Results 61 to 70 of about 372,103 (253)

Fractional variational problems with the Riesz-Caputo derivative [PDF]

, 2012
In this paper we investigate optimality conditions for fractional variational problems, with a Lagrangian depending on the Riesz-Caputo derivative. First we prove a generalized Euler-Lagrange equation for the case when the interval of integration of the ...
Almeida, R., Ricardo Almeida
core   +1 more source

How structural disorder and polyelectrolyte properties of prothymosin α enable its large interactome

FEBS Letters, EarlyView.
In this review, complexes of the fully disordered and highly negatively charged prothymosin α are collected, described, and discussed. Linked to its poly‐electrostatic character, prothymosin α engages a large interactome through multiple different binding modes ranging from fully disordered complexes to short linear motif (SLiM)‐driven interactions ...
Ketty C. Tamburrini, Freia S. Buus, Benjamin Schuler, Birthe B. Kragelund   +3 more
wiley   +1 more source

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

A comprehensive survey on recent advances in multiplicative fractional calculus and related integral inequalities

Journal of Inequalities and Applications
The present article intends to give a comprehensive survey of recent developments in the literature on multiplicative fractional integral inequalities.
Thabet Abdeljawad, Sumaiya Tasneem Zubair, Abdelghani Lakhdari, Badreddine Meftah, Aiman Mukheimer   +4 more
doaj   +1 more source

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

Ćirić-type generalized F-contractions with integral inclusion in super metric spaces

Results in Control and Optimization
This study aims to explore Ćirić-type generalized F-contractions, almost F-contractions, and the combination of these contractions in the framework of super metric spaces.
Kamaleldin Abodayeh, Syed Khayyam Shah, Muhammad Sarwar, Chanon Promsakon, Thanin Sitthiwirattham   +4 more
doaj   +1 more source

A fractional calculus perspective in the evolutionary design of combinational circuits

, 2007
This paper analyses the performance of a genetic algorithm (GA) in the synthesis of digital circuits using two novel approaches. The first concept consists in improving the static fitness function by including a discontinuity evaluation.
J. Boaventura Cunha, Cunha, J. Boaventura, Cecília Reis, Reis, Cecília, J. A. Tenreiro Machado, Machado, J. A. Tenreiro   +5 more
core   +1 more source

Methods for Solving Some Fractional Integral

, 2023
: In this paper, based on Jumarie’s modified Riemann-Liouville (R-L) fractional calculus, we evaluate some fractional integral. The main methods we used are fractional L’Hospital’s rule, integration by parts for fractional calculus, and a new ...
Chii-Huei Yu
core   +1 more source

Spatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers

Molecular Oncology, EarlyView.
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur, Joel Rodrigues Vitória, Manuel Saiselet, Ligia Craciun, Denis Larsimont, Anne Lefort, Frédérick Libert, Carine Maenhaut, Sabine Costagliola, Maxime Tarabichi, Mirian Romitti, Vincent Detours   +11 more
wiley   +1 more source

Analysis on nonlinear differential equation with a deviating argument via Faedo–Galerkin method

Results in Applied Mathematics
This article focuses on the impulsive fractional differential equation (FDE) of Sobolev type with a nonlocal condition. Existence and uniqueness of the approximations are determined via analytic semigroup and fixed point method.
M. Manjula, E. Thilakraj, P. Sawangtong, K. Kaliraj   +3 more
doaj   +1 more source