Results 181 to 190 of about 8,717 (246)

A geriatrician's approach to managing the complex older adult with obesity

Obesity, EarlyView.
Abstract The prevalence of obesity in older adults is rapidly increasing due to the demographic shift occurring globally. Older adults with obesity face health care challenges due to multimorbidity, functional dependency, and disability. This population often has prior history of struggles through weight‐loss attempts during the middle years of life ...
Shenbagam Dewar
wiley   +1 more source

Coronary CTA-Guided Bifurcation PCI: Role of FFR_CT Virtual PCI and Myocardial Mass for Preprocedural Planning. [PDF]

JACC Case Rep
Carvalho PEP, Cavalcante JL, Lesser J, Cheng V, Strepkos D, Alexandrou M, Mutlu D, Brilakis ES, Sandoval Y.   +8 more
europepmc   +1 more source

Mitigating Trastuzumab‐Doxorubicin Cardiotoxicity With Multiscale Quantitative Systems Toxicology and PBPK‐Toxicodynamic Predictive Modeling Framework

CPT: Pharmacometrics &Systems Pharmacology, EarlyView.
ABSTRACT Doxorubicin (DOX) and trastuzumab (TmAb) are widely used to treat HER2‐positive breast cancer (BC), as monotherapies and in combination (DOX + TmAb). While highly effective, their combined use significantly increases the risk of irreversible cardiotoxicity, posing a major clinical concern.
Sijia Yu, Hardik Mody, Tanaya R. Vaidya, Leonid Kagan, Sihem Ait‐Oudhia   +4 more
wiley   +1 more source

Incremental value of physiological indices to predict high-risk plaques detected by NIRS-IVUS. [PDF]

Cardiovasc Interv Ther
Kakehi K, Ueno M, Yamada N, Onishi K, Sugimoto K, Funauchi Y, Kawamura T, Fujita K, Matsuzoe H, Matsumura K, Nakazawa G.   +10 more
europepmc   +1 more source

Lung‐Derived Small Extracellular Vesicles Containing miR‐15a‐5p/miR‐96‐5p Promote Myocardial Fibrosis in Hypertrophic Cardiomyopathy via Targeting SMAD7

Small, EarlyView.
Small extracellular vesicles (sEVs) are critical regulators of inter‐tissue communication in cardiovascular diseases. In this study, it is found that lung‐derived sEVs enhance cardiac fibroblasts activation and aggravates myocardial fibrosis progression in hypertrophic cardiomyopathy (HCM). sEVmiR‐15a‐5p and sEVmiR‐96‐5p exert this effect via targeting
Minwen Long, Jinpeng Sun, Dongli Zhou, Can Chen, Jiangcheng Shu, Xiaobo Mao, Kunwu Yu, Minglu Liang, Long Chen, Yumei Wang, Min Cheng   +10 more
wiley   +1 more source

Diagnostic performance of target vs. vessel μFR in stable coronary artery disease. [PDF]

BMC Cardiovasc Disord
Huang W, Liu Y, Wang Q, Jin H, Tang Y, Wang J, Liu X, Guo Y, Ye C, Tang L, Du C.   +10 more
europepmc   +1 more source

Foetal Cardiac Function in Early Labour and Intrapartum Outcomes: A Prospective Observational Study

BJOG: An International Journal of Obstetrics &Gynaecology, EarlyView.
ABSTRACT Objective To assess foetal myocardial deformation in normo‐oxygenated foetuses in early labour and its relationship with intrapartum outcomes. Design Single centre prospective study. Setting Referral tertiary maternity unit. Population Uncomplicated singleton term pregnancies in early labour.
Andrea Dall'Asta, Chiara Melito, Beatrice Valentini, Mariagrazia Capurso, Maria Teresa Baffa, Olga Patey, Basky Thilaganathan, Tullio Ghi   +7 more
wiley   +1 more source

The safety profile of deferred revascularization in patients with coronary artery disease undergoing non-hyperemic functional assessments. [PDF]

Postepy Kardiol Interwencyjnej
Błaziak M, Urban S, Wietrzyk W, Jura M, Świerczek I, Kuliczkowski W.   +5 more
europepmc   +1 more source

Nicotinamide Riboside Supplementation Benefits in Patients With Werner Syndrome: A Double‐Blind Randomized Crossover Placebo‐Controlled Trial

Aging Cell, EarlyView.
Nicotinamide riboside improved arterial stiffness (cardio–ankle vascular index), reduced skin ulcer area, and showed a trend toward mitigating heel pad thinning in patients with Werner syndrome, with no serious adverse events. Metabolomic analysis revealed a significant decrease in creatinine, suggesting a potential suppression of renal functional ...
Mayumi Shoji, Hisaya Kato, Masaya Koshizaka, Hiyori Kaneko, Yusuke Baba, Takahiro Ishikawa, Naoya Teramoto, Daisuke Kinoshita, Ayano Yamaguchi, Yukari Maeda, Yosuke Inaba, Yuki Shiko, Yoshihito Ozawa, Vilhelm A. Bohr, Yoshiro Maezawa, Koutaro Yokote   +15 more
wiley   +1 more source

Association between post-PCI vessel fractional flow reserve (vFFR) and optical coherence tomography (OCT) findings: Results from the FAST OCT study. [PDF]

Int J Cardiol Heart Vasc
Ziedses des Plantes AC, Scoccia A, Groenland FTW, Tovar Forero MN, Tomaniak M, Kochman J, Wojakowski W, Gąsior P, Ameloot K, Adriaenssens T, den Dekker WK, Nuis RJ, Kardys I, Van Mieghem NM, Spitzer E, Daemen J.   +15 more
europepmc   +1 more source