Results 81 to 90 of about 4,107,542 (294)

Fractional flow reserve and myocardial perfusion by computed tomography: a guide to clinical application [PDF]

European Heart Journal - Cardiovascular Imaging, 2017
The aim of this paper is to provide a guide to the clinical application of the functional computed tomography (CT) techniques fractional flow reserve (CT FFR) and myocardial perfusion (CTP) in patients presenting for the evaluation of coronary artery disease (CAD). Both techniques have recently been introduced to complement coronary CT angiography (CTA)
Joanne D, Schuijf, Brian S, Ko, Marcelo F, Di Carli, Jacqueline, Hislop-Jambrich, Abdul-Rahman, Ihdayhid, Sujith K, Seneviratne, João A C, Lima   +6 more
openaire   +2 more sources

Restores Aβ Clearance by Overcoming PCSK9–LRP1 Dysregulation and TRIB3‐Mediated Autophagy Blockade in Alzheimer's Disease

Advanced Science, EarlyView.
PCSK9 upregulation in cerebrovascular endothelial cells and microglia destabilizes the Aβ transporter LRP1, while TRIB3‐associated autophagy blockade further limits intracellular Aβ degradation. A RAP‐modified tea‐polyphenol nanoparticle co‐delivers siPCSK9 and siTRIB3 to restore LRP1‐mediated Aβ efflux and autophagy‐dependent degradation, reducing Aβ ...
Jie Miao, Jing Wang, Yankun Li, Haipei Zhang, Yanli Zhang, Qingnian Li, Bo Xiao, Wenhu Zhou, Junhong Guo   +8 more
wiley   +1 more source

Engineered Peptide Self‐Assembled Nanofibers for Enhanced STING Activation: A Promising Nanodelivery Platform for Immunotherapy of Pediatric Solid Tumors

Advanced Science, EarlyView.
An engineered peptide self‐assembled nanofiber platform, designed to replicate STING–cGAMP binding motifs, facilitates pH‐responsive cytosolic delivery of cGAMP, enhances the endoplasmic reticulum with high efficiency, and robustly activates the STING pathway.
Yubin He, Xiao Lu, Chang qing Yang, Ran Zhang, Bo Wan, Xin Ni, Dong Mei   +6 more
wiley   +1 more source

Extracellular Vesicle Packaged TDP43 Derived From ECs Exacerbates Cigarette Tar‐Related Atherosclerosis Progression via Enhancing Macrophage Extracellular Traps

Advanced Science, EarlyView.
Cigarette tar triggers EC‐derived EVs carrying TDP43, which binds VDAC1 to boost MAMs, mitochondrial Ca2+ overload, and METs formation in macrophages, accelerating smoking‐related AS progression, while retinoic acid binds TDP43 to block this pathogenic cascade.
Xinxin Zhu, Yuwu Chen, Wei Meng, Biyi Xu, Junke Mou, Xiaolin Liu, Mengyang Wang, Qishuo Gu, Qianhui Sun, Man Li, Chen Zhao, Ming Zeng, Ying Lv, Boling Yi, Sheng Qu, Xiaoxuan Bai, Ji Li, Xing Luo, Sining Hu, Bo Yu, Haibo Jia   +20 more
wiley   +1 more source

Clinical Outcomes and Cost-Effectiveness of Fractional Flow Reserve-Guided Percutaneous Coronary Intervention in Patients With Stable Coronary Artery Disease: Three-Year Follow-Up of the FAME 2 Trial (Fractional Flow Reserve Versus Angiography for Multivessel Evaluation)

, 2018
BACKGROUND: Previous studies found that percutaneous coronary intervention (PCI) does not improve outcome compared with medical therapy (MT) in patients with stable coronary artery disease, but PCI was guided by angiography alone.
Fearon, William F, Peter Jüni, Jüni, Peter, Hlatky, Mark A, Nico H.J. Pijls, Pijls, Nico H J, Tonino, Pim, Pim Tonino, Mark A. Hlatky, De Bruyne, Bernard, Nishi, Takeshi, Barbato, Emanuele, Boothroyd, Derek B, Bernard De Bruyne, William F. Fearon, Takeshi Nishi, Derek B. Boothroyd, Emanuele Barbato   +17 more
core   +2 more sources

