Results 51 to 60 of about 16,792 (298)

An unexpected alternative viologen electron mediator site in tungsten‐containing formate dehydrogenase

FEBS Letters, EarlyView.
An unexpected alternative interaction site for ethyl viologen was identified in formate dehydrogenase 1 from Methylorubrum extorquens. Combined mutagenesis, kinetic analysis, and docking revealed that aromatic residues near an iron–sulfur cluster enable flavin mononucleotide‐independent electron transfer, offering a framework for engineering improved ...
Eleni G. Poloniataki, Yong Hwan Kim
wiley   +1 more source

STUDIES OF SAFETY AND FUNCTIONAL AND METABOLIC EFFECTS OF NON-IONIC CONTRAST MEDIA IN CHILDREN WITH NEPHROPATHIES

Педиатрическая фармакология, 2010
A study was conducted to assess the safety of non-ionic contrast media in paediatric nephrourology and their impact onto renal function and homeostasis, reflecting the risk of development of contrast-induced nephropathy.
E.N. Tsygina, I.E. Smirnov, A.G. Kucherenko, G.F. Zadkova, O.F. Lukina, O.O. Kupriyanova, T.E. Sorokina, M.I. Bakanov, S.N. Zorkin, S.P. Yatsyk, A.N. Tsygin   +10 more
doaj   +2 more sources

Effect of inhibition of nitric oxide synthase on blood pressure and renal sodium handling in renal denervated rats

Brazilian Journal of Medical and Biological Research, 2000
The role of sympathetic nerve activity in the changes in arterial blood pressure and renal function caused by the chronic administration of NG-nitro-L-arginine methyl ester (L-NAME), an inhibitor of nitric oxide (NO) synthesis, was examined in sham and ...
F. Xavier, A.M.F. Magalhães, J.A.R. Gontijo   +2 more
doaj   +1 more source

Urinary sodium excretion after gastric bypass surgery

, 2017
Background: Gut-kidney signaling is implicated in sodium homeostasis and thus blood pressure regulation. Roux-en-Y gastric bypass (RYGB) surgery for morbid obesity confers a pronounced and long-lasting blood pressure lowering effect in addition to ...
le Roux, Carel W,, Docherty, Neil G.,, Fändriks, Lars,, Peter Hallersund, Malin Werling, Werling, Malin,, Neil G. Docherty, Carel W. le Roux, Hallersund, Peter,, Lars Fändriks   +9 more
core   +1 more source

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

Assessment of the Correlation Between Renal Function Markers and Serum Ferritin Levels in Thalassemia Patients

International Journal of Clinical Practice
Results: Of the sixty-six patients studied, 3.0% had sickle cell thalassemia, 80.3% had major thalassemia, and 72.7% had intermediate thalassemia. In our study, serum ferritin, 24-h urine protein, and fractional excretion of sodium, calcium, and urine ...
Mohammad Tammadondar, Ali Vatankhah, Niloufar Khatibzade-Nasari   +2 more
doaj   +1 more source

Tamoxifen Decreases Lithium-Induced Natriuresis in Rats With Nephrogenic Diabetes Insipidus

Frontiers in Physiology, 2018
Lithium is widely used in the treatment of bipolar affective disorders, but often causes nephrogenic diabetes insipidus (NDI), a condition characterized by a severe urinary concentrating defect. Lithium-induced NDI is associated with dysregulation of the
Stine Julie Tingskov, Tae-Hwan Kwon, Jørgen Frøkiær, Rikke Nørregaard   +3 more
doaj   +1 more source

Effects of an intravenous infusion of diltiazem on glomerular filtration rate, electrolyte excretion, and urine output in healthy dogs

Journal of Veterinary Internal Medicine, 2022
Background Acute kidney injury (AKI) in dogs has a high case fatality rate. Diltiazem might improve renal function, but effect of intravenous infusion has not been adequately studied in dogs.
Megan D. Kelley, Dorothy A. Thompson‐Butler, Matthew C. Tanner, Justin D. Thomason, William H. Whitehouse   +4 more
doaj   +1 more source

Renin-Angiotensin-Aldosterone System Activation and Diuretic Response in Ambulatory Patients With Heart FailurePlain-Language Summary

Kidney Medicine, 2022
Rationale & Objective: Heart failure treatment relies on loop diuretics to induce natriuresis and decongestion, but the therapy is often limited by diuretic resistance.
Jonathan G. Amatruda, Rebecca Scherzer, Veena S. Rao, Juan B. Ivey-Miranda, Michael G. Shlipak, Michelle M. Estrella, Jeffrey M. Testani   +6 more
doaj   +1 more source

Pre‐analytical optimization of cell‐free DNA and extracellular vesicle‐derived DNA for mutation detection in liquid biopsies

Molecular Oncology, EarlyView.
Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen, Lucrezia De Santis, Bret M. Stephens, Vincent Bernard, Jörg C. Kalff, Lara Braun, Phillipp Leyendecker, Johannes Röttgen, Daniel Weissinger, Anirban Maitra, Paola A. Guerrero, Alexander Semaan   +11 more
wiley   +1 more source