Results 81 to 90 of about 20,395 (261)

YIPFα1A expression is regulated by multilayered molecular mechanisms

FEBS Open Bio, EarlyView.
YIPFα1A, a five‐pass Golgi protein, is regulated at multiple layers. (1) Rare‐codon enrichment drives translation‐coupled mRNA decay. (2) A proximal 3′‐UTR element stabilizes mRNA. (3) A distal 3′‐UTR element included by alternate poly(A) site usage represses translation, which can be overridden by the proximal 3′‐UTR element.
Tokio Takaji, Yurika Nakanishi, Nobuhiro Nakamura   +2 more
wiley   +1 more source

Application of piecewise fractional differential equation to COVID-19 infection dynamics. [PDF]

Results Phys, 2022
Li XP, Alrihieli HF, Algehyne EA, Khan MA, Alshahrani MY, Alraey Y, Riaz MB.   +6 more
europepmc   +1 more source

Molecular dynamics simulations of positively selected codons in FcγRI reveal novel biochemical binding properties

FEBS Open Bio, EarlyView.
Evolutionary analysis across 32 placental mammals identified positive selection at residues H148 and W149 in the immune receptor FcγR1. Ancestral reconstruction combined with molecular dynamics simulations reveals how these mutations may influence receptor structure and dynamics, providing insight into the evolution of antibody recognition and immune ...
David A. Young, Omar Arias‐Gaguancela, Fiona Gibson, Morgan Grainger, Jodie Score, Amit Nathubhai, Mauricio Cafiero, Lee Richard Machado   +7 more
wiley   +1 more source

Symmetry Analysis and Wave Solutions of Time Fractional Kupershmidt Equation

Journal of Applied Mathematics
This study employs the Lie symmetry technique to explore the symmetry features of the time fractional Kupershmidt equation. Specifically, we use the Lie symmetry technique to derive the symmetry generators for this equation, which incorporates a ...
Shalu Saini, Rajeev Kumar, Kamal Kumar
doaj   +1 more source

Optimizing photoactivation of PA‐mCherry for optical pooled CRISPR screens

FEBS Open Bio, EarlyView.
Photoactivatable PA‐mCherry finds widespread use to optically tag individual cells. However, confocal 405 nm UV laser‐scanning (normal scan) is much less efficient than widefield UV illumination, limiting the use of PA‐mCherry on confocal instruments. We remedy this limitation by reporting that rapid and repeated confocal scanning with a low‐intensity,
Sravasti Mukherjee, Giulia Zanetti, Bram van den Broek, Kees Jalink   +3 more
wiley   +1 more source

Fractional Ulam-stability of fractional impulsive differential equation involving Hilfer-Katugampola fractional differential operator

Universal Journal of Mathematics and Applications, 2018
In this note, we set up existence, uniqueness as well as the stability of a special class of fractional differential equation (FDE) with Hilfer-Katugampola fractional differential operator (HKFDO). The outcomes are given by employing the Schaefer's fixed
Rabha Ibrahim, S. Harikrishnan, K. Kanagarajan   +2 more
doaj   +1 more source

On the existence and stability of fuzzy CF variable fractional differential equation for COVID-19 epidemic. [PDF]

Eng Comput, 2022
Verma P, Kumar M.
europepmc   +1 more source

A remark on the fractional order differential equations

Journal of Computational and Applied Mathematics, 2018
zbMATH Open Web Interface contents unavailable due to conflicting licenses.
Tie Zhang, Can Tong
openaire   +3 more sources

Acute caffeine treatment protects the developing retina from ischemia‐induced cell death

FEBS Open Bio, EarlyView.
Caffeine reduces cell death in the developing retina under ischemia (OGD). This effect does not involve BDNF upregulation or antioxidant pathways (NRF2/VEGF). Neuroprotection occurs mainly through adenosine A2A receptor antagonism, decreasing glutamate release and excitotoxicity, highlighting caffeine's potential as an acute neuroprotective agent in ...
Amanda Alves Nascimento, Danniel Pereira‐Figueiredo, Gabriella Grossi de Lima Dias, Gabriel Ferreira dos Santos, Mariana Rodrigues Pereira, Rafael Brito, Karin C Calaza   +6 more
wiley   +1 more source

Pharmacological inhibition of the PERK pathway modulates hepatocellular carcinoma growth and immune signaling

FEBS Open Bio, EarlyView.
Pharmacological inhibition of PERK in a DEN‐induced mouse model of liver cancer does not reduce tumor burden but alters cellular stress signaling. Despite blocking PERK activity, downstream stress responses, including CHOP expression, remain active, suggesting compensatory mechanisms within the unfolded protein response that may influence tumor ...
Ada Lerma‐Clavero, Maria Kopsida, Nathalie Arendt, Hans Lennernäs, Markus Sjöblom, Femke Heindryckx   +5 more
wiley   +1 more source