Results 61 to 70 of about 375,371 (287)

Calpain small subunit homodimerization is robust and calcium‐independent

FEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy, Trina Dykstra‐MacPherson, Mathias A. Bell, Peter L. Davies, Ruby May A. Sullan   +4 more
wiley   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

An isoform of 14‐3‐3 protein regulates transbilayer lipid movement at the plasma membrane

FEBS Letters, EarlyView.
Loss of 14‐3‐3ζ in CHO cells confers resistance to exogenous phosphatidylserine (PS) and impairs endocytosis‐independent inward flip‐flop of fluorescent PS at the plasma membrane. RNAi‐mediated knockdown reproduces this defect, while no additive effect is seen in ATP11C‐deficient cells.
Akiko Yamaji‐Hasegawa, Akira Hattori, Masafumi Tsujimoto, Toshihide Kobayashi   +3 more
wiley   +1 more source

Performance Assessment of FO-PID Temperature Control System Using a Fractional Order LQG Benchmark

IEEE Access, 2020
In this paper, a fractional order LQG benchmark is proposed for the control performance assessment of fractional order control systems. Similar to the conventional LQG benchmark, the fractional order LQG performance benchmark curve is determined by the ...
Rongxuan Li, Feng Wu, Pingzhi Hou, Hongbo Zou   +3 more
doaj   +1 more source

Time-fractional diffusion of distributed order

, 2007
The partial differential equation of Gaussian diffusion is generalized by using the time-fractional derivative of distributed order between 0 and 1, in both the Riemann-Liouville (R-L) and the Caputo (C) sense.
Gorenflo, Rudolf, Mainardi, Francesco, Mura, Antonio, Pagnini, Gianni   +3 more
core   +3 more sources

Organizing the interface—Plasma membrane architecture and receptor dynamics in virus‐cell interactions

FEBS Letters, EarlyView.
Plasma membranes contain dynamic nanoscale domains that organize lipids and receptors. Because viruses operate at similar scales, this architecture shapes early infection steps, including attachment, receptor engagement, and entry. Using influenza A virus and HIV‐1 as examples, we highlight how receptor nanoclusters, multivalent glycan interactions ...
Jan Schlegel, Christian Sieben
wiley   +1 more source

A novel state–space model reference adaptive speed control design for fractional-order model-based wind turbine

International Journal of Electrical Power & Energy Systems
Fractional-order adaptive control has recently emerged as an effective solution for controlling processes whose model is unknown or varies slowly over time.
Mohammed Islam Leulmi, Samir Ladaci, Horst Schulte   +2 more
doaj   +1 more source

Phenotypic and genotypic characterization of single circulating tumor cells in the follow‐up of high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Single circulating tumor cells (sCTCs) from high‐grade serous ovarian cancer patients were enriched, imaged, and genomically profiled using WGA and NGS at different time points during treatment. sCTCs revealed enrichment of alterations in Chromosomes 2, 7, and 12 as well as persistent or emerging oncogenic CNAs, supporting sCTC identity.
Carolin Salmon, Rui P. L. Neves, Nikolas H. Stoecklein, Sven‐Thorsten Liffers, Jens Siveke, Jan D. Kuhlmann, Pauline Wimberger, Paul Buderath, Rainer Kimmig, Sabine Kasimir‐Bauer   +9 more
wiley   +1 more source

Time-Fractional Optimal Control of Initial Value Problems on Time Scales

, 2019
We investigate Optimal Control Problems (OCP) for fractional systems involving fractional-time derivatives on time scales. The fractional-time derivatives and integrals are considered, on time scales, in the Riemann--Liouville sense.
A Ahmadkhanlu, A Cabada, AB Malinowska, B Bayour, Benaoumeur Bayour, Benaoumeur Bayour, D Baleanu, D Baleanu, D Idczak, D Mozyrska, E Hernández, EG Bajlekova, ER Nwaeze, G Mophou, GM Bahaa, GM Mophou, GSF Frederico, GSF Frederico, I Podlubny, K Mekhalfi, L Bourdin, M Bohner, M Bohner, MC Caputo, Monika Dryl, Moulay Rchid Sidi Ammi, Moulay Rchid Sidi Ammi, N Benkhettou, N Benkhettou, N Benkhettou, N Benkhettou, N Özdemir, NRO Bastos, NRO Bastos, NRO Bastos, O Lavrova, OP Agrawal, OP Agrawal, R Almeida, RP Agarwal, RP Agarwal, S Abbas, T Abdeljawad, Thabet Abdeljawad   +43 more
core   +1 more source

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source