Results 91 to 100 of about 60,684 (330)

A study on the existence results of boundary value problems of fractional relaxation integro-differential equations with impulsive and delay conditions in Banach spaces

AIMS Mathematics
The aim of this paper was to provide systematic approaches to study the existence of results for the system fractional relaxation integro-differential equations.
Saowaluck Chasreechai, Sadhasivam Poornima , Panjaiyan Karthikeyann, Kulandhaivel Karthikeyan, Anoop Kumar, Kirti Kaushik , Thanin Sitthiwirattham   +6 more
doaj   +1 more source

Circulating tumor DNA monitoring and blood tumor mutational burden in patients with metastatic solid tumors treated with atezolizumab

Molecular Oncology, EarlyView.
In patients treated with atezolizumab as a part of the MyPathway (NCT02091141) trial, pre‐treatment ctDNA tumor fraction at high levels was associated with poor outcomes (radiographic response, progression‐free survival, and overall survival) but better sensitivity for blood tumor mutational burden (bTMB).
Charles Swanton, Russell W. Madison, Candice Francheska B. Tambaoan, Funda Meric‐Bernstam, Christopher J. Sweeney, Razelle Kurzrock, Howard A. Burris III, David R. Spigel, Hanna Tukachinsky, Jason Hughes, Julia Malato, Bongin Yoo, Tania Szado, Cheryl Schwab, Lincoln W. Pasquina, Amaya Gasco, Katja Schulze, Claire F. Friedman   +17 more
wiley   +1 more source

Fractional order calculus: historical apologia, basic concepts and some applications

Revista Brasileira de Ensino de Física
Fractional order calculus (FOC) deals with integrals and derivatives of arbitrary (i.e., non-integer) order, and shares its origins with classical integral and differential calculus.
S.A. David, J.L. Linares, E.M.J.A. Pallone   +2 more
doaj   +1 more source

A survey on fractional variational calculus [PDF]

, 2019
This is a preprint of a paper whose final and definite form is in 'Handbook of Fractional Calculus with Applications. Vol 1: Basic Theory', De Gruyter.
Almeida, Ricardo, Torres, Delfim F. M.
openaire   +3 more sources

Genomics‐led approach to drug testing in models of undifferentiated pleomorphic sarcoma

Molecular Oncology, EarlyView.
GA text Genomic data from undifferentiated pleomorphic sarcoma patients and preclinical models were used to inform a targeted drug screen. Selected compounds were tested in 2D and 3D cultures of UPS cell lines. A combination of trametinib and infigratinib was synergistic in the majority of UPS cell lines tested, which was further confirmed in an ex ...
Piotr J. Manasterski, Molly R. Danks, John P. Thomson, Morwenna Muir, Martin Lee, John C. Dawson, Ana T. Amaral, Juan Diaz‐Martin, David S. Moura, Javier Martin‐Broto, Ali Alsaadi, Donald M. Salter, Ailsa J. Oswald, Graeme Grimes, Larry Hayward, Ted R. Hupp, Karen Sisley, Paul H. Huang, Neil O. Carragher, Valerie G. Brunton   +19 more
wiley   +1 more source

A nucleotide‐independent, pan‐RAS‐targeted DARPin elicits anti‐tumor activity in a multimodal manner

Molecular Oncology, EarlyView.
We report a Designed Ankyrin Repeat Protein that binds and inhibits RAS proteins, which serve as central cell signaling hubs and are essential for the progression of many cancers. Its unique feature is that it does not discriminate between different RAS isoforms or mutations and is capable of binding to RAS in both its active (GTP‐bound) and inactive ...
Jonas N. Kapp, Wouter P. R. Verdurmen, Jonas V. Schaefer, Kari Kopra, Gabriela Nagy‐Davidescu, Elodie Richard, Marie‐Julie Nokin, Patrick Ernst, Rastislav Tamaskovic, Martin Schwill, Ralph Degen, Claudia Scholl, David Santamaria, Andreas Plückthun   +13 more
wiley   +1 more source

Towards a combined fractional mechanics and quantization

, 2012
A fractional Hamiltonian formalism is introduced for the recent combined fractional calculus of variations. The Hamilton-Jacobi partial differential equation is generalized to be applicable for systems containing combined Caputo fractional derivatives ...
Malinowska, Agnieszka B., Torres, Delfim F. M.   +1 more
core   +1 more source

From Fractional Quantum Mechanics to Quantum Cosmology: An Overture

Mathematics, 2020
Fractional calculus is a couple of centuries old, but its development has been less embraced and it was only within the last century that a program of applications for physics started. Regarding quantum physics, it has been only in the previous decade or
Paulo Vargas Moniz, Shahram Jalalzadeh
doaj   +1 more source

Operators of Fractional Calculus and Their Applications [PDF]

Mathematics, 2018
n ...
openaire   +5 more sources

Tumor clusters with divergent inflammation and human retroelement expression determine the clinical outcome of patients with serous ovarian cancer

Molecular Oncology, EarlyView.
Analysis of treatment‐naïve high‐grade serous ovarian carcinoma (HGSOC) and control tissues for ERVs, LINE‐1 (L1), inflammation, and immune checkpoints identified five clusters with diverse patient recurrence‐free survivals. An inflammation score was calculated and correlated with retroelement expression, where one novel cluster (Triple‐I) with high ...
Laura Glossner, Markus Eckstein, Christoph Mark, Matthias W. Beckmann, Arndt Hartmann, Pamela L. Strissel, Reiner Strick   +6 more
wiley   +1 more source