Results 91 to 100 of about 29,097 (308)

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

open access: yesMolecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu   +10 more
wiley   +1 more source

Generalized quasilinearization for fractional differential equations

open access: yesComputers & Mathematics with Applications, 2010
zbMATH Open Web Interface contents unavailable due to conflicting licenses.
J. Vasundhara Devi   +2 more
openaire   +2 more sources

Interaction of HS1BP3 with cortactin modulates TKS5 localisation, cell secretion and cancer malignancy

open access: yesMolecular Oncology, EarlyView.
Here, we demonstrate that HS1BP3 interacts with Cortactin through a proline‐rich region (PRR3.1) and show that this interaction, and HS1BP3 itself, promote cancer cell proliferation and invasion. Inhibition of this interaction leads to build‐up of TKS5 in multivesicular endosomes and altered secretion of CD63 and CD9, providing an explanation for the ...
Arja Arnesen Løchen   +9 more
wiley   +1 more source

Cauchy Problem for a Linear System of Ordinary Differential Equations of the Fractional Order

open access: yes, 2020
We investigate the initial problem for a linear system of ordinary differential equations with constant coefficients and with the Dzhrbashyan–Nersesyan fractional differentiation operator.
Murat Mamchuev
core   +1 more source

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

open access: yesMolecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura   +19 more
wiley   +1 more source

Solving Undamped and Damped Fractional Oscillators via Integral Rohit Transform

open access: yesAl-Mustansiriyah Journal of Science
Background: The dynamics of fractional oscillators are generally described by fractional differential equations, which include the fractional derivative of the Caputo or Riemann-Liouville type.
Rohit Gupta, Rahul Gupta, Dinesh Verma
doaj   +1 more source

Modified wavelets–based algorithm for nonlinear delay differential equations of fractional order

open access: yesAdvances in Mechanical Engineering, 2017
Most of the physical phenomena located around us are nonlinear in nature and their solutions are of great significance for scientists and engineers. In order to have a better representation of these physical phenomena, fractional calculus is developed ...
Muhammad Asad Iqbal   +3 more
doaj   +1 more source

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

open access: yesMolecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis   +3 more
wiley   +1 more source

On matrix fractional differential equations

open access: yesAdvances in Mechanical Engineering, 2017
The aim of this article is to study the matrix fractional differential equations and to find the exact solution for system of matrix fractional differential equations in terms of Riemann–Liouville using Laplace transform method and convolution product to
Adem Kılıçman, Wasan Ajeel Ahmood
doaj   +1 more source

The double auxiliary equations method and its application to space-time fractional nonlinear equations

open access: yesJournal of Ocean Engineering and Science, 2019
This paper reflects the execution of a reliable technique which we proposed as a new method called the double auxiliary equations method for constructing new traveling wave solutions of nonlinear fractional differential equation.
L.A. Alhakim, A.A. Moussa
doaj   +1 more source

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