Results 81 to 90 of about 354,882 (289)

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

Input-output linearization and fractional robust control of a non-linear system [PDF]

, 2001
This article deals with the association of a linear robust controller and an input-output linearization feedback for the control of a perturbed and non-linear system.
Oustaloup, Alain, Pommier-Budinger, Valérie, Jocelyn Sabatier, Patrick Lanusse, Lanusse, Patrick, Valerie Pommier, Sabatier, Jocelyn, Alain Oustaloup   +7 more
core   +1 more source

A comprehensive survey on recent advances in multiplicative fractional calculus and related integral inequalities

Journal of Inequalities and Applications
The present article intends to give a comprehensive survey of recent developments in the literature on multiplicative fractional integral inequalities.
Thabet Abdeljawad, Sumaiya Tasneem Zubair, Abdelghani Lakhdari, Badreddine Meftah, Aiman Mukheimer   +4 more
doaj   +1 more source

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

Necessary optimality conditions for fractional action-like problems with intrinsic and observer times [PDF]

, 2008
We prove higher-order Euler-Lagrange and DuBois-Reymond stationary conditions to fractional action-like variational problems.
Frederico, G.S.F., Torres, D.F.M.
core   +1 more source

Ćirić-type generalized F-contractions with integral inclusion in super metric spaces

Results in Control and Optimization
This study aims to explore Ćirić-type generalized F-contractions, almost F-contractions, and the combination of these contractions in the framework of super metric spaces.
Kamaleldin Abodayeh, Syed Khayyam Shah, Muhammad Sarwar, Chanon Promsakon, Thanin Sitthiwirattham   +4 more
doaj   +1 more source

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

Science metrics on fractional calculus development since 1966

, 2013
During the last fifty years the area of Fractional Calculus verified a considerable progress.
Galhano, Alexandra, Trujillo, Juan J., Machado, J. A. Tenreiro   +2 more
core   +1 more source

Analysis on nonlinear differential equation with a deviating argument via Faedo–Galerkin method

Results in Applied Mathematics
This article focuses on the impulsive fractional differential equation (FDE) of Sobolev type with a nonlocal condition. Existence and uniqueness of the approximations are determined via analytic semigroup and fixed point method.
M. Manjula, E. Thilakraj, P. Sawangtong, K. Kaliraj   +3 more
doaj   +1 more source

Covariance in fractional calculus

International Journal of Modern Physics A
Based on the requirement of covariance, we propose a new approach for generalizing fractional calculus in multi-dimensional space. As a first application, we calculate an approximation for the ground state energy of the fractional two-dimensional harmonic oscillator using the Ritz variational principle.
openaire   +2 more sources