Results 111 to 120 of about 1,795,890 (245)

A New k-Fractional Integral Operators and their Applications

open access: yes, 2021
In this paper, we present a new k-fractional integral oper-ators involvingparameters °; ¸ analogous to the Riemann-Liouville k-fractional integral.
Ghulam Farid; Department of Mathematics, University of Agriculture Faisalabad,   +1 more
core  

Directed evolution of enzymes at the crossroads of tradition and innovation

open access: yesFEBS Open Bio, EarlyView.
An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova   +2 more
wiley   +1 more source

Inequalities for a Unified Integral Operator and Associated Results in Fractional Calculus

open access: yesIEEE Access, 2019
Integral operators are useful in real analysis, mathematical analysis, functional analysis and other subjects of mathematical approach. The goal of this paper is to study a unified integral operator via convexity.
Young Chel Kwun   +5 more
doaj   +1 more source

Condition number estimates for combined potential boundary integral operators in acoustic scattering [PDF]

open access: yes, 2009
We study the classical combined field integral equation formulations for time-harmonic acoustic scattering by a sound soft bounded obstacle, namely the indirect formulation due to Brakhage-Werner/Leis/Panic, and the direct formulation associated with the
Chandler-Wilde, Simon Neil   +9 more
core   +1 more source

Small RNA pathways in mammalian oocytes

open access: yesFEBS Open Bio, EarlyView.
Three distinct small RNA pathways operate in mammalian oocytes: RNAi interference (RNAi), the microRNA (miRNA) pathway, and the PIWI‐associated RNA (piRNA) pathway. These pathways use small RNAs to guide sequence‐specific repression and contribute to oocyte biology by targeting genes and mobile elements or appear insignificant since different ...
Petr Svoboda, Josef Pasulka
wiley   +1 more source

Transcripts enriched in codons that trigger P‐site tRNA‐mediated mRNA decay possess stable mRNA

open access: yesFEBS Open Bio, EarlyView.
PTMD codons were first described by Mendel et al. as mediators of an mRNA decay pathway dependent on the human protein CNOT3, homologous to yeast Not5. Our findings confirm that PTMD codons destabilize transcripts; however, unlike in yeast, the human pathway specifically targets and slightly destabilizes primarily stable mRNAs.
Rodolfo Lopes Carneiro   +1 more
wiley   +1 more source

From energy provision to protein synthesis: Tunnelling nanotubes as mediators of intercellular metabolic cooperation in cancer

open access: yesFEBS Open Bio, EarlyView.
The cytoskeleton‐mediated transport of mitochondria via tunnelling nanotubes restores respiration, increases ATP production, rescues cells from apoptosis, activates the AKT/mTOR signalling pathway, promotes cell migration and invasiveness, contributes to cancer progression and treatment resistance.
Stanislava Martínková, Jan Trnka
wiley   +1 more source

On weighted generalized fractional and Hardy-type operators acting between Morrey-type spaces

open access: yes, 2017
We study weighted generalized Hardy and fractional operators acting from generalized Morrey spaces Lp,φ,(n) into Orlicz-Morrey spaces LΦ,φ,(n). We deal with radial quasi-monotone weights and assumptions imposed on weights are given in terms of Zigmund ...
Natasha Samko   +3 more
core   +1 more source

Treatment with KCL‐286, a first‐in‐class retinoic acid receptor‐β (RARβ) agonist, ameliorates neuronal DNA damage and inflammation in a mouse model of Alzheimer's disease

open access: yesFEBS Open Bio, EarlyView.
Repair of neuronal DNA damage in Alzheimer's disease by KCL‐286. (A) Amyloid‐β oligomers and plaques impair neuronal DNA repair pathways, leading to DNA double‐strand breaks and glial activation. (B) KCL‐286 activates RARβ/RXR signalling via retinoic acid response elements (RAREs), associated with increased BRCA1 expression, enhanced DNA repair and ...
Natasha Hill   +6 more
wiley   +1 more source

Refinements of Pólya-SzegŐ and Chebyshev type inequalities via different fractional integral operators

open access: yesHeliyon
Various differential and integral operators have been introduced and applied for the generalization of several integral inequalities. The purpose of this article is to create a more generalized fractional integral operator of Saigo type.
Ayyaz Ahmad, Matloob Anwar
doaj   +1 more source

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