Results 81 to 90 of about 230,985 (278)

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

Molecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson, Lyanne Delgado‐Coka, Natalia Marchenko, Luisa F. Escobar‐Hoyos, Kenneth R. Shroyer, Alisa Yurovsky, Trey Ideker, Gábor Balázsi, Thomas MacCarthy, Scott Powers   +9 more
wiley   +1 more source

A Discrete Method Based on the CE-SE Formulation for the Fractional Advection-Dispersion Equation

Discrete Dynamics in Nature and Society, 2015
We obtain a numerical algorithm by using the space-time conservation element and solution element (CE-SE) method for the fractional advection-dispersion equation. The fractional derivative is defined by the Riemann-Liouville formula. We prove that the CE-
Silvia Jerez, Ivan Dzib
doaj   +1 more source

Enhance limit cycle oscillation in a wind flow energy harvester system with fractional order derivatives

Theoretical and Applied Mechanics Letters, 2014
Advances in material science and mathematics in conjunction with technological needs have triggered the use of material and electric components with fractional order physical properties. This paper considers the mathematical model of a piezoelectric wind
Cedrick A. Kitio Kwuimy, Grzegorz Litak
doaj   +1 more source

Identifying codes in vertex-transitive graphs and strongly regular graphs [PDF]

, 2015
We consider the problem of computing identifying codes of graphs and its fractional relaxation. The ratio between the size of optimal integer and fractional solutions is between 1 and 2ln(vertical bar V vertical bar) + 1 where V is the set of vertices of
Gravier, Sylvain, Parreau, Aline, Rottey, Sara, Storme, Leo, Vandomme, Élise   +4 more
core   +1 more source

Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma

Molecular Oncology, EarlyView.
The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic, Anne Nørremølle, Lilian Bomme Ousager, Lars van Brakel Andersen, Marie Louise Mølgaard Binderup, Mads Thomassen   +5 more
wiley   +1 more source

A Creep Model of Asphalt Mixture Based on Variable Order Fractional Derivative

Applied Sciences, 2020
In order to quantitatively describe the time-varying mechanical properties of asphalt mixture during creep process, a nonlinear viscoelastoplastic creep model was proposed, by using variable-order fractional calculus.
Wenbo Luo, Bo Li, Yongjun Zhang, Boyuan Yin, Jingling Dai   +4 more
doaj   +1 more source

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

Equivalent diagrams of fractional order elements

Archives of Control Sciences
This paper presents equivalent impedance and operator admittance systems for fractional order elements. Presented models of fractional order elements of the type: s α L α and 1/s α C α, (0 α 1) were obtained using the Laplace transform based on the expansion of the factor sign to an infinite fraction with varying degrees of accuracy – the continued ...
Sebastian Różowicz, Maciej Włodarczyk, Andrzej Zawadzki   +2 more
openaire   +1 more source

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source

Finite Element Solutions for the Space Fractional Diffusion Equation with a Nonlinear Source Term

Abstract and Applied Analysis, 2012
We consider finite element Galerkin solutions for the space fractional diffusion equation with a nonlinear source term. Existence, stability, and order of convergence of approximate solutions for the backward Euler fully discrete scheme have been ...
Y. J. Choi, S. K. Chung
doaj   +1 more source