Hypertension as a predictor of adverse cardiac events in patients with borderline fractional flow reserve

, 2007
Objective - The cut-off value myocardial fractional flow reserve (FFRmyo) = 0.75. Other clinical characteristics may affect such treatment decision.
Arslan, Fatih, Timurkaynak, Timur, Cengel, Atiye, van der Heijden, Geert, Kaya, Mehmet G.   +4 more
core   +1 more source

Fractional-Order Windkessel Boundary Conditions in a One-Dimensional Blood Flow Model for Fractional Flow Reserve (FFR) Estimation

, 2023
Recent studies have demonstrated the benefits of using fractional derivatives to simulate a blood pressure profile. In this work we propose to combine a one-dimensional model of coronary blood flow with fractional-order Windkessel boundary conditions ...
Ruslan Yanbarisov, Timur Gamilov
core   +1 more source

Fractional flow reserve in patients with reduced ejection fraction [PDF]

, 2020
Fractional flow reserve (FFR) has never been investigated in patients with reduced ejection fraction and associated coronary artery disease (CAD).
Franco, Danilo, Canciello, Grazia, Colaiori, Iginio, Fournier, Stephane, Van Praet, Frank, Morisco, Carmine, Casselman, Filip, Degrieck, Ivan, Vanderheyden, Marc, Xaplanteris, Panagiotis, De Bruyne, Bernard, Katbeh, Asim, Kodeboina, Monika, Stockman, Bernard, Barbato, Emanuele, Di Gioia, Giuseppe, Fiordelisi, Antonella, Bartunek, Jozef, Pellicano, Mariano, Degrieck, I., Morisco, C., Katbeh, A., Xaplanteris, P., Franco, D., Pellicano, M., Van Praet, F., Casselman, F., Stockman, B., Kodeboina, M., Di Gioia, G., Bartunek, J., Fiordelisi, A., Vanderheyden, M., Canciello, G., Colaiori, I., Fournier, S., De Bruyne, B., Barbato, E.   +37 more
core   +1 more source

A Spatiotemporal Single‐Cell Atlas Uncovers Dysregulated ECM Dynamics and Septal Remodeling Arrest in Human Ventricular Septal Defects

Advanced Science, EarlyView.
Integrating single‐cell and spatial transcriptomics reveals human ventricular septal defect (VSD) as a disease of microenvironmental insufficiency and structural remodeling arrest. Attenuated endothelial‐fibroblast crosstalk, alongside downregulated THBS1/TGF‐β1 and MMP2 signaling networks, impairs the endothelial‐to‐mesenchymal transition (EndoMT) and
Xiaoyuan Zhang, Lun Zhu, Ze Sun, Ruolin Jia, Ziming Wang, Jiayao Zhao, Bohao Liu, Haiqing Xiong, Xiaowei Yu, Yanzhu Yue   +9 more
wiley   +1 more source

Quantitative evaluation improves specificity of myocardial perfusion SPECT in the assessment of functionally significant intermediate coronary artery stenoses: a comparative study with fractional flow reserve measurements

, 2013
Myocardial perfusion SPECT (MPS) is a noninvasive method commonly used for assessment of the hemodynamic significance of intermediate coronary stenoses. Fractional flow reserve (FFR) measurement is a well-validated invasive method used for the evaluation
Timurkaynak, Timur, AKDEMİR, ÜMİT ÖZGÜR, Kocaman, Sinan A., ÜNLÜ, MUSTAFA, Sahiner, Ilgin, ŞAHİNARSLAN, ASİFE   +5 more
core   +1 more source