Results 131 to 140 of about 20,179 (274)

The Duality Theory of Fractional Calculus and a New Fractional Calculus of Variations Involving Left Operators Only

Mediterranean Journal of Mathematics
AbstractThrough duality, it is possible to transform left fractional operators into right fractional operators and vice versa. In contrast to existing literature, we establish integration by parts formulas that exclusively involve either left or right operators.
openaire   +4 more sources

Development of human monoclonal antibodies against TARM1 by yeast display

FEBS Open Bio, EarlyView.
Human monoclonal antibodies against TARM1 are generated by yeast display‐guided selection. These antibodies bind to soluble and cell‐surface forms of TARM1. Also, these antibodies exhibit agonistic activity in the NFAT‐GFP reporter assay, indicating that TARM1 signaling can be functionally modulated by antibodies and suggesting TARM1 as a potential ...
Rikio Yabe, Mayumi Saeki, Masaaki Hashiguchi, Sayaka Ono, Kazuhisa Aoki, Hidetaka Tanno   +5 more
wiley   +1 more source

Fractal–Fractional Synergy in Geo-Energy Systems: A Multiscale Framework for Stress Field Characterization and Fracture Network Evolution Modeling

Fractal and Fractional
This research introduces an innovative fractal–fractional synergy framework for multiscale analysis of stress field dynamics in geo-energy systems.
Qiqiang Ren, Tianhao Gao, Rongtao Jiang, Jin Wang, Mengping Li, Jianwei Feng, He Du   +6 more
doaj   +1 more source

Screening and epitope characterization of Nidogen‐2‐specific nanobodies

FEBS Open Bio, EarlyView.
Camel immunization and phage display were employed to generate high‐affinity VHH nanobodies against Nidogen‐2. After library construction, biopanning, ELISA screening, sequencing, and recombinant expression, selected nanobodies were purified and characterized, leading to the preliminary exploration of a nanobody‐based sandwich ELISA for specific ...
Jianchuan Wen, Qianqian Cui, Zhongyun Lan, Yingjun Wang, Shuaiying Zhao, Wenxuan Feng, Yunfeng Liu, Qiting Huang, Dongna Zhang, Jianfeng Xu   +9 more
wiley   +1 more source

A hybrid technique for solving fractional delay variational problems by the shifted Legendre polynomials

Partial Differential Equations in Applied Mathematics
This study presents a practical method for solving fractional order delay variational problems. The fractional derivative is given in the Caputo sense.
Hasnaa F. Mohammed, Osama H. Mohammed
doaj   +1 more source

Proteasomal degradation of intracellularly expressed Amblyomin‐X limits suicide gene therapy potential in melanoma cells

FEBS Open Bio, EarlyView.
This study explores the feasibility of expressing the antitumoral protein Amblyomin‐X through a suicide gene therapy approach and investigates its intracellular fate after gene delivery. Although the gene is efficiently expressed, melanoma cells rapidly degrade the Amblyomin‐X protein via proteasome activity.
Victor Dal Posolo Cinel, Carlos DeOcesano Pereira, Aline Ramos Maia Lobba, Melissa Regina Fessel, Ana Marisa Chudzinski‐Tavassi   +4 more
wiley   +1 more source

Rapid screening of staphylokinase protein variants using an unpurified cell‐free expression system

FEBS Open Bio, EarlyView.
An unpurified cell‐free protein synthesis (CFPS) platform enables rapid functional screening of staphylokinase variants. Direct plasminogen‐activation assays performed in microplate format provide real‐time activity readouts, allowing rapid identification and ranking of variants with improved or reduced fibrinolytic activity without protein ...
Maria Tomková, Veronika Hovanová, Jiri Damborsky, Erik Sedlák   +3 more
wiley   +1 more source

A discrete time method to the first variation of fractional order variational functionals

Open Physics, 2013
Pooseh Shakoor, Almeida Ricardo, Torres Delfim   +2 more
doaj   +1 more source

Fractional-order super-twisting sliding mode active disturbance rejection control for electro-hydraulic position servo systems

Nonlinear Engineering
To address the inherent nonlinearity, time-varying dynamics, and disturbance susceptibility of electro-hydraulic position servo systems in high-precision applications like aerospace actuators, this article proposes a fractional-order super-twisting ...
Yuesong Li, Huixuan Long, Long Meng, Nao Shi, Jiali Xu, Zhiguang Pan   +5 more
doaj   +1 more source

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source