Results 171 to 180 of about 17,442 (284)

Microvascular obstruction in cardiac amyloidosis

European Journal of Heart Failure, EarlyView.
Abstract Aims Cardiac amyloidosis (CA) is characterized by deposition of amyloid fibrils within the extracellular space, causing disarray of the myocardial structure and capillary architecture. This study aims to characterize the prevalence of microvascular obstruction (MVO) in patients with CA and to assess the association between MVO and prognosis ...
Lucrezia Netti, Adam Ioannou, Ana Martinez‐Naharro, Yousuf Razvi, Aldostefano Porcari, Lucia Venneri, Viviana Maestrini, Dan Knight, Ruta Virsinskaite, Muhammad U. Rauf, Tushar Kotecha, Rishi K. Patel, Ashutosh Wechelakar, Helen Lachmann, Peter Kellman, Charlotte Manisty, James Moon, Philip N. Hawkins, Julian D. Gillmore, Marianna Fontana   +19 more
wiley   +1 more source

Spermidine supplementation influences mitochondrial number and morphology in the heart of aged mice

Journal of Anatomy, Volume 242, Issue 1, Page 91-101, January 2023., 2023
Aging was associated with hypertrophy of left venticular myocardium in mice without an increase in mitochondrial number. Spermidine treatment increased the number of cardiomyocyte mitochondria significantly. The three‐dimensional ultrastructure of mitochondria showed signs of disarrangement in aged mice which was reduced by spermidine treatment ...
Jil Messerer, Christoph Wrede, Julia Schipke, Christina Brandenberger, Mahmoud Abdellatif, Tobias Eisenberg, Frank Madeo, Simon Sedej, Christian Mühlfeld   +8 more
wiley   +1 more source

Preventive catheter ablation for ventricular arrhythmias in patients with end‐stage heart failure referred for heart transplantation evaluation: Rationale for and design of the CASTLE‐VT trial

European Journal of Heart Failure, EarlyView.
Aims Timely referrals for transplantation and left ventricular assist device (LVAD) play a key role in favourable outcomes in patients with advanced heart failure (HF). Cardiovascular mortality, driven by sudden cardiac death, is the main reason for dying while waiting for heart transplantation (HTx). The purpose of the Preventive Catheter Ablation for
Christian Sohns, Thomas Fink, Harry J.G.M. Crijns, Angelika Costard‐Jaeckle, Nassir F. Marrouche, Samuel Sossalla, Rene Schramm, Mustapha El Hamriti, Maximilian Moersdorf, Maxim Didenko, Martin Braun, Vanessa Sciacca, Frank Konietschke, Volker Rudolph, Jan Gummert, Jan G.P. Tijssen, Philipp Sommer, for the CASTLE‐VT Investigators   +17 more
wiley   +1 more source

The right ventricle under pressure: Anatomy and imaging in sickness and health

Journal of Anatomy, Volume 242, Issue 1, Page 17-28, January 2023., 2023
The RV is essential to the homeostasis of normal physiology and disturbances in RV structure and function has a substantial effect on patient outcomes. This review sets out to describe the developmental and anatomical complexities of the right ventricle while exploring the modern techniques employed to image and understand its function from a clinical ...
Harrison Stubbs, Alexander MacLellan, Stephanie Lua, Helen Dormand, Colin Church   +4 more
wiley   +1 more source

Update on preclinical models of cancer therapy‐related cardiac dysfunction: Challenges and perspectives. A scientific statement of the Heart Failure Association (HFA) of the ESC, the ESC Council of Cardio‐Oncology, and the ESC Working Group on Cellular Biology of the Heart

European Journal of Heart Failure, EarlyView.
New anticancer therapies with potential cardiovascular side effects are continuously being introduced into clinical practice, with new and often unexpected toxicities becoming apparent only after clinical introduction. These unknown toxicities should be identified and understood beforehand to better prepare patients and physicians, enabling the ...
Alessandra Ghigo, Pietro Ameri, Aarti Asnani, Edoardo Bertero, Rudolf A. de Boer, Dimitrios Farmakis, Arantxa González, Stephane Heymans, Borja Ibáñez, Teresa López‐Fernández, Alexander R. Lyon, Piero Pollesello, Amina Rakisheva, Konstantinos Stellos, Katrin Streckfuss‐Bömeke, Carlo Gabriele Tocchetti, Thomas Thum, Peter van der Meer, Eva Van Rooij, Piotr Ponikowski, Marco Metra, Giuseppe Rosano, Sophie Van Linthout   +22 more
wiley   +1 more source

A European update on transcatheter aortic valve implantation (TAVI) in the COVID era

Journal of Anatomy, Volume 242, Issue 1, Page 50-63, January 2023., 2023
A timely review of key Transcatheter Aortic Valve Implantation (TAVI) device trials delineated by surgical risk. Abstract Minimally invasive approaches for aortic valve replacement are now at the forefront of pathological aortic valve treatment. New trials show comparability of these devices to existing therapies, not only in high‐risk surgical cohorts
Ishan Antony, Hyab Mehari Abraha, Aamir Hameed, Claire Conway   +3 more
wiley   +1 more source

Diastolic FFR Versus FFR

JACC: Asia, 2021
Bon-Kwon Koo, MD, PhD, Doyeon Hwang, MD
doaj  

Corrigendum: Correlation between CT-derived fractional flow reserve and myocardial strain in ischemic heart disease patients with single coronary artery stenosis assessed based on CCTA. [PDF]

Front Cardiovasc Med
Ren R, Li W, Zhao Q, Qi C, Zhang X, Peng M, Su D, Han P, Zhang Y.   +8 more
europepmc   +1 more source

Pharmacokinetics of a single dose of Aficamten (CK‐274) on cardiac contractility in a A31P MYBPC3 hypertrophic cardiomyopathy cat model

Journal of Veterinary Pharmacology and Therapeutics, Volume 46, Issue 1, Page 52-61, January 2023., 2023
Abstract Hypertrophic cardiomyopathy (HCM) is the most prevalent cardiac disease in cats and lacks efficacious preclinical pharmacologic intervention, prompting investigation of novel therapies. Genetic mutations encoding sarcomeric proteins are implicated in the development of HCM and small molecule myosin inhibitors are an emerging class of ...
Ashley N. Sharpe, Maureen S. Oldach, Joanna L. Kaplan, Victor Rivas, Samantha L. Kovacs, Darren T. Hwee, Bradley P. Morgan, Fady I. Malik, Samantha P. Harris, Joshua A. Stern   +9 more
wiley   +1 more source

Prospective comparisons of three interpretation methods of fractional flow reserve derived from coronary computed tomography angiography. [PDF]

Quant Imaging Med Surg
Xu K, Yang L, Zhang J, Huang W, Hu Y, Leng X, Liu Y, Liu X, Jin H, Tang Y, Wang J, Guo Y, Ye C, Zhang J, Xiang J, Tang L, Du C.   +16 more
europepmc   +1 more source