Results 101 to 110 of about 119 (117)

Endophytic fungi from two isolated Bethencourtia palmensis populations: metabolomic and bioactivity fingerprinting

Pest Management Science, EarlyView.
We compared two island populations of Bethencourtia palmensis and their culturable endophytic fungi, revealing distinct plant chemistries and a higher biopesticidal potential in the endophytic fungi from La Palma population along with high potential for the discovery of novel compounds.
Jorge Rojas López‐Menchero, Juan Imperial, Carmen Elisa Díaz, María Fe Andrés, Azucena González‐Coloma   +4 more
wiley   +1 more source

Disease–Drug–Drug Interaction of Imatinib in COVID‐19 ARDS: A Pooled Population Pharmacokinetic Analysis

CPT: Pharmacometrics &Systems Pharmacology, Volume 14, Issue 3, Page 583-595, March 2025.
ABSTRACT Prior pharmacokinetic (PK) analysis revealed that increased alpha‐1‐acid glycoprotein (AAG) levels are associated with decreased imatinib unbound fraction in coronavirus disease 2019 (COVID‐19) patients. This study aimed to investigate the PK of total and unbound concentrations of imatinib and the metabolite N‐desmethyl imatinib in ...
Medhat M. Said, Job R. Schippers, Leila Atmowihardjo, Yingxue Li, Mick S. van der Plas, Harm J. Bogaard, Lieuwe D. J. Bos, Ron A. A. Mathôt, Jurjan Aman, Eleonora L. Swart, Imke H. Bartelink   +10 more
wiley   +1 more source

Flavonoids From Sophora tonkinensis Disrupt STING‐TBK1‐IRF3 Complex Assembly and Ameliorate Inflammatory Diseases by Modulating cGAS‐STING Signaling

Phytotherapy Research, EarlyView.
STF attenuates the activation of the cGAS‐STING pathway by blocking the interactions between STING and IRF3 as well as between STING and TBK1, thereby exerting therapeutic effects against inflammatory diseases. ABSTRACT cGAS‐STING pathway is a core regulator of innate immunity and inflammatory responses. Aberrant activation of the cGAS‐STING pathway is
Jincai Wen, Yuanyuan Guo, Yingjie Xu, Guirong Zhang, Xianling Wang, Sida Song, Jinming Liu, Yijin Liu, Qiaodi Liu, Yi Hao, Xiaoyan Zhan, Xiaohe Xiao, Zhaofang Bai   +12 more
wiley   +1 more source

Gentiopicroside Regulates EGFR and Induces Its Lysosomal Degradation to Attenuate Heart Failure

Phytotherapy Research, EarlyView.
GPS attenuates pressure overload‐induced cardiac remodeling by promoting lysosomal degradation of EGFR. TAC‐induced EGFR accumulation activates AKT/ERK1/2 signaling and drives pathological cardiac hypertrophy, fibrosis, apoptosis, oxidative stress, and cardiac dysfunction. GPS promotes lysosome‐dependent EGFR degradation, thereby limiting excessive AKT/
Mingzhen Cao, Da Ke, Jian Ni, Yuan Yuan, Zhang Nan, Xiujun Dai, Heng Zhou   +6 more
wiley   +1 more source

Neohesperidin Alleviates Ferroptosis in Doxorubicin‐Induced Cardiotoxicity via Mettl3‐m6A‐Nrf2 Signaling

Phytotherapy Research, EarlyView.
Neohesperidin alleviates doxorubicin‐induced cardiotoxicity by inhibiting METTL3‐mediated m6A modification of Nrf2 mRNA, thereby regulating Nrf2 and suppressing ferroptosis. ABSTRACT Doxorubicin (DOX) has antitumor efficacy, but its clinical application is restricted by multiple side effects, especially cardiotoxicity.
Ruijia Wen, Xin Dong, Haowen Zhuang, Yusheng Huang, Mengyuan Wang, Zhongzheng Zhang, Jinhong Chen, Wei Wang, Chun Li, Junyan Wang   +9 more
wiley   +1 more source

Identification of Active Compounds of Centipeda minima for Potentiating Tumor Immunotherapy in Non‐Small Cell Lung Cancer via FANCD2‐cGAS/STING/IFN‐I Signaling Axis

Phytotherapy Research, EarlyView.
Schematic diagram illustrating the underlying mechanisms by which ECM and its active components activate the FANCD2‐cGAS/STING/IFN‐I signaling axis, thus enhancing the therapeutic efficacy of anti‐PD‐1 in NSCLC. ABSTRACT Activation of cGAS/STING/IFN‐I signaling pathway serves as a potential therapeutic strategy to enhance CD8+ T cells infiltration and ...
Han‐Chen Wang, Chu‐Ying Chen, Jiang‐Tao Xiao, Rou‐Qiao Zheng, Wen‐Da He, Zi‐Wei Xu, Su‐Fen Wei, Tao Su, Guang‐Biao Zhou, Yong‐Qiang Liu   +9 more
wiley   +1 more source

Stratospheric influence on tropical cyclone evolution

Quarterly Journal of the Royal Meteorological Society, EarlyView.
We developed a metric based on moist static energy to detect and quantify the intrusion of stratospheric air into the inner core of tropical cyclones. High‐resolution numerical simulations show that this stratospheric interaction forms warm anomalies (high‐level warm cores) in the upper troposphere.
Andrea Davin, Giousef Alexandros Charinti, Caroline Muller, Andrea Polesello, Claudia Pasquero   +4 more
wiley   +1 more source

Fractional Newton Mechanics With Conformable Fractional Derivative

Journal of Computational and Applied Mathematics, 2015
Won Sang Chung
exaly  

Crank–Nicolson Method for the Fractional Diffusion Equation With the Riesz Fractional Derivative

Journal of Computational Physics, 2012
Cem Çelik, Melda Duman
exaly  

Recent History of Fractional Calculus

Communications in Nonlinear Science and Numerical Simulation, 2011
Virginia S. Kiryakova, Francesco Mainardi, J Tenreiro Machado   +2 more
exaly