most reliable methods of curbing the spread of coronavirus at the moment if they were to be successfully applied is lockdown.
Idris Ahmed, I. Baba, A. Yusuf, Poom Kumam, W. Kumam   +4 more
semanticscholar   +1 more source

Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions

FEBS Letters, EarlyView.
The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang, Hyo Been Jin, Chang Min Kim, So Yeon Lee, Hyun Ho Park   +4 more
wiley   +1 more source

Comparison of Fractional Order Modelling and Integer Order Modelling of Fractional Order Buck Converter in Continuous Condition Mode Operation

Advances in Electrical and Electronic Engineering, 2016
Producing a mathematical model with high accuracy is the first and important step in control of systems. Nowadays fractional calculus has been in the spotlight and it has a lot of application especially in control engineering. Fractional modelling on one
Ali Moshar Movahed, Heydar Toossian Shandiz, Syed Kamal Hosseini Sani   +2 more
doaj   +1 more source

AscF in the mycobacterial CIII–CIV supercomplex lacks metal and nucleotide binding but links malate oxidation to respiration

FEBS Letters, EarlyView.
The mycobacterial CIII‐CIV respiratory supercomplex is an obligate assembly, encompassing several subunits of unknown functions. We have characterized the intracellular subunit AscF, and show that it is unlikely to be a sensor for metals or nucleotides, but is required for growth on nonfermentable energy sources, and likely works as an adapter for ...
Eni Rile, Riccardo Diamanti, Daniel Lundin, Soni Sharma, Robin Lissner, Coenraad P. Kuil, Martin Högbom, Dirk Bald, Dan Sjöstrand   +8 more
wiley   +1 more source