Results 51 to 60 of about 187,262 (303)

The immunological interface: dendritic cells as key regulators in metabolic dysfunction‐associated steatotic liver disease

open access: yesFEBS Letters, EarlyView.
Metabolic dysfunction‐associated steatotic liver disease (MASLD) affects nearly one‐third of the global population and poses a significant risk of progression to cirrhosis or liver cancer. Here, we discuss the roles of hepatic dendritic cell subtypes in MASLD, highlighting their distinct contributions to disease initiation and progression, and their ...
Camilla Klaimi   +3 more
wiley   +1 more source

A New Truncated M-Fractional Derivative Type Unifying Some Fractional Derivative Types with Classical Properties

open access: yesInternational Journal of Analysis and Applications, 2018
We introduce a truncated $M$-fractional derivative type for $\alpha$-differentiable functions that generalizes four other fractional derivatives types recently introduced by Khalil et al., Katugampola and Sousa et al., the so-called conformable ...
J. Vanterler da C. Sousa   +1 more
doaj   +2 more sources

Fractional Cauchy problems on bounded domains

open access: yes, 2008
Fractional Cauchy problems replace the usual first-order time derivative by a fractional derivative. This paper develops classical solutions and stochastic analogues for fractional Cauchy problems in a bounded domain $D\subset\mathbb{R}^d$ with Dirichlet
Meerschaert, Mark M.   +2 more
core   +4 more sources

Making tau amyloid models in vitro: a crucial and underestimated challenge

open access: yesFEBS Letters, EarlyView.
This review highlights the challenges of producing in vitro amyloid assemblies of the tau protein. We review how accurately the existing protocols mimic tau deposits found in the brain of patients affected with tauopathies. We discuss the important properties that should be considered when forming amyloids and the benchmarks that should be used to ...
Julien Broc, Clara Piersson, Yann Fichou
wiley   +1 more source

A Simple and Effective Second-Order Numerical Algorithm for Tempered Fractional Differential Equation With Time Caputo-Tempered Fractional Derivative

open access: yesAdvances in Mathematical Physics
This paper presents an efficient numerical scheme for the space–time tempered fractional convection–diffusion equation, where the time derivative is the Caputo-tempered fractional derivative and the space derivatives are the normalized left and right ...
Dechao Gao   +3 more
doaj   +1 more source

Unraveling Mycobacterium tuberculosis acid resistance and pH homeostasis mechanisms

open access: yesFEBS Letters, EarlyView.
Mycobacterium tuberculosis exhibits a remarkable resilience to acid stress. In this Review, we discuss some of the molecular mechanisms and metabolic pathways used by the tubercle bacilli to adapt and resist host‐mediated acid stress. Mycobacterium tuberculosis (Mtb) is a successful pathogen that has developed a variety of strategies to survive and ...
Janïs Laudouze   +3 more
wiley   +1 more source

The solutions of time and space conformable fractional heat equations with conformable Fourier transform

open access: yesActa Universitatis Sapientiae: Mathematica, 2015
In this paper our aim is to find the solutions of time and space fractional heat differential equations by using new definition of fractional derivative called conformable fractional derivative.
Çenesiz Yücel, Kurt Ali
doaj   +1 more source

On Hilfer generalized proportional fractional derivative

open access: yesAdvances in Difference Equations, 2020
Motivated by the Hilfer and the Hilfer–Katugampola fractional derivative, we introduce in this paper a new Hilfer generalized proportional fractional derivative, which unifies the Riemann–Liouville and Caputo generalized proportional fractional ...
Idris Ahmed   +4 more
doaj   +1 more source

Refining the NaV1.7 pharmacophore of a class of venom‐derived peptide inhibitors via a combination of in silico screening and rational engineering

open access: yesFEBS Letters, EarlyView.
Venom peptides have shown promise in treating pain. Our study uses computer screening to identify a peptide that targets a sodium channel (NaV1.7) linked to chronic pain. We produced the peptide in the laboratory and refined its design, advancing the search for innovative pain therapies.
Gagan Sharma   +8 more
wiley   +1 more source

On Generalized Composite Fractional Derivative

open access: yesWalailak Journal of Science and Technology, 2014
In the present paper, we define a generalized composite fractional derivative and obtain results, which include the image of power function, Laplace transform and composition of Riemann-Liouville fractional integral with the generalized composite ...
Mridula GARG   +3 more
doaj   +1 more source

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