Results 81 to 90 of about 2,668,291 (311)

Leucine‐rich glioma inactivated 1 (LGI1) is a ganglioside‐binding protein

FEBS Letters, EarlyView.
Neuronal hyperexcitability associated with a decrease/absence of the extracellular protein LGI1 has been suggested to be primarily due to the downregulation of Kv1 channel expression. The molecular mechanisms underlying this decrease have not yet been elucidated.
Kévin Debreux, Christian Lévêque, Fodil Azzaz, Marion Sangiardi, Sarosh R Irani, Michael Seagar, Jacques Fantini, Oussama El Far   +7 more
wiley   +1 more source

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

Numerical study of fractional model of multi-dimensional dispersive partial differential equation

Journal of Ocean Engineering and Science, 2019
This article is devoted to a newly introduced numerical method for time-fractional dispersive partial differential equation in a multi-dimensional space.
Vijay Verma, Amit Prakash, Devendra Kumar, Jagdev Singh   +3 more
doaj   +1 more source

Combined Liouville–Caputo Fractional Differential Equation

, 2023
This paper studies a fractional differential equation combined with a Liouville–Caputo fractional differential operator, namely, LCDηβ,γQ(t)=λϑ(t,Q(t)),t∈[c,d],β,γ∈(0,1],η∈[0,1], where Q ...
Tijani Abdul-Aziz Apalara, Soh Edwin Mukiawa, McSylvester Ejighikeme Omaba, Cyril Dennis Enyi, Hamdan Al Sulaimani   +4 more
core   +1 more source

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

Analytic solution for the space-time fractional Klein-Gordon and coupled conformable Boussinesq equations

Results in Physics, 2018
In this paper, we constructed a travelling wave solution for space-time fractional nonlinear partial differential equations by using the modified extended Tanh method with Riccati equation.
Muhannad A. Shallal, Hawraz N. Jabbar, Khalid K. Ali   +2 more
doaj   +1 more source

Stability of Caputo fractional differential equations by Lyapunov functions [PDF]

, 2015
summary:The stability of the zero solution of a nonlinear nonautonomous Caputo fractional differential equation is studied using Lyapunov-like functions.
Hristova, Snezhana, O'Regan, Donal, Donal O’Regan, Snezhana Hristova, Ravi Agarwal, Agarwal, Ravi   +5 more
core   +1 more source

A Novel Delay-Dependent Asymptotic Stability Conditions for Differential and Riemann-Liouville Fractional Differential Neutral Systems with Constant Delays and Nonlinear Perturbation [PDF]

, 2020
The novel delay-dependent asymptotic stability of a differential and Riemann-Liouville fractional differential neutral system with constant delays and nonlinear perturbation is studied.
Chartbupapan, Watcharin, Watcharin Chartbupapan, Kanit Mukdasai, Ovidiu Bagdasar, Mukdasai, Kanit, Bagdasar, Ovidiu   +5 more
core   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

SOLVING THE FRACTIONAL DIFFERENTIAL RICCATI EQUATION ARISING FROM THE HESTON MODEL WITH NEURAL NETWORKS AND POWER SERIES EXPANSION

, 2022
reservedIn my work I explore the fractional differential Riccati equation, which is a particular equation that arises in many different mathematical problems. In particular, It arises in the financial stochastic model of Heston, more precisely, the rough
HU, NICOLA
core