Results 111 to 120 of about 26,752 (329)

Blood pressure effects of SGLT2 inhibitors and GLP‐1 receptor agonists: Mechanisms, trial evidence and Real‐world data

British Journal of Clinical Pharmacology, EarlyView.
SGLT2 inhibitors and GLP‐1 receptor agonists modestly lower blood pressure across diverse patient populations, including those without diabetes. These effects appear largely independent of glycaemic control and offer additive value in high‐risk patients with overlapping comorbidities.
Andrej Belančić, Yusuf Ziya Sener, Marijana Vučković, Joseph Edgar Blais, Almir Fajkić, Emina Sher, Mislav Radić, Josipa Radić   +7 more
wiley   +1 more source

Paediatric development of radiopharmaceutical imaging agents and radioligand therapeutics

British Journal of Clinical Pharmacology, EarlyView.
Abstract This review focuses on the development of radiopharmaceutical imaging agents and radioligand therapeutics for paediatric use. Nuclear medicine plays an important role in the diagnosis and treatment of various childhood conditions, including cancers, infections and brain disorders.
Justin L. Hay, Amandine Manon, Hunter Stephens, S. Y. Amy Cheung, Bart de Keizer, Erik T. te Beek   +5 more
wiley   +1 more source

Real‐World Outcomes of FFRangio‐Guided Treatment for Coronary Artery Disease in Acute Versus Chronic Coronary Syndromes

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease
Background The use of angiogram‐based fractional flow reserve technologies in routine clinical practice is increasing steadily. Available data suggest that it is associated with comparable clinical outcomes compared with wire‐based fractional flow ...
Guy Witberg, Yuetsu Kikuta, Kazuhiro Dan, Hiroyoshi Yokoi, Yutaka Hikichi, Mamoru Nanasato, Toru Tanigaki, Yeela Talmor‐Barkan, Amos Levi, Ran Kornowski, Hitoshi Matsuo   +10 more
doaj   +1 more source

Coronary flow reserve calculated from pressure measurements in humans : Validation with positron emission tomography

, 1994
Background Experimental studies have shown that fractional flow reserve (defined as the ratio of maximal achievable flow in a stenotic area to normal maximal achievable flow) can be calculated from coronary pressure measurements only.
Paulus, Walter J., Sys, Stanislas, Heyndrickx, Guy R, Melin, Jacques, Bol, Anne, PAULUS, WJ, Baudhuin, Thierry, Pijls, Nico H.J., BOL, A, Heyndrickx, G.R., Paulus, Walter J, MELIN, JA, Melin, Jacques A, Melin, J.A., Sys, Stanislas U., PIJLS, NHJ, WIJNS, W, Wijns, W., HEYNDRICKX, GR, Bol, A., Pijls, NHJ Nico, Baudhuin, T., DEBRUYNE, B, Pijls, N.H.J., Bruyne, Bernard De, De Bruyne, Bernard, de Bruyne, B., Wijns, William, Heyndrickx, Guy, BAUDHUIN, T, Sys, Stanislas U   +30 more
core   +1 more source

Patients on statins with elevated transaminases: Frequency of follow‐up creatine kinase testing and gastroenterology referral

British Journal of Clinical Pharmacology, EarlyView.
Abstract Purpose To quantify how often creatine kinase (CK) is measured after newly elevated aminotransferases in statin users, and whether absent CK data are associated with gastroenterology (GI) referrals. Methods Retrospective chart review of adult outpatients on statins with a first alanine/aspartate aminotransferase (ALT/AST) elevation during a 5 ...
Faris Shweikeh, Anas Kartoumah, Rajshri Joshi, Anjali Nadihaan, Mohammed Mouchli, Inderprit Singh   +5 more
wiley   +1 more source

The Value of Optical Coherence Tomography Parameters in Estimating Non-Critical Lesions in Patients with Acute Myocardial Infarction

Journal of Cardiovascular Emergencies
Coronary artery disease (CAD) remains a leading cause of morbidity and mortality worldwide. Accurate assessment of coronary lesion severity is essential for guiding revascularization.
Dragoescu Bogdan, Stan Liviu, Ploscaru Vlad, Calmac Lucian, Mihai Cosmin, Marinescu Mugur, Fotea Nicoleta Popa, Tonu Daniel, Dumitru Alexandra, Stanciulescu Diana, Scafa-Udriste Alexandru   +10 more
doaj   +1 more source

Performance of computed tomography-derived fractional flow reserve using reduced-order modelling and static computed tomography stress myocardial perfusion imaging for detection of haemodynamically significant coronary stenosis

European Heart Journal-Cardiovascular Imaging, 2018
Aims To compare the diagnostic performance of a reduced-order computed tomography-derived fractional flow reserve (CT-FFR) technique derived from luminal deformation and static CT stress myocardial perfusion (CTP).
A. Ihdayhid, Takuya Sakaguchi, J. Linde, M. Sørgaard, K. Kofoed, Yasuko Fujisawa, J. Hislop-Jambrich, N. Nerlekar, J. Cameron, R. Munnur, M. Crosset, Dennis T. L. Wong, S. Seneviratne, B. Ko   +13 more
semanticscholar   +1 more source

Transfersomes with core and surface‐loaded NF‐κB p65 siRNA for enhanced transdermal transfection and effective treatment of psoriasis

BMEMat, EarlyView.
TCPL, a transfersome with Tween 80 and PEI, enables efficient transdermal siNF‐κB delivery, resolving PEI's toxicity issue. It promotes lysosomal escape and effective transfection, silences NF‐κB, modulates immunity, and inhibits angiogenesis, alleviating psoriasis. With good biocompatibility, TCPL holds strong clinical translation potential. Schematic
Hui Xing, Yuhui Yang, Ziyi Zhao, Kai Lv, Yiran Shao, Zhi Zhang, Dong Ma   +6 more
wiley   +1 more source

Clinical and Physiological Predictors of Acetylcholine‐Induced Coronary Spasm in ANOCA/INOCA Patients: A Retrospective Cohort Study

Catheterization and Cardiovascular Interventions, EarlyView.
ABSTRACT Background A substantial proportion of patients with angina and/or ischemia are found to have non‐obstructive coronary arteries (ANOCA/INOCA). Their symptoms can sometimes be explained by coronary microvascular dysfunction and/or vasospasm. Selecting patients for acetylcholine testing remains challenging, and the procedure is not trivial in ...
Jeremie Buri, Aurelia Zimmerli, Thabo Mahendiran, Adil Salihu, Victor Weerts, Olivier Muller, David Meier, Stephane Fournier   +7 more
wiley   +1 more source

Unveiling the Microvasculature: The Index of Microcirculatory Resistance and Its Expanding Role in Cardiovascular Care

Catheterization and Cardiovascular Interventions, EarlyView.
ABSTRACT Index of microcirculatory resistance (IMR) is a cutting‐edge, wire‐based tool that advances the capability assessment of coronary microvascular function. By utilizing distal coronary pressure and mean transit time under maximal hyperemia, IMR delivers consistent, reproducible insights into the microvasculature's dynamic health.
Joanna Sohn, Matthew A. Soderstrom, Ariana Ramirez, John‐Henry Dean, Raj Shah, Debanshu Roy, Kenneth Stone, Ariel Vinas, Bryan Ramsey, Charles Lin, Robert Chilton   +10 more
wiley   +1 more source