Results 71 to 80 of about 5,262 (258)

Recognition of 3D Images by Fusing Fractional-Order Chebyshev Moments and Deep Neural Networks

open access: yesSensors
In order to achieve efficient recognition of 3D images and reduce the complexity of network parameters, we proposed a novel 3D image recognition method combining deep neural networks with fractional-order Chebyshev moments.
Lin Gao   +3 more
doaj   +1 more source

Odd moments and adding fractions

open access: yesProceedings of the London Mathematical Society
AbstractWe prove near‐optimal upper bounds for the odd moments of the distribution of coprime residues in short intervals, confirming a conjecture of Montgomery and Vaughan. As an application, we prove near‐optimal upper bounds for the average of the refined singular series in the Hardy–Littlewood conjectures concerning the number of prime ‐tuples for
Thomas F. Bloom, Vivian Kuperberg
openaire   +4 more sources

Reconstructing enzyme evolution by protein engineering

open access: yesFEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler   +2 more
wiley   +1 more source

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

open access: yesMolecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano   +6 more
wiley   +1 more source

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

open access: yesMolecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson   +9 more
wiley   +1 more source

Dynamics of Subordinate Fractional Diffusion Moments on Curved Surfaces at Short Times

open access: yesDynamics
Diffusion on curved surfaces deviates from the flat case due to geometrical corrections in the evolution of its moments, such as the geodesic mean square displacement.
Guillermo Chacón-Acosta   +1 more
doaj   +1 more source

ENTRAINMENT FACTOR OF INDIVIDUAL GLITCH FRACTIONAL MOMENT OF INERTIA

open access: yesRevista Mexicana de Astronomía y Astrofísica, 2019
The superfluid in the inner crust of a neutron star is assumed to be the reservoir of momentum released in a pulsar glitch. Recently, due to crustal entrainment, it appears debatable whether the magnitude of the inner crust is sufficient to contain the superfluid responsible for large glitches.
Eya, Innocent O.   +2 more
openaire   +2 more sources

Pre‐analytical optimization of cell‐free DNA and extracellular vesicle‐derived DNA for mutation detection in liquid biopsies

open access: yesMolecular Oncology, EarlyView.
Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen   +11 more
wiley   +1 more source

EDNRB‐dependent endothelin signaling reduces proliferation and promotes proneural‐to‐mesenchymal transition in gliomas

open access: yesMolecular Oncology, EarlyView.
Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau   +36 more
wiley   +1 more source

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

open access: yesMolecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch   +13 more
wiley   +1 more source

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