Results 61 to 70 of about 14,195,801 (251)

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

Предвестники землетрясений в теории критичности геодеформаций

Vestnik KRAUNC: Fiziko-Matematičeskie Nauki
Предвестники землетрясений рассматриваются как резонансные проявления критических геодеформаций, дислокационные изменения которых отвечают за аномальные свойства, как самих деформаций, так и порожденных ими физических процессов, играющих роль индикаторов
Шевцов, Б.М., Шереметьева, О.В.   +1 more
doaj   +1 more source

Fractal Dynamics and Control of the Fractional Potts Model on Diamond-Like Hierarchical Lattices

Discrete Dynamics in Nature and Society, 2020
The fractional Potts model on diamond-like hierarchical lattices is introduced in this manuscript, which is a fractional rational system in the complex plane. Then, the fractal dynamics of this model is discussed from the fractal viewpoint.
Weihua Sun, Shutang Liu
doaj   +1 more source

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network

FEBS Letters, EarlyView.
Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley   +1 more source

A Fractional Optimal Control Model with Multi-Degree of Freedom for a Simple Cash Balance Problem

Mathematics
This study introduces a fractional optimal control model for managing cash balances, emphasizing the critical factor of long-term memory, particularly in the context of multiple investments.
Zhanmei Lv, Yi Chen
doaj   +1 more source

Analysis and Modeling of Fractional-Order Buck Converter Based on Riemann-Liouville Derivative

IEEE Access, 2019
In previous studies, researchers used the fractional definition of Caputo to study fractional-order power converter. However, it is found that the model based on Caputo fractional definition is inconsistent with the actual situation.
Zhihao Wei, Bo Zhang, Yanwei Jiang
doaj   +1 more source

Fractional location problems [PDF]

In this paper we analyze some variants of the classical uncapacitated facility location problem with a ratio as an objective function. Using basic concepts and results of fractional programming, we identify a class of one-level fractional location ...
Frenk, J.B.G., Gromicho, J.A.S., Barros, A.I.   +2 more
core  

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

FEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante, Robert Sharp, Pradip K. Saha, Elizabeth S. Anaya, Elizabeth L. Lieu, Evelyn L. de Groot, Pooja Patel, Mi Jeong Heo, Aaron R. Cox, Kang Ho Kim, Sean M. Hartig   +10 more
wiley   +1 more source

Analysis of Drude model using fractional derivatives without singular kernels

Open Physics, 2017
We report study exploring the fractional Drude model in the time domain, using fractional derivatives without singular kernels, Caputo-Fabrizio (CF), and fractional derivatives with a stretched Mittag-Leffler function.
Jiménez Leonardo Martínez, García J. Juan Rosales, Contreras Abraham Ortega, Baleanu Dumitru   +3 more
doaj   +1 more source