Results 51 to 60 of about 11,696 (294)

A Cre‐dependent lentiviral vector for neuron subtype‐specific expression of large proteins

FEBS Letters, EarlyView.
We designed a versatile and modular lentivector comprising a Cre‐dependent switch and self‐cleaving 2A peptide and tested it for co‐expression of GFP and a 2.8 kb gene of interest (GOI) in mouse cortical parvalbumin (PV+) interneurons and midbrain dopamine (TH+) neurons.
Weixuan Xue, Sandrine Picaud, Régine Hepp, Stéphanie Pons, Uwe Maskos, Bertrand Lambolez, Ludovic Tricoire   +6 more
wiley   +1 more source

On nonlinear fractional Hahn integrodifference equations via nonlocal fractional Hahn integral boundary conditions

AIMS Mathematics
All authors Fractional Hahn differences and fractional Hahn integrals have various applications in fields where discrete fractional calculus plays a significant role, such as in discrete biological modeling and signal processing to handle systems with ...
Nichaphat Patanarapeelert, Jiraporn Reunsumrit, Thanin Sitthiwirattham   +2 more
doaj   +1 more source

Targeting EZH2 reverses thyroid cell dedifferentiation and enhances iodide uptake in anaplastic thyroid cancer

FEBS Letters, EarlyView.
Anaplastic thyroid cancer (ATC) lacks iodide uptake ability due to MAPK activation increasing the expression of the histone methyltransferase EZH2, which represses thyroid differentiation genes (TDGs) such as the sodium iodide symporter (NIS). Dual inhibition of MAPK (U0126) and EZH2 (EPZ6438/Tazemetostat) reverses this mechanism, thus restoring TDG ...
Diego Claro de Mello, Marcella Maringolo Cristovão, Guilherme Henrique, Vinicius Gonçalves Rodrigues, Caroline Serrano‐Nascimento, Edna Teruko Kimura, Cesar Seigi Fuziwara   +6 more
wiley   +1 more source

Sturm-Liouville problem in multiplicative fractional calculus

AIMS Mathematics
Multiplicative calculus, or geometric calculus, is an alternative to classical calculus that relies on division and multiplication as opposed to addition and subtraction, which are the basic operations of classical calculus.
Tuba Gulsen, Sertac Goktas, Thabet Abdeljawad , Yusuf Gurefe   +3 more
doaj   +1 more source

Abelian Groups of Fractional Operators

Computer Sciences & Mathematics Forum, 2022
Taking into count the large number of fractional operators that have been generated over the years, and considering that their number is unlikely to stop increasing at the time of writing this paper due to the recent boom of fractional calculus ...
Anthony Torres-Hernandez, Fernando Brambila-Paz, Rafael Ramirez-Melendez   +2 more
doaj   +1 more source

The Caenorhabditis elegans DPF‐3 and human DPP4 have tripeptidyl peptidase activity

FEBS Letters, EarlyView.
The dipeptidyl peptidase IV (DPPIV) family comprises serine proteases classically defined by their ability to remove dipeptides from the N‐termini of substrates, a feature that gave the family its name. Here, we report the discovery of a previously unrecognized tripeptidyl peptidase activity in DPPIV family members from two different species.
Aditya Trivedi, Rajani Kanth Gudipati
wiley   +1 more source

Fractional Solutions of Bessel Equation with -Method

The Scientific World Journal, 2013
This paper deals with the design fractional solution of Bessel equation. We obtain explicit solutions of the equation with the help of fractional calculus techniques.
Erdal Bas, Resat Yilmazer, Etibar Panakhov   +2 more
doaj   +1 more source

Modified Mittag-Leffler Functions with Applications in Complex Formulae for Fractional Calculus

Fractal and Fractional, 2020
Mittag-Leffler functions and their variations are a popular topic of study at the present time, mostly due to their applications in fractional calculus and fractional differential equations.
Arran Fernandez, Iftikhar Husain
doaj   +1 more source

Real‐time assay of ribonucleotide reductase activity with a fluorescent RNA aptamer

FEBS Letters, EarlyView.
Ribonucleotide reductases (RNR) synthesize DNA building blocks de novo, making them crucial in DNA replication and drug targeting. FLARE introduces the first single‐tube real‐time coupled RNR assay, which enables isothermal tracking of RNR activity at nanomolar enzyme levels and allows the reconstruction of allosteric regulatory patterns and rapid ...
Jacopo De Capitani, Noemi E. Nwosu, Viktoria Gocke, Müge Kasanmascheff, Hannes Mutschler   +4 more
wiley   +1 more source

Disordered but rhythmic—the role of intrinsic protein disorder in eukaryotic circadian timing

FEBS Letters, EarlyView.
Unstructured domains known as intrinsically disordered regions (IDRs) are present in nearly every part of the eukaryotic core circadian oscillator. IDRs enable many diverse inter‐ and intramolecular interactions that support clock function. IDR conformations are highly tunable by post‐translational modifications and environmental conditions, which ...
Emery T. Usher, Jacqueline F. Pelham
wiley   +1 more source