Results 71 to 80 of about 3,896,573 (293)

Computed tomography myocardial perfusion vs (15)O-water positron emission tomography and fractional flow reserve [PDF]

, 2016
OBJECTIVES: Computed tomography (CT) can perform comprehensive cardiac imaging. We compared CT coronary angiography (CTCA) and CT myocardial perfusion (CTP) with (15)O-water positron emission tomography (PET) and invasive coronary angiography (ICA) with ...
Cruden, Nicholas L, Uren, Neal, Nicholas L. Cruden, Fletcher, Alison, Marc R. Dweck, Alison Fletcher, Henriksen, Peter A, Michelle C. Williams, Peter A. Henriksen, Golay, Saroj K, Saeed Mirsadraee, Dweck, Marc R, Williams, Michelle C; id_orcid, MacGillivray, Tom; id_orcid, McKillop, Graham, Christophe Lucatelli, Dilip Patel, Nicholas W. Weir, João A. C. Lima, Neal Uren, Mirsadraee, Saeed, Lima, Joao AC, Newby, David E, David E. Newby, Edwin J. R. van Beek, Williams, Michelle C, Tom MacGillivray, MacGillivray, Tom, Graham McKillop, Saroj K. Golay, Lima, João A C, Weir, Nicholas W, Lucatelli, Christophe, John H. Reid, Reid, John H, Patel, Dilip, van Beek, Edwin J R, van Beek, Edwin JR   +37 more
core   +2 more sources

Microenvironment‐Responsive Nanomedicine Enables Vertical Modulation of Mitochondrial Pathological Networks in Myocardial Ischemia–Reperfusion Injury

Advanced Science, EarlyView.
A mitochondria‐targeted, microenvironment‐responsive nanoplatform enables pH/ROS‐triggered co‐delivery of berberine and isoliensinine to orchestrate ROS scavenging, inflammation suppression, and apoptosis inhibition. This vertical modulation of mitochondrial pathological networks preserves mitochondrial function and effectively mitigates myocardial ...
Jue Wang, Jia Zhou, Wenqin Yuan, Tianjiao Zhao, Yunying Huang, Yingci Xia, Yuting Lin, Fei Li, Qiong Huang, Chong Liu, Kelong Ai, Qun Qin   +11 more
wiley   +1 more source

PEAR1 Promotes Glucose Metabolism Reprogramming in Sepsis‐Associated Acute Lung Injury via AARS1‐Mediated HIF‐1α Lactylation

Advanced Science, EarlyView.
This study revealed that a PEAR1/HIF‐1α/ glycolysis/lactate/H3K18la positive feedback loop in PMVECs that drives the development of S‐ALI. Mechanistically, PEAR1 mediates the binding of HIF‐1α to AARS1, leading to the lactylation of HIF‐1α, the primary lactylation site of which is K172.
Shuai Li, Zongqing Lu, Pu Fang, Qingqing Pang, Xianghui Wu, Bo Wang, Min Liang, Jingjing Pan, Haobo Kong, Haijian Cai, Juanjuan Li, Jiaying Kang, Dongsheng Wang, Dunling Xia, Mengmeng Xu, Qinghai You   +15 more
wiley   +1 more source

Coronary flow reserve and fractional flow reserve

, 2007
Coronary flow reserve (CFR) and fractional flow reserve (FFR) are two methods used to provide information for functional significance of coronary artery stenosis.
Ozyol, Ali, YILMAZ, MEHMET BİRHAN
core   +3 more sources

Role of stress in dynamic single-photon emission computed tomography with myocardial perfusion reserve determination in assessing the severity of coronary artery stenosis

Российский кардиологический журнал, 2019
Aim. To assess the role of global and selected scintigraphic scores of myocardial perfusion, blood flow and reserve in the anatomical and functional significance of coronary artery (CA) stenosis.Material and methods.
K. V. Zavadovsky, A. V. Mochula, A. V. Vrublevsky, A. E. Baev, A. N. Maltseva, A. A. Boshchenko   +5 more
doaj   +1 more source

