Results 81 to 90 of about 713,574 (373)

Substrate specificity of Burkholderia pseudomallei multidrug transporters is influenced by the hydrophilic patch in the substrate‐binding pocket

FEBS Letters, EarlyView.
Multidrug transporters BpeB and BpeF from the Gram‐negative pathogen Burkholderia pseudomallei have a hydrophilic patch in their substrate‐binding pocket. Drug susceptibility tests and growth curve analyses using an Escherichia coli recombinant expression system revealed that the hydrophilic patches of BpeB and BpeF are involved in the substrate ...
Ui Okada, Satoshi Murakami
wiley   +1 more source

On Solutions of Fractional order Telegraph Partial Differential Equation by Crank-Nicholson Finite Difference Method

Applied Mathematics and Nonlinear Sciences, 2020
The exact solution is calculated for fractional telegraph partial differential equation depend on initial boundary value problem. Stability estimates are obtained for this equation. Crank-Nicholson difference schemes are constructed for this problem. The
Mahmut Modanlı, Ali Akgül
semanticscholar   +1 more source

β‐TrCP overexpression enhances cisplatin sensitivity by depleting BRCA1

Molecular Oncology, EarlyView.
Low levels of β‐TrCP (Panel A) allow the accumulation of BRCA1 and CtIP, which facilitate the repair of cisplatin‐induced DNA damage via homologous recombination (HR) and promote tumor cell survival. In contrast, high β‐TrCP expression (Panel B) leads to BRCA1 and CtIP degradation, impairing HR repair, resulting in persistent DNA damage and apoptosis ...
Rocío Jiménez‐Guerrero, Alejandro Belmonte‐Fernández, Mónica González‐Moreno, Laura Rodríguez‐Cordero, Begoña Pérez‐Valderrama, Joaquín Herrero‐Ruíz, Francisco Romero, Carmen Sáez, Miguel Á. Japón   +8 more
wiley   +1 more source

Lie symmetry analysis, conservation laws and exact solutions of the seventh-order time fractional Sawada–Kotera–Ito equation

Results in Physics, 2016
In this paper Lie symmetry analysis of the seventh-order time fractional Sawada–Kotera–Ito (FSKI) equation with Riemann–Liouville derivative is performed.
Emrullah Yaşar, Yakup Yıldırım, Chaudry Masood Khalique   +2 more
doaj   +1 more source

Positive Solutions for Boundary Value Problems of Fractional Differential Equation with Integral Boundary Conditions

, 2018
By using two fixed-point theorems on cone, we discuss the existence results of positive solutions for the following boundary value problem of fractional differential equation with integral boundary conditions: , , , and .
Qiao‐Xi Sun, Hong-Kyu Ji, Yujun Cui
semanticscholar   +1 more source

Adenosine‐to‐inosine editing of miR‐200b‐3p is associated with the progression of high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
A‐to‐I editing of miRNAs, particularly miR‐200b‐3p, contributes to HGSOC progression by enhancing cancer cell proliferation, migration and 3D growth. The edited form is linked to poorer patient survival and the identification of novel molecular targets.
Magdalena Niemira, Anna Skwarska, Karolina Chwialkowska, Agnieszka Ostrowska, Gabriela Sokolowska, Anna Zeller, Anna Erol, Andrzej Eljaszewicz, Bartosz Hanczaruk, Anna Michalska‐Falkowska, Agnieszka Tarasik, Joanna Reszec‐Gielazyn, Pawel Knapp, Marcin Moniuszko, Adam Kretowski   +14 more
wiley   +1 more source

Global Existence and Uniqueness of Solution of Atangana–Baleanu Caputo Fractional Differential Equation with Nonlinear Term and Approximate Solutions

International Journal of Differential Equations, 2021
In this paper, a class of fractional order differential equation expressed with Atangana–Baleanu Caputo derivative with nonlinear term is discussed.
Meryeme Hassouna, El Hassan El Kinani, Abdelaziz Ouhadan   +2 more
doaj   +1 more source

Stability of the fractional Volterra integro‐differential equation by means of ψ‐Hilfer operator [PDF]

Mathematical methods in the applied sciences, 2018
In this paper, using the Riemann‐Liouville fractional integral with respect to another function and the ψ−Hilfer fractional derivative, we propose a fractional Volterra integral equation and the fractional Volterra integro‐differential equation.
J. Sousa, F. G. Rodrigues, E. Capelas de Oliveira   +2 more
semanticscholar   +1 more source

SEPARABLE LOCAL FRACTIONAL DIFFERENTIAL EQUATIONS [PDF]

Fractals, 2016
The concept of local fractional derivative was introduced in order to be able to study the local scaling behavior of functions. However it has turned out to be much more useful. It was found that simple equations involving these operators naturally incorporate the fractal sets into the equations.
openaire   +2 more sources

Tumor and germline testing with next generation sequencing in epithelial ovarian cancer: a prospective paired comparison using an 18‐gene panel

Molecular Oncology, EarlyView.
Genetic testing in epithelial ovarian cancer includes both germline and tumor‐testing. This approach often duplicates resources. The current prospective study assessed the feasibility of tumor‐first multigene testing by comparing tumor tissue with germline testing of peripheral blood using an 18‐gene NGS panel in 106 patients.
Elisabeth Spenard, Cristina Mitric, Melanie Care, Tracy L. Stockley, Raymond H. Kim, Jeanna McCuaig, Blaise Clarke, Laura Ranich, Clare Sheen, Sarah E. Ferguson, Liat Hogen, Taymaa May, Marcus Q. Bernardini   +12 more
wiley   +1 more source