Results 101 to 110 of about 3,896,573 (293)

Medium-term follow-up of intermediate coronary stenoses left unrevascularized based on myocardial fractional flow reserve findings

, 2002
Objective - Coronary stenoses of intermediate severity create difficulties in decision making when revascularization is concerned. Myocardial fractional flow reserve (mFFR), an accurate tool to identify physiological significance of individual coronary ...
Boyaci, B, Ozdemir, M, Dortlemez, O, Dortlemez, H, Timurkaynak, T, Cengel, A, Cemri, M, Yalcin, R   +7 more
core   +1 more source

Blood pressure effects of SGLT2 inhibitors and GLP‐1 receptor agonists: Mechanisms, trial evidence and Real‐world data

British Journal of Clinical Pharmacology, EarlyView.
SGLT2 inhibitors and GLP‐1 receptor agonists modestly lower blood pressure across diverse patient populations, including those without diabetes. These effects appear largely independent of glycaemic control and offer additive value in high‐risk patients with overlapping comorbidities.
Andrej Belančić, Yusuf Ziya Sener, Marijana Vučković, Joseph Edgar Blais, Almir Fajkić, Emina Sher, Mislav Radić, Josipa Radić   +7 more
wiley   +1 more source

Paediatric development of radiopharmaceutical imaging agents and radioligand therapeutics

British Journal of Clinical Pharmacology, EarlyView.
Abstract This review focuses on the development of radiopharmaceutical imaging agents and radioligand therapeutics for paediatric use. Nuclear medicine plays an important role in the diagnosis and treatment of various childhood conditions, including cancers, infections and brain disorders.
Justin L. Hay, Amandine Manon, Hunter Stephens, S. Y. Amy Cheung, Bart de Keizer, Erik T. te Beek   +5 more
wiley   +1 more source

Transfersomes with core and surface‐loaded NF‐κB p65 siRNA for enhanced transdermal transfection and effective treatment of psoriasis

BMEMat, EarlyView.
TCPL, a transfersome with Tween 80 and PEI, enables efficient transdermal siNF‐κB delivery, resolving PEI's toxicity issue. It promotes lysosomal escape and effective transfection, silences NF‐κB, modulates immunity, and inhibits angiogenesis, alleviating psoriasis. With good biocompatibility, TCPL holds strong clinical translation potential. Schematic
Hui Xing, Yuhui Yang, Ziyi Zhao, Kai Lv, Yiran Shao, Zhi Zhang, Dong Ma   +6 more
wiley   +1 more source

Acute Hypoglycemia Decreases Myocardial Blood Flow Reserve in Patients With Type 1 Diabetes Mellitus and in Healthy Humans

, 2011
Background-: Hypoglycemia is associated with increased cardiovascular mortality, but the reason for this association is poorly understood. We tested the hypothesis that the myocardial blood flow reserve (MBFR) is decreased during hypoglycemia using ...
Coppini, D V, Walker, J J, Rana, Omar, Coppini, D., Begley, J., Joe Begley, Roxy Senior, Byrne, Christopher D., David V. Coppini, Senior, R., Greaves, Kim, Kim Greaves, Walker, J.J., Rana, O, Kerr, D., Soha Zouwail, Byrne, C D, David Kerr, Jeremy J. Walker, Kerr, David, Begley, J, Christopher D. Byrne, Zouwail, S., Zouwail, S, Senior, R, Omar Rana   +25 more
core   +1 more source

Metal nanostructure‐coupled label‐free localized surface plasmon resonance biosensors for rapid and sensitive disease diagnosis

BMEMat, EarlyView.
LSPR biosensing enables rapid, sensitive, and low‐sample‐volume detection of biomarkers, with broad applications in diagnosing cancer, infectious, and chronic diseases. Advances in nanostructure design, micro/nanofabrication, and microfluidic integration have expanded the potential of LSPR sensors in biomedical diagnostics.
Zhaoxin Geng, Yunfei Sha, Jiongyan Yang, Hongru Yang, Xiao Liang   +4 more
wiley   +1 more source

The Relationship between Thrombolysis in Myocardial Infarction Frame Count and Fractional Flow Reserve in Patients with Moderate Coronary Stenosis Undergoing Coronary Angiography

پزشکی بالینی ابن سینا, 2017
Background and Objective: Thrombolysis in myocardial infarction (TIMI) frame count (TFC) is an objective and quantitative index of coronary flow, and myocardial fractional flow reserve (FFR) is a lesion-specific index for epicardial coronary stenosis ...
A Gholoobi, M Mohammadzadeh Shabestari, A Jamshid Rezaei, VR Dabbagh   +3 more
doaj  

The evaluation of myocardial blood flow with measurement technique to Fractional Flow Reserve in patients with myocardial bridging

, 2002
AMAÇ: Fraksiyonel akım rezervi (Fractional Flow Reserve=FFR), koroner arter darlıklarında miyokardiyal iskeminin fonksiyonel olarak ciddiyetini belirlemede kullanılan bir indekstir.
Oğuz Yavuzgil, Azem Akıllı, Cemil Gürgün, Mehdi Zoghi   +3 more
core  

Glycopolymeric nanoparticles transported by activated platelets protect ischemic myocardium by alleviating PANoptosis through targeting macrophage Dectin‐1

BMEMat, EarlyView.
NP‐SF, designed to target macrophage Dectin‐1 and activated platelets, selectively accumulated in ischemic myocardium, where it was taken up by macrophages after platelet hitchhiking. By inhibiting NLRC5‐related PANoptosis, NP‐SF significantly attenuated pathological damage, and effectively preserved cardiac function in a murine ischemia–reperfusion ...
Guanye Yu, Na Yang, Yan Zhang, Lingxin Peng, Yi Li, Yue Chao, Qinfang Miao, Haikun Qi, Jianhui Zhuang, Weixia Jian, Bingyu Li, Wenhui Peng, Jinghua Chen, Shiyu Gong   +13 more
wiley   +1 more source

Diastolic FFR Versus FFR

JACC: Asia, 2021
Bon-Kwon Koo, MD, PhD, Doyeon Hwang, MD
doaj   +1 more source