Results 71 to 80 of about 10,348 (263)
Molecular Oncology, EarlyView.Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim +3 more
wiley +1 more source
Molecular Oncology, EarlyView.Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller +10 more
wiley +1 more source
Molecular Oncology, EarlyView.LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang +9 more
wiley +1 more source
On Fractional Symmetric Hahn Calculus
Mathematics, 2019 In this paper, we study fractional symmetric Hahn difference calculus. The new idea of the symmetric Hahn difference operator, the fractional symmetric Hahn integral, and the fractional symmetric Hahn operators of Riemann−Liouville and Caputo types
Nichaphat Patanarapeelert +1 more
doaj +1 more source
Molecular Oncology, EarlyView.Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley +1 more source
Spectral properties of fractional differentiation operators
Electronic Journal of Differential Equations, 2018 We consider the fractional differentiation operators in a variety of senses. We show that the strong accretive property is the common property of fractional differentiation operators.
Maksim V. Kukushkin
doaj
Molecular Oncology, EarlyView.The cell‐autonomous roles of interferon type 1 vary based on duration and intensity. While acute, robust signaling results in cancer cell cytotoxic effects, sustained, low‐level signaling is associated with tumor‐promoting effects. This review summarizes current research of IFN‐1 in cancer and within the clinical setting, with an emphasis on female ...
Ashlyn Conant +7 more
wiley +1 more source
Fractional operators and applications to fractional martingal
International Journal of Advances in Applied Mathematics and Mechanics, 2018 Summary: In this paper, we use the fractional operators for to give the fractional martingale properties. We give again some examples.
openaire +2 more sources
On a certain fractional operator
Proceedings of the Japan Academy, Series A, Mathematical Sciences, 1991 Let \(S:*(\alpha),\;K(\alpha)\) be the class of starlike and convex functions of order \(\alpha\), analytic in the open unit disk. Define the convolution of \(f_ 1 * f_ 2 (z)=\sum:\infty_{n=0} a_{1,n+1}a_{2,n+1}z:{n+1},\;f_ i (z)= \sum:{\infty}_{n=0}a_{i,n+1}z:{n+1},\;i=1,\;2.\) Let \((\lambda)_ n\) be the Pochhammer symbol defined by \((\lambda)_ 0=1,\
Owa, Shigeyoshi +2 more
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Molecular Oncology, EarlyView.Tumour heterogeneity and clonal evolution of metastatic salivary gland cancer were evaluated in two patients with adenoid carcinoma and one patient with myoepithelial carcinoma. Radiology‐guided autopsy enabled multi‐region sampling (total samples n = 149), followed by whole‐genome sequencing and phylogenetic reconstruction (17 tumour samples, 4–7 per ...
Gerben Lassche +10 more
wiley +1 more source