Results 161 to 170 of about 1,361,829 (303)

Treatment with KCL‐286, a first‐in‐class retinoic acid receptor‐β (RARβ) agonist, ameliorates neuronal DNA damage and inflammation in a mouse model of Alzheimer's disease

FEBS Open Bio, EarlyView.
Repair of neuronal DNA damage in Alzheimer's disease by KCL‐286. (A) Amyloid‐β oligomers and plaques impair neuronal DNA repair pathways, leading to DNA double‐strand breaks and glial activation. (B) KCL‐286 activates RARβ/RXR signalling via retinoic acid response elements (RAREs), associated with increased BRCA1 expression, enhanced DNA repair and ...
Natasha Hill, Hassan Yousef Othman AlMuallim, Elouisa Maddock, Carl Hobbs, Earl Clarke, Maria B. Goncalves, Jonathan P. T. Corcoran   +6 more
wiley   +1 more source

Importin 7 mediates the nuclear import of HIV‐1 integrase via a specific interacting interface

FEBS Open Bio, EarlyView.
HIV‐1 integrase enables viral DNA integration into the host genome. By binding to the core domain of the host protein Importin 7 via its C‐terminal domain, the integrase is transported across the nuclear membrane into the nucleus, where integration of the viral genome into host DNA takes place. This translocation is a critical step for subsequent viral
Juana Bana, Avigail Yariv, Tal Oppenheim, Hadar Amartely, Dana Reichmann, Oded Livnah   +5 more
wiley   +1 more source

k-fractional integral trapezium-like inequalities through [Formula: see text]-convex and [Formula: see text]-convex mappings. [PDF]

J Inequal Appl, 2017
Wang H, Du T, Zhang Y.
europepmc   +1 more source

Fractional Integral Inequalities via Hadamard’s Fractional Integral [PDF]

, 2017
Bashir Ahmad, Ahmed Alsaedi, Sotiris K. Ntouyas, Jessada Tariboon   +3 more
openaire   +1 more source

Ionomycin suppresses cancer cell growth by disrupting mitochondrial transcription

FEBS Open Bio, EarlyView.
In this study, we identify a new function for the selective Ca2+ ionophore, ionomycin, as an inhibitor of mitochondrial transcription. Both total and nascent RNA analyses revealed that ionomycin treatment reduces the transcription of mitochondrial genes.
Lishen Wang, Mingqiang Deng, Dongmei He, Diqin Lai, Dongjun Liu, Dengyong Zhu, Zhenhua Zhang, Peng Tang, Chuanman Zhou, Menghui Yin, Xichen Bao   +10 more
wiley   +1 more source

Grüss-type inequalities involving functional bounds via analytic kernel fractional integral. [PDF]

MethodsX
Neamah MK, Ibrahim A, Aljaaidi TA, Abdo MS.   +3 more
europepmc   +1 more source

Generalizations of some fractional integral inequalities via generalized Mittag-Leffler function. [PDF]

J Inequal Appl, 2017
Abbas G, Khan KA, Farid G, Rehman AU.
europepmc   +1 more source

KDAC6 alters cell morphology and motility through positive and negative modulation of F‐actin distribution

FEBS Open Bio, EarlyView.
KDAC6 has been associated with cell motility and actin structures, but specific domain contributions are not established. The two catalytic domains have differential effects on motility and F‐actin regulation, affecting cortical F‐actin density, motility, stress fibers, and cell spreading.
Taylor V. Joseph, Andrea B. Pham, Kiara E. Bornes, Razan H. Hammad, Chelsea A. Rousseve‐Ross, Thomas M. Huckaba, Terry J. Watt, Tasha B. Toro   +7 more
wiley   +1 more source

Some new applications of the fractional integral and four-parameter Mittag-Leffler function. [PDF]

PLoS One
Abubaker AA, Matarneh K, B Al-Shaikh S, Khan MF.   +3 more
europepmc   +1 more source

Refined Hermite-Hadamard Type Inequalities via the Extended Atangana-Baleanu Fractional Integral

In this study, we obtain new Hermite-Hadamard type inequalities involving an extended form of the Atangana-Baleanu fractional integral operator having Mittag-Leffler kernels.
Alqahtani, Rubayyi T., Sarikaya, Mehmet Zeki, Alharthi, Nadiyah Hussain   +2 more
core   +1 more source