Results 101 to 110 of about 1,795,890 (245)

Single‐cell DNA methylation profiling: Technologies, computation, and applications in precision oncology

open access: yesMolecular Oncology, EarlyView.
Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley   +1 more source

On the Behaviors of Rough Fractional Type Sublinear Operators on Vanishing Generalized Weighted Morrey Spaces

open access: yesInternational Journal of Analysis and Applications, 2019
The aim of this paper is to get the boundedness of rough sublinear operators generated by fractional integral operators on vanishing generalized weighted Morrey spaces under generic size conditions which are satisfied by most of the operators in harmonic
Ferit Gurbuz
doaj   +2 more sources

On the Theory of Multilinear Singular Operators with Rough Kernels on the Weighted Morrey Spaces

open access: yesJournal of Function Spaces, 2016
We study some multilinear operators with rough kernels. For the multilinear fractional integral operators TΩ,αA and the multilinear fractional maximal integral operators MΩ,αA, we obtain their boundedness on weighted Morrey spaces with two weights Lp,κ(u,
Sha He, Xiangxing Tao
doaj   +1 more source

Intrapatient tumour heterogeneity and clonal evolution in an autopsy study of metastatic salivary gland cancer

open access: yesMolecular Oncology, EarlyView.
Tumour heterogeneity and clonal evolution of metastatic salivary gland cancer were evaluated in two patients with adenoid carcinoma and one patient with myoepithelial carcinoma. Radiology‐guided autopsy enabled multi‐region sampling (total samples n = 149), followed by whole‐genome sequencing and phylogenetic reconstruction (17 tumour samples, 4–7 per ...
Gerben Lassche   +10 more
wiley   +1 more source

On weighted inequalities for certain fractional integral operators [PDF]

open access: yesInternational Journal of Mathematics and Mathematical Sciences, 2006
This paper considers the modified fractional integral operators involving the Gauss hypergeometric function and obtains weighted inequalities for these operators. Multidimensional fractional integral operators involving the H‐function are also introduced.
openaire   +3 more sources

Automated FRAP microscopy for high‐throughput analysis of protein dynamics in chromatin organization and transcription

open access: yesFEBS Open Bio, EarlyView.
RoboMic is an automated confocal microscopy pipeline for high‐throughput functional imaging in living cells. Demonstrated with fluorescence recovery after photobleaching (FRAP), it integrates AI‐driven nuclear segmentation, ROI selection, bleaching, and analysis.
Selçuk Yavuz   +6 more
wiley   +1 more source

A light‐triggered Time‐Resolved X‐ray Solution Scattering (TR‐XSS) workflow with application to protein conformational dynamics

open access: yesFEBS Open Bio, EarlyView.
Time‐resolved X‐ray solution scattering captures how proteins change shape in real time under near‐native conditions. This article presents a practical workflow for light‐triggered TR‐XSS experiments, from data collection to structural refinement. Using a calcium‐transporting membrane protein as an example, the approach can be broadly applied to study ...
Fatemeh Sabzian‐Molaei   +3 more
wiley   +1 more source

Analysis of some localized boundary-domain integral equations [PDF]

open access: yes, 2009
Some direct segregated localized boundary-domain integral equation (LBDIE) systems associated with the Dirichlet and Neumann boundary value problems (BVP) for a scalar "Laplace" PDE with variable coefficient are formulated and analysed. The parametrix is
Mikhailov, SE   +2 more
core   +3 more sources

The Boundedness for k-th Order Commutators of Fractional Integral Operators with Variable Kernels

open access: yesMathematics
Commutators of fractional integral operators play an important role in harmonic analysis due to their close connections with function regularity and partial differential equations.
Weitao Hu, Dashan Fan
doaj   +1 more source

The Extended Bessel-Maitland Function and Integral Operators Associated with Fractional Calculus

open access: yesJournal of Mathematics, 2020
The aim of this paper is to introduce a presumably and remarkably altered integral operator involving the extended generalized Bessel-Maitland function. Particular properties are considered for the extended generalized Bessel-Maitland function connected ...
Kelelaw Tilahun   +2 more
doaj   +1 more source

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