Results 111 to 120 of about 166,029,081 (260)

Transcripts enriched in codons that trigger P‐site tRNA‐mediated mRNA decay possess stable mRNA

FEBS Open Bio, EarlyView.
PTMD codons were first described by Mendel et al. as mediators of an mRNA decay pathway dependent on the human protein CNOT3, homologous to yeast Not5. Our findings confirm that PTMD codons destabilize transcripts; however, unlike in yeast, the human pathway specifically targets and slightly destabilizes primarily stable mRNAs.
Rodolfo Lopes Carneiro, Fernando Lucas Palhano   +1 more
wiley   +1 more source

Effects of IGFBP4 deficiency on human preadipocyte proliferation and differentiation through the IGF1R/AKT pathway

FEBS Open Bio, EarlyView.
IGFBP4 knockdown (KD) impairs preadipocyte proliferation and is associated with IGF1R protein downregulation and attenuated AKT phosphorylation. The mechanisms by which IGFBP4 KD influences the IGF1R/AKT signaling pathway involve newly synthesized proteins and lysosomal degradation pathways. Created in BioRender.
Yujia Guo, Sandy Richter, Christoph Bach, Wieland Kiess, Anna Kirstein, Diana Le Duc, Antje Garten   +6 more
wiley   +1 more source

Option Pricing in a Fractional Brownian Motion Environment [PDF]

The purpose of this paper is to obtain a fractional Black-Scholes formula for the price of an option for every t in [0,T], a fractional Black-Scholes equation and a risk-neutral valuation theorem if the underlying is driven by a fractional Brownian ...
Cipian Necula
core  

Performances improvement of DC Motor using a Fractional Order Adaptive PID Controller optimized by Genetic Algorithm

Science, Engineering and Technology
In the past 20 years, scientists and engineers have rediscovered fractional calculus and have begun using it in more and more domains, most notably control theory.
Abdelouaheb Boukhalfa, Yassine Bensafia, Khatir Khettab   +2 more
doaj   +1 more source

Treatment with KCL‐286, a first‐in‐class retinoic acid receptor‐β (RARβ) agonist, ameliorates neuronal DNA damage and inflammation in a mouse model of Alzheimer's disease

FEBS Open Bio, EarlyView.
Repair of neuronal DNA damage in Alzheimer's disease by KCL‐286. (A) Amyloid‐β oligomers and plaques impair neuronal DNA repair pathways, leading to DNA double‐strand breaks and glial activation. (B) KCL‐286 activates RARβ/RXR signalling via retinoic acid response elements (RAREs), associated with increased BRCA1 expression, enhanced DNA repair and ...
Natasha Hill, Hassan Yousef Othman AlMuallim, Elouisa Maddock, Carl Hobbs, Earl Clarke, Maria B. Goncalves, Jonathan P. T. Corcoran   +6 more
wiley   +1 more source

A Framework for Derivative Pricing in the Fractional Black-Scholes Market [PDF]

The aim of this paper is to develop a framework for evaluating derivatives if the underlying of the derivative contract is supposed to be driven by a fractional Brownian motion with Hurst parameter greater than 0.5.
Ciprian Necula
core  

Notions of affinity in calculus of variations with differential forms [PDF]

Ext-int. one affine functions are functions affine in the direction of one-divisible exterior forms with respect to the exterior product in one variable and with respect to the interior product in the other.
Bandyopadhyay, Saugata, Sil, Swarnendu
core   +1 more source

Fractal–Fractional Synergy in Geo-Energy Systems: A Multiscale Framework for Stress Field Characterization and Fracture Network Evolution Modeling

Fractal and Fractional
This research introduces an innovative fractal–fractional synergy framework for multiscale analysis of stress field dynamics in geo-energy systems.
Qiqiang Ren, Tianhao Gao, Rongtao Jiang, Jin Wang, Mengping Li, Jianwei Feng, He Du   +6 more
doaj   +1 more source

Importin 7 mediates the nuclear import of HIV‐1 integrase via a specific interacting interface

FEBS Open Bio, EarlyView.
HIV‐1 integrase enables viral DNA integration into the host genome. By binding to the core domain of the host protein Importin 7 via its C‐terminal domain, the integrase is transported across the nuclear membrane into the nucleus, where integration of the viral genome into host DNA takes place. This translocation is a critical step for subsequent viral
Juana Bana, Avigail Yariv, Tal Oppenheim, Hadar Amartely, Dana Reichmann, Oded Livnah   +5 more
wiley   +1 more source

Five Years of Continuous-time Random Walks in Econophysics [PDF]

This paper is a short review on the application of continuos-time random walks to Econophysics in the last five years.Duration; Continuous-time random walk; Fractional calculus; Statistical ...
Enrico Scalas
core