Results 101 to 110 of about 492,476 (332)
Molecular Oncology, EarlyView.Clinical trials on PARP inhibitors in urothelial carcinoma (UC) showed limited efficacy and a lack of predictive biomarkers. We propose SLFN5, SLFN11, and OAS1 as UC‐specific response predictors. We suggest Talazoparib as the better PARP inhibitor for UC than Olaparib.
Jutta Schmitz +15 more
wiley +1 more source
Two-scale mathematics and fractional calculus for thermodynamics
Thermal Science, 2019 A three dimensional problem can be approximated by either a two-dimensional or one-dimensional case, but some information will be lost. To reveal the lost information due to the lower dimensional approach, two-scale mathematics is needed.
Ji-Huan He, Feiyu Ji
semanticscholar +1 more source
Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway
Molecular Oncology, EarlyView.Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed +10 more
wiley +1 more source
A review on epidemic models in sight of fractional calculus
Alexandria Engineering Journal, 2023 K. Nisar +3 more
semanticscholar +1 more source
On History of Mathematical Economics: Application of Fractional Calculus
Mathematics, 2019 Modern economics was born in the Marginal revolution and the Keynesian revolution. These revolutions led to the emergence of fundamental concepts and methods in economic theory, which allow the use of differential and integral calculus to describe ...
V. E. Tarasov
semanticscholar +1 more source
Molecular Oncology, EarlyView.Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra +10 more
wiley +1 more source
Abstract and Applied Analysis, 2013 The traditional integer-order partial differential equation-based image denoising approaches often blur the edge and complex texture detail; thus, their denoising effects for texture image are not very good.
Yi-Fei Pu +4 more
doaj +1 more source
Effect of chemotherapy on passenger mutations in metastatic colorectal cancer
Molecular Oncology, EarlyView.Changes in passenger mutation load and predicted immunotherapy response after chemotherapy treatment. Tumor cells rich with passenger mutations have increased sensitivity to chemotherapy. Correlation of passenger mutations with neoantigen load suggests highly mutated clones promote a more effective response to immunotherapy, and therefore, first‐line ...
Marium T. Siddiqui +6 more
wiley +1 more source
On fractional Bullen-type inequalities with applications
AIMS MathematicsIntegral inequalities in mathematical interpretations are a substantial and ongoing body of research. Because fractional calculus techniques are widely used in science, a lot of research has recently been done on them.
Sobia Rafeeq, Sabir Hussain, Jongsuk Ro
doaj +1 more source
Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells
Molecular Oncology, EarlyView.Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son +13 more
wiley +1 more source