Results 71 to 80 of about 26,243 (274)

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

open access: yesFEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li   +2 more
wiley   +1 more source

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

open access: yesFEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee   +3 more
wiley   +1 more source

Structural biology of ferritin nanocages

open access: yesFEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source

Control and Synchronization of Fractional-Order Financial System Based on Linear Control

open access: yesDiscrete Dynamics in Nature and Society, 2011
Control and synchronization of the financial systems with fractional-order are discussed in this paper. Based on the stability theory of fractional-order differential equations, Routh-Hurwitz stability condition, and by using linear control, simpler ...
Liping Chen, Yi Chai, Ranchao Wu
doaj   +1 more source

Hybrid Systems and Control With Fractional Dynamics (II): Control

open access: yes, 2014
No mixed research of hybrid and fractional-order systems into a cohesive and multifaceted whole can be found in the literature. This paper focuses on such a synergistic approach of the theories of both branches, which is believed to give additional ...
HosseinNia, S. Hassan   +2 more
core   +1 more source

β‐TrCP overexpression enhances cisplatin sensitivity by depleting BRCA1

open access: yesMolecular Oncology, EarlyView.
Low levels of β‐TrCP (Panel A) allow the accumulation of BRCA1 and CtIP, which facilitate the repair of cisplatin‐induced DNA damage via homologous recombination (HR) and promote tumor cell survival. In contrast, high β‐TrCP expression (Panel B) leads to BRCA1 and CtIP degradation, impairing HR repair, resulting in persistent DNA damage and apoptosis ...
Rocío Jiménez‐Guerrero   +8 more
wiley   +1 more source

Design and Comparison of Fractional-Order Controllers in Flotation Cell Banks and Flotation Columns Used in Copper Extraction Processes

open access: yesMathematics
This work explores efficiency improvements in the copper flotation stage, a complex nonlinear, multivariable process subject to numerous perturbations.
Manuel A. Duarte-Mermoud   +3 more
doaj   +1 more source

Bifurcations and Synchronization of the Fractional-Order Bloch System

open access: yesDiscrete Dynamics in Nature and Society, 2017
In this paper, bifurcations and synchronization of a fractional-order Bloch system are studied. Firstly, the bifurcations with the variation of every order and the system parameter for the system are discussed.
Xiaojun Liu   +3 more
doaj   +1 more source

Integrated genomic and proteomic profiling reveals insights into chemoradiation resistance in cervical cancer

open access: yesMolecular Oncology, EarlyView.
A comprehensive genomic and proteomic analysis of cervical cancer revealed STK11 and STX3 as a potential biomarkers of chemoradiation resistance. Our study demonstrated EGFR as a therapeutic target, paving the way for precision strategies to overcome treatment failure and the DNA repair pathway as a critical mechanism of resistance.
Janani Sambath   +13 more
wiley   +1 more source

Electronic realization of the fractional-order systems [PDF]

open access: yes, 2007
This article is devoted to the electronic (analogue) realization of the fractional-order systems – controllers or controlled objects whose we earlier used, identified, and analyzed as a mathematical models only namely a fractional-order differential ...
Františka Dorčáková   +3 more
core  

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