Results 81 to 90 of about 3,363,294 (297)

Modelling stem cell differentiation related processes—A practical overview for biologists

FEBS Letters, EarlyView.
Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar, Xinqi Yan, Lucas F. Jansen Klomp, Stefano Schivo, Janine N. Post   +4 more
wiley   +1 more source

Stability of nonlinear $h$-difference systems with $n$ fractional orders [PDF]

, 2015
summary:In the paper we study the subject of stability of systems with $h$-differences of Caputo-, Riemann-Liouville- and Grünwald-Letnikov-type with $n$ fractional orders.
Girejko, Ewa, Wyrwas, Małgorzata, Pawluszewicz, Ewa   +2 more
core   +1 more source

Existence Results for Fractional Hahn Difference and Fractional Hahn Integral Boundary Value Problems

Discrete Dynamics in Nature and Society, 2017
The existence and uniqueness results of two fractional Hahn difference boundary value problems are studied. The first problem is a Riemann-Liouville fractional Hahn difference boundary value problem for fractional Hahn integrodifference equations.
Nichaphat Patanarapeelert, Thanin Sitthiwirattham   +1 more
doaj   +1 more source

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

Oscillation theorems for nonlinear fractional difference equations

Boundary Value Problems, 2018
In this study, we discuss some theorems related to the oscillatory behavior of nonlinear fractional difference equations equipped with well-known fractional Riemann–Liouville difference operator.
Hakan Adiguzel
doaj   +1 more source

Sources of Individual Differences in Children's Understanding of Fractions [PDF]

Child Development, 2014
Abstract Longitudinal associations of domain-general and numerical competencies with individual differences in children's understanding of fractions were investigated. Children (n = 163) were assessed at 6 years of age on domain-general (nonverbal reasoning, language, attentive behavior, executive control, visual-spatial memory) and ...
Rose K, Vukovic, Lynn S, Fuchs, David C, Geary, Nancy C, Jordan, Russell, Gersten, Robert S, Siegler   +5 more
openaire   +2 more sources

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Identification of a Shiga toxin A‐derived peptide internalized into Gb3 receptor‐bearing cells via interaction with the Shiga toxin B subunit

FEBS Letters, EarlyView.
The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi, João C. Encarnação, Valeria Napolitano, Grzegorz Dubin, Grzegorz Popowicz, Karl Andersson, U. Helena Danielson   +6 more
wiley   +1 more source

Oscillation results for certain fractional difference equations

Journal of Hebei University of Science and Technology, 2017
Fractional calculus is a theory that studies the properties and application of arbitrary order differentiation and integration. It can describe the physical properties of some systems more accurately, and better adapt to changes in the system, playing an
Zhiyun WANG, Shujuan LIU, Qiaoluan LI
doaj   +1 more source

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source