Results 51 to 60 of about 14,195,801 (251)

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

A Caputo (discretization) fractional-order model of glucose-insulin interaction: numerical solution and comparisons with experimental data

Journal of Taibah University for Science, 2021
In this paper, we investigate a (discretization) Caputo fractional glucose-insulin model qualitatively with incommensurate orders that appear in Bergman's minimal model.
Mansoor H. Alshehri, Faisal Z. Duraihem, Ahmad Alalyani, Sayed Saber   +3 more
doaj   +1 more source

Identification of a Shiga toxin A‐derived peptide internalized into Gb3 receptor‐bearing cells via interaction with the Shiga toxin B subunit

FEBS Letters, EarlyView.
The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi, João C. Encarnação, Valeria Napolitano, Grzegorz Dubin, Grzegorz Popowicz, Karl Andersson, U. Helena Danielson   +6 more
wiley   +1 more source

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source

Характеристики деформационного процесса в зоне субдукции Курило-Камчатской островной дуги в фазе афтершоков на основе дробной модели деформационной активности

Vestnik KRAUNC: Fiziko-Matematičeskie Nauki
В статье представлены результаты расчётов значений параметров, определяющих свойства деформационного процесса, на основании данных каталога землетрясений Камчатского филиала ФГБУН Федеральный исследовательский центр «Единая геофизическая служба РАН» (КФ ...
Шереметьева, О.В., Шевцов, Б.М.   +1 more
doaj   +1 more source

Development of Fractional Order Modeling of Voltage Source Converters

IEEE Access, 2020
This paper proposes a mathematical fractional order modelling of Voltage Source Converters (VSC). Fractional behaviour helps to model and describe a real object more accurately than the integer order model.
Monika Sharma, Bharat Singh Rajpurohit, Samar Agnihotri, Akshay Kumar Rathore   +3 more
doaj   +1 more source

Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions

FEBS Letters, EarlyView.
The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang, Hyo Been Jin, Chang Min Kim, So Yeon Lee, Hyun Ho Park   +4 more
wiley   +1 more source

Приложение дробной модели деформационной активности к исследованию свойств эредитарности и нестационарности сейсмического процесса в зоне субдукции Курило-Камчатской островной дуги в фазе релаксации

Vestnik KRAUNC: Fiziko-Matematičeskie Nauki
Исследование свойств эредитарности и нестационарности сейсмического процесса в фазе релаксации проводится на основании данных каталога землетрясений КФ ЕГС РАН (01.01.1962 − 31.12.2002, зона субдукции Курило-Камчатской островной дуги).
Шереметьева, О.В., Шевцов, Б.М.   +1 more
doaj   +1 more source

Research on Population Development Trend in Huizhou of China Forecast Based on Optimal Weighted Combination Method and Fractional Grey Model

Journal of Mathematics, 2021
In this paper, the optimal weighted combination model and fractional grey model are constructed. The coefficients of the optimal weighted combination model are determined by minimizing the sum of squares of resists of each model.
Dewang Li, Jianbao Chen, Meilan Qiu
doaj   +1 more source

Optimal control of fractional systems: a diffusive formulation [PDF]

, 2010
Optimal control of fractional linear systems on a finite horizon can be classically formulated using the adjoint system. But the adjoint of a causal fractional integral or derivative operator happens to be an anti-causal operator: hence, the adjoint ...
Matignon, Denis
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