Results 81 to 90 of about 73,328 (276)

Automated FRAP microscopy for high‐throughput analysis of protein dynamics in chromatin organization and transcription

FEBS Open Bio, EarlyView.
RoboMic is an automated confocal microscopy pipeline for high‐throughput functional imaging in living cells. Demonstrated with fluorescence recovery after photobleaching (FRAP), it integrates AI‐driven nuclear segmentation, ROI selection, bleaching, and analysis.
Selçuk Yavuz, Bart Geverts, Johan A. Slotman, Andrea Sacchetti, Stefan Prekovic, Martin E. van Royen, Adriaan B. Houtsmuller   +6 more
wiley   +1 more source

A comprehensive review of the Pachpatte-type inequality pertaining to fractional integral operators [PDF]

Surveys in Mathematics and its Applications
In the frame of fractional calculus, the term convexity is primarily utilized to address several challenges in both pure and applied research. The main focus and objective of this review paper is to present Pachpatte-type inequalities involving a variety
Muhammad Tariq, Asif Ali Shaikh, Sotiris K. Ntouyas   +2 more
doaj  

On Mikusinski's operators of fractional integration

, 1975
In the field F of convolution quotients,  b∝ is the operator of integration of fractional order ∝ and b∝ f   Is the Riemann - Liouville integral of order   ∝ of f. In this paper we give a generalization of this operator, which is denoted as b∝,va . Some particular cases are mentioned and the inverse operator is obtained.
Batting, A., Kalla, S. L.
openaire   +2 more sources

Quadruple integral equations and operators of fractional integration [PDF]

Glasgow Mathematical Journal, 1971
Cooke [1] modified a technique used by Erdelyi and Sneddon [2] to solve triple integral equations of a certain type. In this paper, we extend this method to solve the quadruple integral equationswhere F1, G2, F3 and G4 are prescribed functions of p and ψ(ξ) is to be determined. With no loss of generality we shall assume that G2(p)≡0, G4(p)≡0.
openaire   +2 more sources

dUTPase is essential in zebrafish development and possesses several single‐nucleotide variants with pronounced structural and functional consequences

FEBS Open Bio, EarlyView.
dUTPases are involved in balancing the appropriate nucleotide pools. We showed that dUTPase is essential for normal development in zebrafish. The different zebrafish genomes contain several single‐nucleotide variations (SNPs) of the dut gene. One of the dUTPase variants displayed drastically lower protein stability and catalytic efficiency as compared ...
Viktória Perey‐Simon, Angéla Békesi, Latifa Kazzazy, Jázmin Mihály, Máté Varga, Beáta G. Vértessy, Kinga Nyíri   +6 more
wiley   +1 more source

Fractional Calculus for Non-Discrete Signed Measures

Mathematics
In this paper, we suggest a first-ever construction of fractional integral and differential operators based on signed measures including a vector-valued case. The study focuses on constructing the fractional power of the Riemann–Stieltjes integral with a
Vassili N. Kolokoltsov, Elina L. Shishkina   +1 more
doaj   +1 more source

Differential regulation of ZFAS1 splice variants by endoplasmic reticulum stress in hepatocyte cell lines

FEBS Open Bio, EarlyView.
ZFAS1 is a lncRNA promoting cell proliferation and migration, exhibiting high expression in various cancers. It is conserved, widely expressed, and produces multiple splice variants with unclear roles. We identified several splice variants in hepatocyte models, and found that inhibiting or suppressing regulators of the unfolded protein response (PERK ...
Sébastien Soubeyrand, Paulina Lau, Ruth McPherson   +2 more
wiley   +1 more source

New Inequalities for GA–h Convex Functions via Generalized Fractional Integral Operators with Applications to Entropy and Mean Inequalities

Fractal and Fractional
We prove the inequalities of the weighted Hermite–Hadamard type the and Hermite–Hadamard–Mercer type for an extremely rich class of geometrically arithmetically-h-convex functions (GA-h-CFs) via generalized Hadamard–Fractional integral operators (HFIOs).
Asfand Fahad, Zammad Ali, Shigeru Furuichi, Saad Ihsan Butt, Ayesha, Yuanheng Wang   +5 more
doaj   +1 more source

A light‐triggered Time‐Resolved X‐ray Solution Scattering (TR‐XSS) workflow with application to protein conformational dynamics

FEBS Open Bio, EarlyView.
Time‐resolved X‐ray solution scattering captures how proteins change shape in real time under near‐native conditions. This article presents a practical workflow for light‐triggered TR‐XSS experiments, from data collection to structural refinement. Using a calcium‐transporting membrane protein as an example, the approach can be broadly applied to study ...
Fatemeh Sabzian‐Molaei, Fredrik Orädd, Konstantinos Magkakis, Magnus Andersson   +3 more
wiley   +1 more source

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source