Results 61 to 70 of about 10,729,116 (245)
Design and analysis strategies for robust microbiome ageing research
FEBS Letters, EarlyView.The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik +5 more
wiley +1 more source
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
Fractal and FractionalConventional integer-order parameter designs of grid-forming inverters provide limited degrees of freedom for impedance adjustment, motivating the exploration of additional approaches for flexible impedance reshaping across different frequency ranges ...
Junhua Xu +4 more
doaj +1 more source
FEBS Letters, EarlyView.The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi +6 more
wiley +1 more source
Oscillators Based on Fractional-Order Memory Elements
Fractal and Fractional, 2022 This paper deals with the new oscillator structures that contain new elements, so-called memory elements, known as memristor, meminductor, and memcapacitor. Such circuits can exhibit oscillations as well as chaotic behavior. New mathematical models of fractional-order elements and whole oscillator circuits are proposed as well.
openaire +2 more sources
Fractional boundary value problems: Analysis and numerical methods [PDF]
, 2011 This is the author's PDF of an article published in Fractional Calculus and Applied Analysis 2011. The original publication is available at www.springerlink.comThis journal article discusses nonlinear boundary value problems.Fundacao para a Ciencia e ...
M. Luísa Morgado +3 more
core +1 more source
Investigating transcription factor dynamics in health and disease using FRAP
FEBS Letters, EarlyView.FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj +3 more
wiley +1 more source
Various Methods of Realization for Fractional-Order Elements
ECTI Transactions on Electrical Engineering, Electronics, and Communications, 2023 Fractional-order circuits are finding applications in control systems, signal processing, and other allied fields. As a result, realizing fractional-order elements or fractance devices is an essential research topic. A unique fractance device is realized in this study using continued fraction expansion (CFE) and partial fraction expansion (PFE ...
openaire +1 more source
Fractional variational problems with the Riesz-Caputo derivative [PDF]
, 2012 In this paper we investigate optimality conditions for fractional variational problems, with a Lagrangian depending on the Riesz-Caputo derivative. First we prove a generalized Euler-Lagrange equation for the case when the interval of integration of the ...
Almeida, R. +2 more
core +1 more source
Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions
FEBS Letters, EarlyView.The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang +4 more
wiley +1 more source