Results 71 to 80 of about 4,107,542 (294)

Computational Analysis of Hemodynamic Indices in Multivessel Coronary Artery Disease in the Presence of Myocardial Perfusion Dysfunction

Computation
Coronary artery disease (CAD) is one of the main causes of death in the world. Functional indices such as fractional flow reserve (FFR), coronary flow reserve (CFR) and instantaneous wave-free ratio (iFR) are used to estimate the severity of CAD ...
Timur Gamilov, Alexander Danilov, Peter Chomakhidze, Philipp Kopylov, Sergey Simakov   +4 more
doaj   +1 more source

Bone Marrow Macrophage STING Signaling is a Direct Nexus Linking Marrow Adipose Expansion to NAD+ Depletion and Osteogenic Decline in Skeletal Aging

Advanced Science, EarlyView.
This study reveals that during skeletal aging, bone marrow adipocyte‐derived sDPP4 primes STING signaling in macrophages. In combination with mitochondrial DNA, this signaling activates CD38 and depletes local NAD+/NMN, thereby impairing osteogenesis.
Zhichao Li, Kuanhui Gao, Mengjie Wang, Songlin Liang, Dandan Li, Guoqing Tan, Haipeng Xue, Yujie Liu, Peng Zhang, Zhanwang Xu, Wenxiang Cheng, Yongjun Wang, Nianhu Li   +12 more
wiley   +1 more source

Normal fractional flow reserve with a critical stenosis supplying viable myocardium.

, 2012
A high-grade stenosis to viable myocardium typically produces a positive fractional flow reserve. In the present report, a case of subtotal occlusion of a saphenous vein graft to a viable myocardial territory with normal fractional flow reserve is ...
Uretsky, Barry F, Sachdeva, Rajesh, Singla, Sandeep, MD   +2 more
core   +1 more source

Improvement of Fractional Flow Reserve after Percutaneous Coronary Intervention Does Not Necessarily Indicate Increased Coronary Flow [PDF]

, 2019
Coronary flow is expected to increase by epicardial lesion modification after successful percutaneous coronary intervention (PCI) in stable angina. According to the concept of fractional flow reserve (FFR), the improvement in FFR after PCI reflects the ...
Tadashi Murai, Taishi Yonetsu, Tsunekazu Kakuta, Masahiro Hoshino, Eisuke Usui, Rikuta Hamaya, Yoshihisa Kanaji   +6 more
core   +1 more source

Multifunctional Nanovaccine‐Radiotherapy Synergy Drives Anti‐Tumor Immunity via Multi‐Cascade Cell Death for Pancreatic Cancer Therapy

Advanced Science, EarlyView.
Machine‐learning‐driven transcriptomic analysis identifies FSTL3 as a key tumor‐microenvironment regulator in desmoplastic pancreatic adenocarcinoma. A cRGD‐modified liposome co‐loading gemcitabine and siFSTL3 serves as an irradiation‐triggered in situ nanovaccine. It synergizes with radiotherapy to induce ferroptosis and immunogenic cell death through
Chengyi Huang, Yushu Han, Xiang Liu, Chuanhao Wang, Xiaofei Zhu, Di Chen, Yangyang Gong, Liang Chen, Wenjuan Chen, Zhenyuan Miao, Bufu Tang, Huojun Zhang   +11 more
wiley   +1 more source

Diagnostic performance of on-site, CT-derived fractional flow reserve in predicting invasive fractional flow reserve and absolute myocardial blood flow

Journal of Cardiovascular Computed Tomography
CT-derived fractional flow reserve (FFR) improves the diagnostic accuracy of coronary CT angiography (CCTA) but typically requires off-site processing. We evaluated the agreement and diagnostic accuracy of a fast (∼8-min), on-site CT-FFR algorithm against invasive FFR and its correlation with myocardial blood flow.Patients with suspected chronic ...
Jacob Hartmann Søby, Laust Dupont Rasmussen, Jonathan Nørtoft Dahl, Ronny R. Buechel, Simon Winther, Lars Christian Gormsen, Morten Böttcher, Andreas A. Giannopoulos   +7 more
openaire   +4 more sources

Computed tomography myocardial perfusion vs (15)O-water positron emission tomography and fractional flow reserve [PDF]

, 2016
OBJECTIVES: Computed tomography (CT) can perform comprehensive cardiac imaging. We compared CT coronary angiography (CTCA) and CT myocardial perfusion (CTP) with (15)O-water positron emission tomography (PET) and invasive coronary angiography (ICA) with ...
Cruden, Nicholas L, Uren, Neal, Nicholas L. Cruden, Fletcher, Alison, Marc R. Dweck, Alison Fletcher, Henriksen, Peter A, Michelle C. Williams, Peter A. Henriksen, Golay, Saroj K, Saeed Mirsadraee, Dweck, Marc R, Williams, Michelle C; id_orcid, MacGillivray, Tom; id_orcid, McKillop, Graham, Christophe Lucatelli, Dilip Patel, Nicholas W. Weir, João A. C. Lima, Neal Uren, Mirsadraee, Saeed, Lima, Joao AC, Newby, David E, David E. Newby, Edwin J. R. van Beek, Williams, Michelle C, Tom MacGillivray, MacGillivray, Tom, Graham McKillop, Saroj K. Golay, Lima, João A C, Weir, Nicholas W, Lucatelli, Christophe, John H. Reid, Reid, John H, Patel, Dilip, van Beek, Edwin J R, van Beek, Edwin JR   +37 more
core   +2 more sources

An Extracellular Pore‑Targeting Peptide Defines a Designable Allosteric Site in TRPV2

Advanced Science, EarlyView.
Structure‐guided peptide engineering yields Depiv2, a highly potent and subtype‐selective TRPV2 inhibitor that binds to the extracellular pore and remodels it into a closed, non‐conductive state. Depiv2 suppresses pathological cardiac hypertrophy, establishing the TRPV2 outer pore as a designable interface for selective peptide modulation.
Aiqin Zhu, Hongkun Wang, Jiawei Wang, Xiaolu Liu, Aerziguli Aierken, Lizhen Xu, Ping Liang, Fan Yang   +7 more
wiley   +1 more source

The unbearable lightness of the instantaneous wave-free ratio/fractional flow reserve discordance

, 2022
The unbearable lightness of the instantaneous wave-free ratio/fractional flow reserve ...
Matteo Tebaldi, Campo G., Gianluca Campo, Tebaldi M.   +3 more
core   +1 more source

Aspirin‐Derived Salicyl‐CoA Drives Histone Lysine Salicylation Regulated by CBP and SIRT2

Advanced Science, EarlyView.
Aspirin‐derived salicyl‐CoA serves as a previously unrecognized acyl donor for protein lysine salicylation. This study identifies histone lysine salicylation as a reversible epigenetic modification regulated by CBP and SIRT2, expanding the biochemical actions of aspirin beyond its canonical acetylation‐dependent mechanisms and providing a new framework
Facai Zhang, Chuanzan Zhou, Jiaoyan He, Pengpeng Huang, Rong Zhang, Huan Hu, Meng Jiao, Linyi Hu, Feng Liu, Xiaolong Qi, Xiang He, Yunkai Yang, Y Eugene Chinn, Dechao Feng, Dahong Zhang, Qi Zhang   +15 more
wiley   +1 more source