Results 51 to 60 of about 24,882 (266)

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

Molecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson, Lyanne Delgado‐Coka, Natalia Marchenko, Luisa F. Escobar‐Hoyos, Kenneth R. Shroyer, Alisa Yurovsky, Trey Ideker, Gábor Balázsi, Thomas MacCarthy, Scott Powers   +9 more
wiley   +1 more source

A ℘-order R-L high-pass filter modeled by local fractional derivative

Alexandria Engineering Journal, 2020
As an important electronic device, filter is applied to all kinds of electronic products. In this paper, a new ℘-order R-L High-pass filter (HPF) modeled by the local fractional derivative (LFD) is proposed for the first time.
Kang-jia Wang, Cui-ling Li
doaj   +1 more source

Electronically Reconfigurable and Tunable Fractional-Order Filter Using Resonator Concept and Feedforward Path for Low-Frequency Tone Signalization

IEEE Access, 2021
A novel electronically reconfigurable fractional-order filter allowing independent electronic frequency tuning and switchless change of the transfer response by a single parameter between standard band-pass, inverting all-pass response and special type ...
Ondrej Domansky, Roman Sotner, Lukas Langhammer, Ladislav Polak   +3 more
doaj   +1 more source

Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma

Molecular Oncology, EarlyView.
The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic, Anne Nørremølle, Lilian Bomme Ousager, Lars van Brakel Andersen, Marie Louise Mølgaard Binderup, Mads Thomassen   +5 more
wiley   +1 more source

New Tilt Fractional-Order Integral Derivative with Fractional Filter (TFOIDFF) Controller with Artificial Hummingbird Optimizer for LFC in Renewable Energy Power Grids

Mathematics, 2022
Recent advancements in renewable generation resources and their vast implementation in power sectors have posed serious challenges regarding their operation, protection, and control.
Emad A. Mohamed, Mokhtar Aly, Masayuki Watanabe   +2 more
doaj   +1 more source

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

Novel realization of GIC based wave digital filters using Al-Alaoui transform

Alexandria Engineering Journal, 2018
By using the concepts of wave characterization, Al-Alaoui transform and generalized immittance converter (GIC), a new digital GIC structure is proposed which is capable of realizing all the standard second-order digital filter sections.
Richa Barsainya, Tarun Kumar Rawat
doaj   +1 more source

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source

A Current Mode Design of Fractional Order Universal Filter

Advances in Electrical and Computer Engineering, 2019
In this paper, low-voltage active elements based a general filter topology, which provides fractional order low-pass, high-pass, band-pass and band-reject filter responses at the same circuit, is introduced.
SACU, I. E., ALCI, M.
doaj   +1 more source

Automated FRAP microscopy for high‐throughput analysis of protein dynamics in chromatin organization and transcription

FEBS Open Bio, EarlyView.
RoboMic is an automated confocal microscopy pipeline for high‐throughput functional imaging in living cells. Demonstrated with fluorescence recovery after photobleaching (FRAP), it integrates AI‐driven nuclear segmentation, ROI selection, bleaching, and analysis.
Selçuk Yavuz, Bart Geverts, Johan A. Slotman, Andrea Sacchetti, Stefan Prekovic, Martin E. van Royen, Adriaan B. Houtsmuller   +6 more
wiley   +1 more source