Results 61 to 70 of about 3,896,573 (293)

Cyclic Mechanical Loading of Cardiomyocytes via Pressure‐Driven Non‐Planar Membrane Deformation in a Bioreactor System

Advanced Science, EarlyView.
In this research article, Mansoor and coworkers present a novel device that applies controlled mechanical stimuli to cardiomyocytes using pressure‐driven membrane deformation. By exposing cells to physiologically and pathologically relevant loading conditions, the platform reproduces distinct structural, functional and molecular responses associated ...
Haris Mansoor, Gabrielle Juul, Jil Patel, Heran Pradhan, Gram Hepner, Jackson Jewell, Mark Bardin, Ryan Slusser, Abigail Glezer, Leda Klouda, Melikhan Tanyeri, Anita Saraf   +11 more
wiley   +1 more source

The relationship between Myocardial SPECT and Fractional Flow Reserve: Is it drifting apart? [PDF]

The International Journal of Cardiovascular Imaging, 2009
In the paper, Tc-99 m sestamibi single photon emission computed tomography for guiding percutaneous coronary intervention in patients with multivessel disease: a comparison with quantitative coronary angiography and fractional flow reserve by Forster et.al.
openaire   +2 more sources

Celastrol‐Loaded Conductive Hydrogel Mitigates Myocardial Ischemia‐Reperfusion Injury and Restores Electrophysiological Function

Advanced Science, EarlyView.
Schematic illustration of the Pluronic F127 diacrylate/gelatin methacryloyl/poly(3,4‐ethylenedioxythiophene):poly(styrenesulfonate)/celastrol hydrogel (FGPC) for localized myocardial ischemia–reperfusion injury treatment. FGPC combines sustained celastrol delivery with PEDOT:PSS‐mediated conductive support to attenuate acute oxidative/inflammatory ...
Shixin Wang, Shaojie Chen, Chengzong Li, Hongyi Cheng, Jincheng Jiao, Xiafeng Peng, Yike Zhang, Wei Sun, Feng Zhang, Chang Cui, Minglong Chen   +10 more
wiley   +1 more source

Computational Analysis of Hemodynamic Indices in Multivessel Coronary Artery Disease in the Presence of Myocardial Perfusion Dysfunction

Computation
Coronary artery disease (CAD) is one of the main causes of death in the world. Functional indices such as fractional flow reserve (FFR), coronary flow reserve (CFR) and instantaneous wave-free ratio (iFR) are used to estimate the severity of CAD ...
Timur Gamilov, Alexander Danilov, Peter Chomakhidze, Philipp Kopylov, Sergey Simakov   +4 more
doaj   +1 more source

Functional assessment of coronary artery disease by intravascular ultrasound and computational fluid dynamics simulation

Revista Portuguesa de Cardiologia, 2014
Clinical trials have shown that functional assessment of coronary stenosis by fractional flow reserve (FFR) improves clinical outcomes. Intravascular ultrasound (IVUS) complements conventional angiography, and is a powerful tool to assess atherosclerotic
Sebastián Carrizo, Xinzhou Xie, Rafael Peinado-Peinado, Angel Sánchez-Recalde, Santiago Jiménez-Valero, Guillermo Galeote-Garcia, Raúl Moreno   +6 more
doaj   +1 more source

The Role of Fractional Flow Reserve in Interventional Treatment of Multivessel Coronary Artery Disease

Український журнал серцево-судинної хірургії, 2022
Selective coronary angiography (CAG) is an invasive diagnostic method for the assessment of the internal lumen and anatomical features of the coronary artery.
Andrii Yu. Gavrylyshyn
doaj   +1 more source

An Implantable Phototriggered Prodrug Depot Patch Enables Actively Programmable Drug Release for Post‐Myocardial Infarction Therapy

Advanced Science, EarlyView.
An implantable phototriggered prodrug depot patch (iPDP) is presented that enables actively programmable drug release post‐implantation. Covalently conjugated prodrug ensures minimal leakage; illumination parameters serve as a code to precisely control dose per release.
Haipeng Lu, Kaicheng Deng, Zhang Zhang, Qirui Wang, Weijing Gao, Liyin Shen, Lei Zhang, Wenting Hu, Yang Zhu, Zhengwei Mao, Tanchen Ren   +10 more
wiley   +1 more source

S100A8/A9‐High Macrophages Activate Intestinal Fibroblasts via mCCL6/hCCL15‐CCR1 Axis to Drive Intestinal Fibrosis in Crohn's Disease

Advanced Science, EarlyView.
S100A8/A9‐high macrophages are markedly enriched in the stenotic intestinal tissue of patients with Crohn's disease. These profibrotic macrophages secrete mCCL6 in a STAT3‐dependent manner. mCCL6 and its human ortholog hCCL15 activate fibroblasts via the CCR1 receptor, thereby driving excessive collagen deposition.
Shu Wang, Jiayun Wang, Junjie Lin, Ziping Ye, Geyujia Zhou, Jingjing Ma, Junjian Sun, Jiang Yu, Yingdi Zhang, Nana Tang, Chunhua Jiao, Xiaojing Zhao, Hongjie Zhang   +12 more
wiley   +1 more source

Diagnostic performance of on-site, CT-derived fractional flow reserve in predicting invasive fractional flow reserve and absolute myocardial blood flow

Journal of Cardiovascular Computed Tomography
CT-derived fractional flow reserve (FFR) improves the diagnostic accuracy of coronary CT angiography (CCTA) but typically requires off-site processing. We evaluated the agreement and diagnostic accuracy of a fast (∼8-min), on-site CT-FFR algorithm against invasive FFR and its correlation with myocardial blood flow.Patients with suspected chronic ...
Jacob Hartmann Søby, Laust Dupont Rasmussen, Jonathan Nørtoft Dahl, Ronny R. Buechel, Simon Winther, Lars Christian Gormsen, Morten Böttcher, Andreas A. Giannopoulos   +7 more
openaire   +4 more sources

The impact of motion correction on quantitatively measured perfusion indices using cardiac-dedicated dynamic CZT-SPECT myocardial perfusion imaging

EJNMMI Physics
Background Dynamic myocardial perfusion imaging (MPI) with cadmium-zinc-telluride (CZT) cardiac-dedicated single-photon emission computed tomography (SPECT) enables the quantification of myocardial blood flow (MBF), myocardial flow reserve (MFR), and non-
Ajay Kumar Chaudhary, Fukai Zhao, Zekun Pang, Jianming Li   +3 more
doaj   +1 more source