Results 61 to 70 of about 354,882 (289)

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source

Multivariable Fractional-Order Controller Design for a Nonlinear Dual-Tank Device

Fractal and Fractional, 2023
Fractional calculus is defined by expanded integer order integration and differentiation. In this paper, multiple mathematical models of a nonlinear dual-tank device are precisely formulated by fractional calculus.
Ryota Kochi, Mingcong Deng
doaj   +1 more source

Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions

FEBS Letters, EarlyView.
The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang, Hyo Been Jin, Chang Min Kim, So Yeon Lee, Hyun Ho Park   +4 more
wiley   +1 more source

Fractional robust control with iso-damping property [PDF]

, 2008
This article deals with the problem of the reduction of structural vibrations with isodamping property. The proposed methodology is based on: - a contour defined in the Nichols plane and significant of the damping ratio of the closed-loop response - a ...
Janat, Yaman, Oustaloup, Alain, Pommier-Budinger, Valérie, A. Oustaloup, V. Pommier-Budinger, D. Nelson-Gruel, Lanusse, Patrick, Nelson-Gruel, Dominique, Y. Janat, P. Lanusse   +9 more
core   +1 more source

Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network

FEBS Letters, EarlyView.
Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley   +1 more source

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

FEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri, Ayaka Nagasato‐Ichikawa, Keita Iida, Shuhei Kimura, Akira Imamoto, Mariko Okada   +5 more
wiley   +1 more source

Fractional order calculus: historical apologia, basic concepts and some applications

Revista Brasileira de Ensino de Física
Fractional order calculus (FOC) deals with integrals and derivatives of arbitrary (i.e., non-integer) order, and shares its origins with classical integral and differential calculus.
S.A. David, J.L. Linares, E.M.J.A. Pallone   +2 more
doaj   +1 more source

New definitions of fractional derivatives and integrals for complex analytic functions

Arab Journal of Basic and Applied Sciences, 2023
In this paper, we introduce a ground-breaking approach to defining fractional calculus for a selected class of analytic functions. Our new definitions, based on a novel and intuitive understanding of fractional derivatives and integrals, offer improved ...
Mohammad Abu-Ghuwaleh, Rania Saadeh
doaj   +1 more source

Emerging experimental and computational methods for studying redox‐regulated structural transitions

FEBS Letters, EarlyView.
Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass, Dana Reichmann, Gábor Erdős   +2 more
wiley   +1 more source

Using the fractional order calculus in the combination of the MIT and Lyapunov stability method

, 2020
The main idea of the current paper consists in introducing the fractional order calculus in a control system. To control the system, an adaptive control technique with reference model is used. The fractional order models for the plant and reference model
Coman, Simona, Simona Coman, Cristian Boldisor, Boldisor, Cristian   +3 more
core   +1 more source