Results 91 to 100 of about 120,593 (286)
Subtype‐specific enhancer RNAs define transcriptional regulators and prognosis in breast cancers
Molecular Oncology, EarlyView.This study employed machine learning methodologies to perform the subtype‐specific classification of RNA‐seq data sets, which are mapped on enhancers from TCGA‐derived breast cancer patients. Their integration with gene expression (referred to as ProxCReAM eRNAs) and chromatin accessibility profiles has the potential to identify lineage‐specific and ...
Aamena Y. Patel +6 more
wiley +1 more source
Applied Computer ScienceStationarity is a fundamental assumption in time series modeling that underlies reliable statistical inference and forecasting. Time series data can be found in many domains, including industry, engineering, finance, economics, epidemiology, and health ...
Apollinaire BATOURE BAMANA +3 more
doaj +1 more source
Time-fractional diffusion of distributed order
, 2007 The partial differential equation of Gaussian diffusion is generalized by using the time-fractional derivative of distributed order between 0 and 1, in both the Riemann-Liouville (R-L) and the Caputo (C) sense.
Gorenflo, Rudolf +3 more
core +3 more sources
Molecular Oncology, EarlyView.Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova +25 more
wiley +1 more source
On the stability of some fractional-order non-autonomous systems
Electronic Journal of Qualitative Theory of Differential Equations, 2007 The fractional calculus (integration and differentiation of fractional-order) is a one of the singular integral and integro-differential operators. In this work a class of fractional-order non-autonomous systems will be considered.
Sheren Ahmed Abd El-Salam +1 more
doaj +1 more source
Spectral properties of fractional differentiation operators
, 2019 We consider fractional differentiation operators in various senses and show that the strictly accretive property is the common property of fractional differentiation operators.
Kukushkin, M. V.
core +2 more sources
Targeted modulation of IGFL2‐AS1 reveals its translational potential in cervical adenocarcinoma
Molecular Oncology, EarlyView.Cervical adenocarcinoma patients face worse outcomes than squamous cell carcinoma counterparts despite similar treatment. The identification of IGFL2‐AS1's differential expression provides a molecular basis for distinguishing these histotypes, paving the way for personalized therapies and improved survival in vulnerable populations globally.
Ricardo Cesar Cintra +6 more
wiley +1 more source
Molecular Oncology, EarlyView.Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson +9 more
wiley +1 more source
Vestnik Samarskogo Gosudarstvennogo Tehničeskogo Universiteta. Seriâ: Fiziko-Matematičeskie Nauki, 2011 A non-local problem for a mixed type equation with partial fractional derivative of Riemann-Liouville is studied, boundary condition of which contains generalized operator of fractional integro-differentiation.
Svetlana A Sayganova
doaj +3 more sources
Molecular Oncology, EarlyView.Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau +36 more
wiley +1 more source