Results 71 to 80 of about 41,489 (237)

PFKFB4 Deubiquitination by USP10 Enhances Fumarate Metabolism to Orchestrate the KDM1A/Rad51 Axis and Confer Radioresistance in Lung Cancer

Advanced Science, EarlyView.
USP10 binds to and stabilizes PFKFB4, enhancing glycolytic ATP production, which activates the urea cycle and elevates fumarate. This inhibits histone demethylase KDM1A, leading to increased H3K4me1 enrichment at the Rad51 promoter and direct activation of Rad51 transcription, which confers lung cancer radioresistance. The PFKFB4 inhibitor 5MPN targets
Yunshang Chen, Zilong Wu, Yongqiang Yang, Ruoxin Fang, Huichan Xue, Rui Zhou, Gang Wu, Xiaohua Jie   +7 more
wiley   +1 more source

Multiple solutions for the fractional differential equation with concave-convex nonlinearities and sign-changing weight functions

Advances in Difference Equations, 2017
In this paper, by using the fibering map and the Nehari manifold, we prove the existence and multiple results of solutions for the following fractional differential equation: { D T α t ( 0 D t α u ) = λ h ( t ) | u | p − 2 u + b ( t ) | u | q − 2 u , t ∈
Hai Pu, Lili Cao
doaj   +1 more source

Bound Water as a Reinforcing Element for Ultra‐Strong Polyacrylamide

Advanced Science, EarlyView.
Rather than acting as a conventional plasticizer, bound water serves as a reinforcing element in polyacrylamide by constructing strong PAM–water–PAM hydrogen‐bond networks. This water‐mediated architecture delivers ultra‐high mechanical strength and exceptional flame resistance, redefining the role of water in polymer reinforcement.
Sirawit Pruksawan, Nannan Li, Zehuang Lin, Jianwei Zheng, Terence Jun En Loh, Yi Ting Chong, Junhua Kong, Xunan Hou, Xian Jun Loh, Chaobin He, FuKe Wang   +10 more
wiley   +1 more source

Lyapunov type inequalities for the Riemann-Liouville fractional differential equations of higher order

Advances in Difference Equations, 2017
In this paper, some new Lyapunov type inequalities will be presented for Riemann-Liouville fractional differential equations of the form ( D a α x ) ( t ) + p ( t ) | x ( t ) | μ − 1 x ( t ) + q ( t ) | x ( t ) | γ − 1 ( t ) x ( t ) = f ( t ) , $$\bigl(D^
Laihui Zhang, Zhaowen Zheng
doaj   +1 more source

Deltacoronavirus Modulates circRNA cGLIS3 Metabolism to Evade Host Antiviral Response

Advanced Science, EarlyView.
This study reveals that both deltacoronavirus nucleocapsid protein and host RNA binding protein IGF2BP2 promote circular RNA GLIS3 (cGLIS3) biogenesis by binding to GLIS3 pre‐mRNA. The m6A modification‐mediated cGLIS3‐IGF2BP2 interaction weakens RNase L‐mediated degradation of cGLIS3 while facilitates a ubiquitin‐dependent degradation of IGF2BP2, thus ...
Liuyang Du, Liping Wang, Sujing Diao, Juan Li, Lei Zhao, Yan Yan, Haimin Li, Weiren Dong, Wei Wu, Jinyan Gu, Jiyong Zhou   +10 more
wiley   +1 more source

Multiple normalized solutions for fractional (p,q)-Laplacian equations

Electronic Journal of Differential Equations
In this article, we consider the multiplicity results of normalized solutions of the fractional $(p,q)$-Laplacian equation $$\displaylines{ (-\Delta)_p^{s} u+(-\Delta)_q^{s} u=\lambda |u|^{p-2}u+h(\varepsilon x)f(u)+g(u) \quad\text{in }\mathbb{R}^N,\cr ...
Lihong Bao, Libo Wang, Min Li
doaj  

Generalized quasi-linear fractional Wentzell problems

Advances in Nonlinear Analysis
Given a bounded (ε,δ)\left(\varepsilon ,\delta )-domain Ω⊆RN\Omega \subseteq {{\mathbb{R}}}^{N} (N≥2N\ge 2) whose boundary Γ≔∂Ω\Gamma := \partial \Omega is a dd-set for d∈(N−p,N)d\in \left(N-p,N), we investigate a generalized quasi-linear elliptic ...
Mesino-Espinosa Efren, Vélez-Santiago Alejandro   +1 more
doaj   +1 more source

Qualitative properties of solutions to generalized eigenvalue problems [PDF]

Arab Journal of Mathematical Sciences
PurposeThis paper investigates the qualitative properties of solutions to a fractional (p,)-Laplace eigenvalue problem with nonhomogeneous terms.
Abdelhamid Gouasmia, Oumaima Ouennas, Amel Bekhouche   +2 more
doaj   +1 more source

Nanoscale Confinement Enhances Ultrafast Demagnetization

Advanced Science, EarlyView.
Next generation spintronics may depend on successfully combining femtosecond spin dynamics with nanoscale device miniaturization. We address this by systematically studying the effect of nanoscale confinement on the femtosecond demagnetization of Iron. By combining ultrafast experiments sensitive to spins, charge carriers, and phonons, we uncover a nm ...
Yoav William Windsor, Tobias Lojewski, Moumita Kundu, Klaus Sokolowski‐Tinten, Nico Rothenbach, Andrea Eschenlohr, Markus Ernst Gruner, Katharina Ollefs, Carolin Schmitz‐Antoniak, Soma Salamon, Daniela Zahn, Laurenz Rettig, Christian Schüßler‐Langeheine, Niko Pontius, Renkai Li, Mianzhen Mo, Suji Park, Xiaoshe Shen, Stephen Weathersby, Xijie Wang, Rossitza Pentcheva, Heiko Wende, Ulrich Nowak, Uwe Bovensiepen   +23 more
wiley   +1 more source

SR‐A3 Promotes USP18‐Mediated deISGylation of STING to Protect Against Myocardial Ischemia‐Reperfusion Injury

Advanced Science, EarlyView.
MI/RI is a major clinical challenge with high morbidity and mortality. This study demonstrates that SR‐A3 expression is downregulated in MI/RI, and its deletion exacerbates damage via the USP18/ISG15/STING axis, revealing SR‐A3 as a potential therapeutic target.
Yufei Han, Guolin Miao, Yinqi Zhao, Zhiyong Du, Kaikai Lu, Changqi Xiao, Aiden Xian, Jiaxin Duanmu, Zihao Zhou, Jinxuan Chen, Lianxin Zhang, Chao Zhai, Yitong Xu, Zhaoling Li, Xianqin Shen, Sijing Shi, Jingxuan Chen, Si Mei, Yuan Fang, Liwen Zheng, Ling Zhang, Yuhui Wang, Wei Huang, Erdan Dong, Xunde Xian   +24 more
wiley   +1 more source