Results 71 to 80 of about 182,739 (283)

( k , φ ) $(\mathtt{k},\varphi )$ -Hilfer fractional Langevin differential equation having multipoint boundary conditions

Boundary Value Problems
The primary objective of this manuscript is to investigate the existence and uniqueness of solutions for the Langevin ( k , φ ) $(\mathtt{k},\varphi )$ -Hilfer fractional differential equation of different orders with multipoint nonlocal fractional ...
HuiYan Cheng, Naila, Akbar Zada, Ioan-Lucian Popa, Afef Kallekh   +4 more
doaj   +1 more source

Stochastic differential equation involving Wiener process and fractional Brownian motion with Hurst index $H> 1/2$

, 2011
We consider a mixed stochastic differential equation driven by possibly dependent fractional Brownian motion and Brownian motion.
Garsia A. M., Georgiy M. Shevchenko, Kleptsyna M., Kubilius K., Nualart D., Samko S., Yulia S. Mishura   +6 more
core   +1 more source

Recurrent cancer‐associated ERBB4 mutations are transforming and confer resistance to targeted therapies

Molecular Oncology, EarlyView.
We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala, Sini Ahonen, Sara Peltola, Aura Tuohisto‐Kokko, Olaya Esparta, Peppi Suominen, Anne Jokilammi, Iman Farahani, Deepankar Chakroborty, Nikol Dibus, Steffen Boettcher, Tomi T. Airenne, Mark S. Johnson, Lisa D. Eli, Klaus Elenius, Kari J. Kurppa   +15 more
wiley   +1 more source

Numerical solution for a class of multi-order fractional differential equations with error correction and convergence analysis

Advances in Difference Equations, 2018
In this article, we investigate numerical solution of a class of multi-order fractional differential equations with error correction and convergence analysis.
Wei Han, Yi-Ming Chen, Da-Yan Liu, Xiao-Lin Li, Driss Boutat   +4 more
doaj   +1 more source

An analytic relation between the fractional parameter in the Mittag-Leffler function and the chemical potential in the Bose-Einstein distribution through the analysis of the NASA COBE monopole data

, 2017
To extend the Bose-Einstein (BE) distribution to fractional order, we turn our attention to the differential equation, $df/dx =-f-f^2$. It is satisfied with the stationary solution, $f(x)=1/(e^{x+\mu}-1)$, of the Kompaneets equation, where $\mu$ is the ...
Biyajima, Minoru, Mizoguchi, Takuya, Suzuki, Naomichi   +2 more
core   +1 more source

Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity

Molecular Oncology, EarlyView.
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung, David Bickel, Lena C. M. Krause, Daria Ezeriņa, Christian Ickes, Julian Wojtachnia, Christine S. Gibhardt, Magdalena Shumanska, Khadija Wahni, Andrea Paluschkiwitz, Julia Malo Pueyo, Ekaterina Baranova, Wim Vranken, Hedwig Stanisz, Ioana Stejerean‐Todoran, Michael P. Schön, Joris Messens, Ivan Bogeski   +17 more
wiley   +1 more source

Crucial parameters for precise copy number variation detection in formalin‐fixed paraffin‐embedded solid cancer samples

Molecular Oncology, EarlyView.
This study shows that copy number variations (CNVs) can be reliably detected in formalin‐fixed paraffin‐embedded (FFPE) solid cancer samples using ultra‐low‐pass whole‐genome sequencing, provided that key (pre)‐analytical parameters are optimized.
Hanne Goris, Vasiliki Siozopoulou, Léon C van Kempen, Anne Sieben, Ella Roelant, Stig Hellemans, Elyne Backx, Laure Sorber, Koen De Winne, Senada Koljenović, Karen Zwaenepoel   +10 more
wiley   +1 more source

Combining antibody conjugates with cytotoxic and immune‐stimulating payloads maximizes anti‐cancer activity

Molecular Oncology, EarlyView.
Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang, Dong Jun Koo, Peter M. Tessier, Greg M. Thurber   +3 more
wiley   +1 more source

Approximate Time‐Fractional Differential Equations

Discrete Dynamics in Nature and Society
This study introduces an indirect approach to find the solutions of the fractional Bessel differential equation using fractional Bernoulli functions and Caputo’s fractional derivative. This method transforms the problem into a nonlinear system of algebraic equations. The existence and uniqueness of the solution for the problem are proved.
Saber Tavan, Mohammad Jahangiri Rad, Ali Salimi Shamloo, Yaghoub Mahmoudi   +3 more
openaire   +2 more sources

Colorectal cancer‐derived FGF19 is a metabolically active serum biomarker that exerts enteroendocrine effects on mouse liver

Molecular Oncology, EarlyView.
Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley, Michael W. Rohr, Joseph A. Goode, Sai Preethi Nakkina, Jignesh G. Parikh, Deborah A. Altomare   +5 more
wiley   +1 more source