Results 101 to 110 of about 26,752 (329)

Effect of the ratio of coronary arterial lumen volume to left ventricle myocardial mass derived from coronary CT angiography on fractional flow reserve.

Journal of cardiovascular computed tomography, 2017
BACKGROUND We hypothesize that in patients with suspected coronary artery disease (CAD), lower values of the ratio of total epicardial coronary arterial lumen volume to left ventricular myocardial mass (V/M) result in lower fractional flow reserve (FFR).
Charles A. Taylor, S. Gaur, J. Leipsic, S. Achenbach, D. Berman, J. Jensen, D. Dey, H. Bøtker, H. Kim, Sophie Khem, A. Wilk, C. Zarins, H. Bezerra, J. Lesser, B. Ko, J. Narula, A. Ahmadi, Kristian A. Øvrehus, F. S. St. Goar, B. de Bruyne, B. Nørgaard   +20 more
semanticscholar   +1 more source

A Dual‐Phase Exosomal Nanotherapy Enhances Continual Efferocytosis by Coordinating Checkpoint Inhibition and Metabolic Reprogramming in Atherosclerosis

Advanced Science, EarlyView.
Here we developed Am@SExo, a dual‐functional engineered exosome that coordinates CD47–SIRPα checkpoint blockade with Arg1 mRNA–mediated metabolic reprogramming. Surface SIRPα promotes recognition of apoptotic cells and plaque targeting, while Arg1 expression enhances arginine–ornithine metabolism, Rac1 activation, and actin remodeling in macrophages ...
Danwen Zheng, Shiteng Cai, Jinfeng Gao, Sheng Zhao, Bohan Wei, Xueyi Weng, Zhengmin Wang, Qiaozi Wang, Qiyu Li, Chengzhi Han, Weiyan Li, Yiwen Tan, Yuyuan Fu, Meng Ji, Zheyong Huang, Yanan Song, Juying Qian, Junbo Ge   +17 more
wiley   +1 more source

Clinical usefulness of instantaneous wave-free ratio for the evaluation of coronary artery lesion with prior myocardial infarction: A multi-center study

International Journal of Cardiology: Heart & Vasculature, 2020
Background: Fractional flow reserve (FFR) is useful for assessing the functional significance of coronary artery stenosis, even in lesions with prior myocardial infarction (pMI).
Shusuke Fukuoka, Tairo Kurita, Akihiro Takasaki, Tomoyuki Nakata, Naoki Fujimoto, Jun Masuda, Kozo Hoshino, Takashi Tanigawa, Sukenari Koyabu, Masaaki Ito, Kaoru Dohi   +10 more
doaj   +1 more source

Zebrafish and CRISPR—A synergistic approach to decipher and cure human diseases

Animal Models and Experimental Medicine, EarlyView.
Zebrafish, with high genetic homology to humans, serves as a powerful vertebrate model for disease modeling and drug discovery. Integration of CRISPR/Cas9 technology enables precise genome editing, facilitating the development of translational models for human diseases.
Manikandan Sivaprakasam, Aashika Raagavi Jeanpierre, Salma Mohammed, Rajesh Srinivasan, Aman Kumar Mohanty   +4 more
wiley   +1 more source

Efficacy and safety outcomes of fractional flow reserve in guiding clinical therapy of non-ST-segment elevation myocardial infarction compared with angiography alone in elderly Chinese patients

, 2016
Zhao Zhang,* Ke Li,* Jinwen Tian Department of Cardiology, Chinese People’s Liberation Army General Hospital and Hainan Branch, Sanya, People’s Republic of China *These authors contributed equally to this work Objective: Fractional ...
Tian J, Zhang Z, Li K
core  

TWEAK/Fn14 Signaling Drives Oxidative Cardiac Injury in Systemic Lupus Erythematosus: Evidence From Patient Biomarker Studies, Lupus Mouse Models, and Cardiomyocyte Assays

Arthritis &Rheumatology, EarlyView.
Objective Cardiac involvement is a major cause of morbidity in systemic lupus erythematosus (SLE). Tumor necrosis factor–like weak inducer of apoptosis (TWEAK) is elevated in SLE, but its contribution to lupus‐associated cardiac injury is unclear. We investigated the role of TWEAK/fibroblast growth factor–inducible 14 (Fn14) signaling in SLE‐related ...
Yale Liu, Zhu Yan, Xueting Peng, Meixuan Li, Juan Wang, Yan Zhang, Xiaoqian Hu, Mingzhu Zhou, Kaixuan Ren, Dan Zhang, Xingyi Guo, Yumin Xia, Huanhuan Huo   +12 more
wiley   +1 more source

Fractional flow reserve of intermediate lesions on collateral donor coronary arteries after myocardial infarction [PDF]

, 2013
Fractional flow reserve (FFR) is the gold standard for the functional assessment of coronary arteries. The aim of this study was to evaluate the relation between angiography, QCA and FFR in borderline lesions on collateral donor coronary arteries.
Vučić Rada, Tasić M., Davidović G., Irić-Ćupić Violeta, Zdravković V., Simić I., Ignjatović V.   +6 more
core   +2 more sources

Diagnostic performance of on-site, CT-derived fractional flow reserve in predicting invasive fractional flow reserve and absolute myocardial blood flow

European Heart Journal - Cardiovascular Imaging
Abstract Background Computed tomography (CT)-derived fractional flow reserve (FFR) improves the diagnostic accuracy of coronary CT angiography (CCTA) but requires off-site transfer of images and long processing times.
J H Soeby, L D Rasmussen, J N Dahl, R R Buechel, S Winther, M Bottcher, A A Giannopoulos   +6 more
openaire   +3 more sources

Prediction of fractional flow reserve with angiographic DILEMMA score

, 2017
Objective: Angiographic assessment of stenosis has limited predictive value for functionally significant lesions compared with fractional flow reserve (FFR). The recently developed angiographic DILEMMA score, which consists of minimal lumen diameter (MLD)
YILMAZ, MEHMET BİRHAN, TURGUT, OKAN ONUR, Beton, Osman, Kaya, Hakki   +3 more
core   +1 more source

Comparison of quantitative flow ratio and fractional flow reserve with myocardial perfusion scintigraphy and cardiovascular magnetic resonance as reference standard. A Dan-NICAD substudy

The International Journal of Cardiovascular Imaging, 2019
Quantitative flow ratio (QFR) and fractional flow reserve (FFR) have not yet been compared head to head with perfusion imaging as reference for myocardial ischemia.
Martin Sejr-Hansen, J. Westra, S. Winther, S. Tu, L. Nissen, L. Gormsen, Steffen Erhard Petersen, J. Ejlersen, C. Isaksen, H. Bøtker, M. Bøttcher, E. Christiansen, N. Holm   +12 more
semanticscholar   +1 more source