Evaluation of Myocardial Perfusion by Computed Tomography - Principles, Technical Background and Recommendations [PDF]

Arquivos Brasileiros de Cardiologia, 2019
Coronary computed tomography angiography (CCTA) has gained a prominent role in the evaluation of coronary artery disease. However, its anatomical nature does not allow the evaluation of the functional repercussion of coronary obstructions.
Tiago Augusto Magalhães, Roberto Caldeira Cury, Rodrigo Julio Cerci, José Rodrigues Parga Filho, Ilan Gottlieb, Marcelo Souto Nacif, Ibraim Masciarelli Pinto, Carlos Eduardo Rochitte, Fabio Vilas-Boas, Paulo R. Schvartzman   +9 more
doaj   +3 more sources

Fractional flow reserve and myocardial perfusion by computed tomography: a guide to clinical application [PDF]

European Heart Journal - Cardiovascular Imaging, 2017
The aim of this paper is to provide a guide to the clinical application of the functional computed tomography (CT) techniques fractional flow reserve (CT FFR) and myocardial perfusion (CTP) in patients presenting for the evaluation of coronary artery disease (CAD). Both techniques have recently been introduced to complement coronary CT angiography (CTA)
Joanne D, Schuijf, Brian S, Ko, Marcelo F, Di Carli, Jacqueline, Hislop-Jambrich, Abdul-Rahman, Ihdayhid, Sujith K, Seneviratne, João A C, Lima   +6 more
openaire   +2 more sources

Metoprolol does not effect myocardial fractional flow reserve in patients with intermediate coronary stenoses

, 2007
Objective: Myocardial fractional flow reserve (FFR) is utilized to determine the hemodynamic significance of coronary stenoses. We sought to determine the effect, if any, of metoprolol on FFR in patients with coronary stenoses of intermediate ...
Ozdemir, Murat, Timurkaynak, Timur, Cengel, Atiye, Turkoglu, Sedat, Yazici, Guliz Erdem   +4 more
core   +1 more source

A Novel Pak1 Activator Ameliorates ER Stress for HFpEF Therapy

Advanced Science, EarlyView.
Chronic metabolic stress is a major contributor to HFpEF progression. Under prolonged metabolic stress, Pak1 activity becomes impaired, contributing to disrupted ER proteostasis, cardiomyocyte apoptosis, fibrosis, and diastolic dysfunction. Mechanistically, Pak1 overexpression activates the ERK1/2–MNK1–eIF4E signaling axis, promotes translational ...
Honglin Xu, Hongyuan Zhang, Tayyiba Azam, Susanne S. Hille, Yingjuan Liu, Min Zi, Jiaqing Lang, He Yu, Yujia Cao, Bernard D. Keavney, Tamer M. A. Mohamed, Jessica M. Miller, Riham R. E. Abouleisa, Ming Xu, Elizabeth J. Cartwright, Oliver J. Müller, Ming Lei, Xin Wang   +17 more
wiley   +1 more source

PARP Inhibitors plus Anlotinib as Bridging Therapy for Armored CAR‐T Cells in Ovarian Cancer Enhances Infiltration and Antitumor Efficacy

Advanced Science, EarlyView.
This study shows that a PARP inhibitor combined with anlotinib, administered as bridging therapy, preconditions the tumor microenvironment to enhance the infiltration and antitumor activity of subsequently infused CAR‐T cells across preclinical ovarian cancer models, supporting bridging therapy as a promising strategy to address limited CAR‐T cell ...
Huayi Li, Minghua Xiang, Qiuyang Xu, Jiahao Liu, Xiaofei Jiao, Wei Mu, Xiaoying Lv, Kangjia Tao, Yu Xu, Dongchen Zhou, Wenjian Gong, Danmei Yan, Yixin Hu, Sen Xu, Bingbing Zhao, Jundong Li, Yongkang Gai, Guang Hu, Li Zhu, Qinglei Gao, Yong Fang   +20 more
wiley   +1 more source