Results 151 to 160 of about 40,668 (308)

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

open access: yesMolecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan   +16 more
wiley   +1 more source

A new approach to compute Riemann–Liouville and Caputo fractional derivatives for a product of two functions

open access: yesInternational Journal of Mathematics for Industry
This paper aims to contribute to and broaden the current understanding of fractional calculus and its uses in science. In general, determining the fractional derivative of a product of two functions is an obstacle.
Rami AlAhmad   +2 more
doaj   +1 more source

FRACTIONAL-ORDER VARIATIONAL DERIVATIVE

open access: yesInternational Journal of Apllied Mathematics, 2016
We consider some possible approaches to the fractional-order generalization of definition of variation (functional) derivative. Some problems of formulation of a fractional-order variational derivative are discussed. To give a consistent definition of the fractional-order variations, we use a fractional generalization of Gateaux differential.
openaire   +2 more sources

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

open access: yesMolecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu   +10 more
wiley   +1 more source

A Novel Fractional Iterative Technique of Order (2λ+1) With Applications to Engineering

open access: yesComputational and Mathematical Methods
Fractional derivatives are widely used to model complex phenomena where classical derivatives fail to provide accurate solutions. As a result, iterative methods involving fractional derivatives have become highly significant for addressing such ...
Saima Akram   +4 more
doaj   +1 more source

Interaction of HS1BP3 with cortactin modulates TKS5 localisation, cell secretion and cancer malignancy

open access: yesMolecular Oncology, EarlyView.
Here, we demonstrate that HS1BP3 interacts with Cortactin through a proline‐rich region (PRR3.1) and show that this interaction, and HS1BP3 itself, promote cancer cell proliferation and invasion. Inhibition of this interaction leads to build‐up of TKS5 in multivesicular endosomes and altered secretion of CD63 and CD9, providing an explanation for the ...
Arja Arnesen Løchen   +9 more
wiley   +1 more source

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