Results 81 to 90 of about 760,461 (313)
Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma
Molecular Oncology, EarlyView.Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken +7 more
wiley +1 more source
Random walk models associated with distributed fractional order differential equations
, 2006 In this paper the multi-dimensional random walk models governed by distributed fractional order differential equations and multi-term fractional order differential equations are constructed. The scaling limits of these random walks to a diffusion process
Steinberg, Stanly, Umarov, Sabir
core +2 more sources
LDAcoop: Integrating non‐linear population dynamics into the analysis of clonogenic growth in vitro
Molecular Oncology, EarlyView.Limiting dilution assays (LDAs) quantify clonogenic growth by seeding serial dilutions of cells and scoring wells for colony formation. The fraction of negative wells is plotted against cells seeded and analyzed using the non‐linear modeling of LDAcoop.
Nikko Brix +13 more
wiley +1 more source
Lyapunov-type inequalities for fractional differential equations: a survey [PDF]
Surveys in Mathematics and its Applications, 2021 A survey of results on Lyapunov-type inequalities for fractional differential equations associated with a variety of boundary conditions is presented.
Sotiris K. Ntouyas, Bashir Ahmad
doaj
Singular fractional differential equations [PDF]
PAMM, 2013 AbstractFractional differential equations have received increasing attention during recent years since the behavior of many physical systems can be properly described using the fractional order system theory.By fractional analog for Duhamel principle we give the existence‐uniqueness result for linear and nonlinear time fractional evolution equations ...
openaire +1 more source
Well-posedness and numerical algorithm for the tempered fractional differential equations
Discrete & Continuous Dynamical Systems - B, 2019 Trapped dynamics widely appears in nature, e.g., the motion of particles in viscous cytoplasm. The famous continuous time random walk (CTRW) model with power law waiting time distribution (having diverging first moment) describes this phenomenon. Because
Can Li, W. Deng, Lijing Zhao
semanticscholar +1 more source
Molecular Oncology, EarlyView.We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala +15 more
wiley +1 more source
Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity
Molecular Oncology, EarlyView.Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung +17 more
wiley +1 more source
, 2018 In this note we show how a initial value problem for a relaxation process governed by a differential equation of non-integer order with a constant coefficient may be equivalent to that of a differential equation of the first order with a varying ...
Mainardi, Francesco
core +2 more sources
Molecular Oncology, EarlyView.This study shows that copy number variations (CNVs) can be reliably detected in formalin‐fixed paraffin‐embedded (FFPE) solid cancer samples using ultra‐low‐pass whole‐genome sequencing, provided that key (pre)‐analytical parameters are optimized.
Hanne Goris +10 more
wiley +1 more source