Results 31 to 40 of about 3,859 (267)

Calpain small subunit homodimerization is robust and calcium‐independent

FEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy, Trina Dykstra‐MacPherson, Mathias A. Bell, Peter L. Davies, Ruby May A. Sullan   +4 more
wiley   +1 more source

New Approaches to Fractal–Fractional Bullen’s Inequalities Through Generalized Convexity

Fractal and Fractional
This paper introduces a new identity involving fractal–fractional integrals, which allow us to derive several new Bullen-type inequalities via generalized convexity.
Wedad Saleh, Hamid Boulares, Abdelkader Moumen, Hussien Albala, Badreddine Meftah   +4 more
doaj   +1 more source

On generalized fractional integral inequalities for the monotone weighted Chebyshev functionals

Advances in Difference Equations, 2020
In this paper, we establish the generalized Riemann–Liouville (RL) fractional integrals in the sense of another increasing, positive, monotone, and measurable function Ψ.
Gauhar Rahman, Kottakkaran Sooppy Nisar, Behzad Ghanbari, Thabet Abdeljawad   +3 more
doaj   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

On generalized stochastic fractional integrals and related inequalities

Modern Stochastics: Theory and Applications, 2018
The generalized mean-square fractional integrals ${\mathcal{J}_{\rho ,\lambda ,u+;\omega }^{\sigma }}$ and ${\mathcal{J}_{\rho ,\lambda ,v-;\omega }^{\sigma }}$ of the stochastic process X are introduced.
Hüseyin Budak, Mehmet Zeki Sarikaya
doaj   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

An isoform of 14‐3‐3 protein regulates transbilayer lipid movement at the plasma membrane

FEBS Letters, EarlyView.
Loss of 14‐3‐3ζ in CHO cells confers resistance to exogenous phosphatidylserine (PS) and impairs endocytosis‐independent inward flip‐flop of fluorescent PS at the plasma membrane. RNAi‐mediated knockdown reproduces this defect, while no additive effect is seen in ATP11C‐deficient cells.
Akiko Yamaji‐Hasegawa, Akira Hattori, Masafumi Tsujimoto, Toshihide Kobayashi   +3 more
wiley   +1 more source

Newton-type Inequalities for Fractional Integrals by Various Function Classes

Universal Journal of Mathematics and Applications
The authors of the paper examine some Newton-type inequalities for various function classes using Riemann-Liouville fractional integrals. Namely, we establish some Newton-type inequalities for bounded functions by fractional integrals.
Hüseyin Budak, Tingsong Du, Fatih Hezenci   +2 more
doaj   +1 more source

Epigenetic blind spots – the role of DNA methylation dynamics in stem cell‐based models of embryogenesis

FEBS Letters, EarlyView.
Embryo‐like structures (stembryos) are an innovative tool, but they are hindered by experimental variability and limited developmental potential. DNA methylation is crucial for mammalian development, but its status in stembryo models is poorly characterized.
Sara Canil, Anna Corrà, Annalisa Scapolatiello, Chengxiang Qiu, Gianluca Amadei   +4 more
wiley   +1 more source

Midpoint-type inequalities via twice-differentiable functions on tempered fractional integrals

Journal of Inequalities and Applications, 2023
In this paper, we obtain an equality involving tempered fractional integrals for twice-differentiable functions. By using this equality, we establish several left Hermite–Hadamard-type inequalities for the case of tempered fractional integrals. Moreover,
Fatih Hezenci, Hüseyin Budak
doaj   +1 more source