Results 81 to 90 of about 652,382 (290)
FEBS Letters, EarlyView.How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley +1 more source
FRACTIONAL MOMENTS OF THE RIEMANN ZETA-FUNCTION, II
The Quarterly Journal of Mathematics, 1993 It is conjectured that for any real \(k \geq 0\) there exists a constant \(C_ k\) such that \[ I_ k(T) = \int^ T_ 0 \left | \zeta \left( {1 \over 2} + it \right) \right |^{2k} dt \sim C_ k T(\log T)^{k^ 2}. \] It is known that \(C_ 0=1\), \(C_ 1=1\) and \(C_ 2 = 1/2 \pi^ 2\), but it is not clear what \(C_ k\) should be in the general case. Assuming the
openaire +2 more sources
Ergodicity of hypoeliptic SDEs driven by fractional Brownian motion [PDF]
, 2009 We demonstrate that stochastic differential equations (SDEs) driven by fractional Brownian motion with Hurst parameter H > 1/2 have similar ergodic properties as SDEs driven by standard Brownian motion.
Hairer, Martin, Pillai, Natesh S.
core
Recognition of 3D Images by Fusing Fractional-Order Chebyshev Moments and Deep Neural Networks
SensorsIn order to achieve efficient recognition of 3D images and reduce the complexity of network parameters, we proposed a novel 3D image recognition method combining deep neural networks with fractional-order Chebyshev moments.
Lin Gao +3 more
doaj +1 more source
FEBS Letters, EarlyView.Synechocystis strains deficient in succinate dehydrogenase (SDH) secrete more succinate than the WT under dark anaerobic conditions, supporting that SDH then primarily acts as SDH, not as a fumarate reductase. L‐aspartate oxidase (Laspo) from Synechocystis is functional under anaerobic conditions, reducing fumarate to succinate.
Kateryna Kukil +3 more
wiley +1 more source
The Periodogram of fractional processes. [PDF]
We analyse asymptotic properties of the discrete Fourier transform and the periodogram of time series obtained through (truncated) linear filtering of stationary processes.
Velasco, Carlos
core
Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
wiley +1 more source
Molecular Oncology, EarlyView.Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura +19 more
wiley +1 more source
Dynamics of Subordinate Fractional Diffusion Moments on Curved Surfaces at Short Times
DynamicsDiffusion on curved surfaces deviates from the flat case due to geometrical corrections in the evolution of its moments, such as the geodesic mean square displacement.
Guillermo Chacón-Acosta +1 more
doaj +1 more source
Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining
Molecular Oncology, EarlyView.IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis +3 more
wiley +1 more source