Results 51 to 60 of about 1,483,605 (294)
Molecular Oncology, EarlyView.This study identifies ARHGAP5, in addition to the frequently mutated ARHGAP35, as significantly mutated in endometrial cancer. Mutations in both genes co‐occur and are associated with their correlated downregulation. Functional CRISPR studies show that both paralogs regulate similar pathways, including actin cytoskeleton organization.
Mathilde Pinault +12 more
wiley +1 more source
Fractional CO2 Laser Resurfacing Complications [PDF]
Seminars in Plastic Surgery, 2012 Fractionated CO2 laser technology has allowed physicians to resurface patients with a lower rate of complications than nonfractionated ablative laser treatment. Unfortunately, adverse effects can still occur even with the best technology and physician care. Complication prevention, detection, and treatment are an important part of a physician's ability
openaire +2 more sources
, 2019 Background: Melasma is an acquired hyperpigmentation of the skin that mostly affects areas exposed to the sun. The treatment of melasma can be challenging as it is prone to relapse.
Aksoy, B. +11 more
core +1 more source
Mutant p53R273H disrupts PDPK1 homodimerization and contributes to PDPK1 activation
Molecular Oncology, EarlyView.How mutant p53R273H drives AKT signaling is unclear. We show that p53R273H, but not wild‐type, directly binds PDPK1 via a mutation‐dependent conformational change. This interaction disrupts inhibitory PDPK1 homodimerization and enhances AKT phosphorylation.
Mei Chee Lim +11 more
wiley +1 more source
Effect of Topical 0.5% Timolol Maleate After Fractional Carbon Dioxide Laser Versus Carbon Dioxide Laser Alone In Treatment Acne Scars [PDF]
Zagazig University Medical JournalBackground: Commonly affecting the face, chest, and back, acne is an inflammatory disorder that can be treated with a variety of modalities, with laser treatment remaining a key option for scar treatment.
Ayman Ahmed Youssef +2 more
doaj +1 more source
Spatial heterogeneity of hotspot mutations and clonal relatedness in ovarian endometrioid carcinoma
Molecular Oncology, EarlyView.Spatially resolved analysis revealed heterogeneous distributions of selected cancer‐associated mutations within ovarian endometrioid carcinomas. Shared mutations between paired endometrial and ovarian tumors supported clonal relatedness. These findings highlight the value of sampling multiple tumor regions when interpreting molecular profiles ...
Takahito Ashihara +10 more
wiley +1 more source
FEBS Open Bio, EarlyView.RoboMic is an automated confocal microscopy pipeline for high‐throughput functional imaging in living cells. Demonstrated with fluorescence recovery after photobleaching (FRAP), it integrates AI‐driven nuclear segmentation, ROI selection, bleaching, and analysis.
Selçuk Yavuz +6 more
wiley +1 more source
Fractional Carbon Dioxide Laser Resurfacing [PDF]
Seminars in Plastic Surgery, 2012 Currently available ablative fractional CO2 lasers provide excellent results and diminish down time with fewer complications than previous generation CO2 lasers. Mechanisms of action, treatment parameters, as well as pre- and postoperative care will be discussed.
openaire +2 more sources
, 2021 Integral equations and inequalities have an important place in time scales and harmonic analysis. The norm of integral operators is one of the important study topics in harmonic analysis.
Akın, Lütfi
core
Single‐molecule DNA flow‐stretch assays for high‐throughput DNA–protein interaction studies
FEBS Open Bio, EarlyView.We describe an optimised single‐molecule DNA flow‐stretch assay that visualises DNA–protein interactions in real time. Linear DNA fragments are tethered to a surface and stretched by buffer flow for fluorescence imaging. Using λ and φX174 DNA, this protocol enhances reproducibility and accessibility, providing a versatile approach for studying diverse ...
Ayush Kumar Ganguli +8 more
wiley +1 more source