Results 41 to 50 of about 25,258 (265)

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Grey Wolf and Weighted Whale Algorithm Optimized IT2 Fuzzy Sliding Mode Backstepping Control with Fractional-Order Command Filter for a Nonlinear Dynamic System

Applied Sciences, 2021
In this study, a fractional-order sliding mode backstepping control method was proposed, which involved the use of a fractional-order command filter, an interval type-2 fuzzy logic system approximation method, and a grey wolf and weighted whale ...
Seongik Han
doaj   +1 more source

Spatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers

Molecular Oncology, EarlyView.
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur, Joel Rodrigues Vitória, Manuel Saiselet, Ligia Craciun, Denis Larsimont, Anne Lefort, Frédérick Libert, Carine Maenhaut, Sabine Costagliola, Maxime Tarabichi, Mirian Romitti, Vincent Detours   +11 more
wiley   +1 more source

A ℘-order R-L high-pass filter modeled by local fractional derivative

Alexandria Engineering Journal, 2020
As an important electronic device, filter is applied to all kinds of electronic products. In this paper, a new ℘-order R-L High-pass filter (HPF) modeled by the local fractional derivative (LFD) is proposed for the first time.
Kang-jia Wang, Cui-ling Li
doaj   +1 more source

Electronically Reconfigurable and Tunable Fractional-Order Filter Using Resonator Concept and Feedforward Path for Low-Frequency Tone Signalization

IEEE Access, 2021
A novel electronically reconfigurable fractional-order filter allowing independent electronic frequency tuning and switchless change of the transfer response by a single parameter between standard band-pass, inverting all-pass response and special type ...
Ondrej Domansky, Roman Sotner, Lukas Langhammer, Ladislav Polak   +3 more
doaj   +1 more source

Intrapatient tumour heterogeneity and clonal evolution in an autopsy study of metastatic salivary gland cancer

Molecular Oncology, EarlyView.
Tumour heterogeneity and clonal evolution of metastatic salivary gland cancer were evaluated in two patients with adenoid carcinoma and one patient with myoepithelial carcinoma. Radiology‐guided autopsy enabled multi‐region sampling (total samples n = 149), followed by whole‐genome sequencing and phylogenetic reconstruction (17 tumour samples, 4–7 per ...
Gerben Lassche, Niels J. van Ruitenbeek, Charlotte Adang, Luke O'Gorman, Pui Yuen Lee, Willemijn M. Klein, Adriana C. H. van Engen‐van Grunsven, Jack A. Schalken, Sander Bervoets, Gerald W. Verhaegh, Carla M. L. van Herpen   +10 more
wiley   +1 more source

New Tilt Fractional-Order Integral Derivative with Fractional Filter (TFOIDFF) Controller with Artificial Hummingbird Optimizer for LFC in Renewable Energy Power Grids

Mathematics, 2022
Recent advancements in renewable generation resources and their vast implementation in power sectors have posed serious challenges regarding their operation, protection, and control.
Emad A. Mohamed, Mokhtar Aly, Masayuki Watanabe   +2 more
doaj   +1 more source

Automated FRAP microscopy for high‐throughput analysis of protein dynamics in chromatin organization and transcription

FEBS Open Bio, EarlyView.
RoboMic is an automated confocal microscopy pipeline for high‐throughput functional imaging in living cells. Demonstrated with fluorescence recovery after photobleaching (FRAP), it integrates AI‐driven nuclear segmentation, ROI selection, bleaching, and analysis.
Selçuk Yavuz, Bart Geverts, Johan A. Slotman, Andrea Sacchetti, Stefan Prekovic, Martin E. van Royen, Adriaan B. Houtsmuller   +6 more
wiley   +1 more source

Novel realization of GIC based wave digital filters using Al-Alaoui transform

Alexandria Engineering Journal, 2018
By using the concepts of wave characterization, Al-Alaoui transform and generalized immittance converter (GIC), a new digital GIC structure is proposed which is capable of realizing all the standard second-order digital filter sections.
Richa Barsainya, Tarun Kumar Rawat
doaj   +1 more source

A light‐triggered Time‐Resolved X‐ray Solution Scattering (TR‐XSS) workflow with application to protein conformational dynamics

FEBS Open Bio, EarlyView.
Time‐resolved X‐ray solution scattering captures how proteins change shape in real time under near‐native conditions. This article presents a practical workflow for light‐triggered TR‐XSS experiments, from data collection to structural refinement. Using a calcium‐transporting membrane protein as an example, the approach can be broadly applied to study ...
Fatemeh Sabzian‐Molaei, Fredrik Orädd, Konstantinos Magkakis, Magnus Andersson   +3 more
wiley   +1 more source