Results 151 to 160 of about 778,497 (306)

Single-Stage Hybrid Fixation of a Grade III Open, Unstable Trimalleolar Ankle Fracture with Syndesmotic Disruption and Posterior Talar Subluxation

Introduction: Trimalleolar ankle fractures, which involve syndesmotic damage and talar subluxation, are serious injuries that are complicated by open wounds.
Shailesh Kumar, Naveen Kumar Duraisamy, C S Likhit, D Sudharsan, K Purushothaman, Jeff Walter Rajadurai OR   +5 more
core   +1 more source

An Interpretable, Data‐Driven, Hierarchical Multi‐Domain Fusion Framework for Classification and Motor Function Scoring in Chronic Ankle Instability

Advanced Science, EarlyView.
An AI‐enabled digital twin framework integrates wearable EMG sensing with hierarchical multi‐domain fusion to classify chronic ankle instability, distinguish clinically relevant subtypes, and generate continuous motor function scores. Clinically interpretable functional stratification and SHAP‐based biomarker analysis provide transparent decision ...
Tianle Jie, Datao Xu, Zhifeng Zhou, Bas Van Hooren, Huiyu Zhou, Yi Yuan, Xiangli Gao, Monèm Jemni, Liangliang Xiang, Meizi Wang, Justin Fernandez, Tibor J. Goda, Yaodong Gu   +12 more
wiley   +1 more source

The effects of coronoid fracture fixation on functional outcomes and complication rates following terrible triad injuries of the elbow. [PDF]

Clin Shoulder Elb
Babasiz T, Hockmann JP, Weber M, Ott N, Leschinger T, Müller LP, Rausch V.   +6 more
europepmc   +1 more source

Targeting β2‐Adrenergic Receptor Stability With Lycorine Reveals a Host‐Directed Pathway for Antiviral Defense Against Poxviruses

Advanced Science, EarlyView.
Chronic stress drives autophagy‐mediated β2‐AR degradation, impairing antiviral immunity and promoting poxvirus lethality. Lycorine directly stabilizes β2‐AR to restore host defense, suppress excessive inflammation and improve survival. ABSTRACT Psychological stress is a pervasive yet poorly understood modulator of infectious disease outcomes. Here, we
Xin Zhang, Shuqin Xu, Zixuan Zhang, Chenwen Wan, Xiaoqin Wang, Peihua Wang, Huini Yang, Tianxiao Huang, Yijia Yuan, Faiza Atique, Rui Yang, Yingli He, Zhijun Liu   +12 more
wiley   +1 more source

Availability and gaps in operating theatre structural resources for fracture fixation in Tanzania: a national cross-sectional analysis. [PDF]

BMJ Open
Issa SA, Njambilo GM, Mgisha WR, Mrita FS, Muhamedhussein MS.   +4 more
europepmc   +1 more source

Extraarticular Interfragmentary Fixation of an Irreducible Pipkin Type 1 Fracture Dislocation of the Hip – A Case Report

Introduction: Femoral head fractures occur almost exclusively as a result of a traumatic hip dislocation. Due to the intrinsic anatomical stability of the hip, most of these injuries result from high-energy trauma.
Sachin Kale, Dinesh Kale, Ajit Modak, Sanjay Pratheep, Sahil Kale, Ravindra Bharamgunde   +5 more
core   +1 more source

From Sensing Mechanisms to System Co‐Design: Graphene‐Based Sensors and Readout Circuits

Advanced Science, EarlyView.
This review establishes a unified PS–EQ–RF framework linking graphene sensing mechanisms, native electrical outputs, and output‐specific readout circuits. Voltage‐, current‐, resistance‐, and capacitance‐type sensing systems are systematically classified to guide architecture selection, low‐noise design, system co‐design, and practical integration ...
Jinduo Zhang, Meng Chen, Guanchen Li, Ruifeng Liu, Yingxin Wang, Ziran Zhao   +5 more
wiley   +1 more source

Holding the line: predictors of coronal and sagittal loss of reduction after tibial plateau fracture fixation. [PDF]

Arch Orthop Trauma Surg
Hesmerg MK, Benner JL, Joosse P, Keijser LCM.   +3 more
europepmc   +1 more source

Matrix Stiffness Orchestrates Mesenchymal Stem Cell Lineage Commitment Toward Osteogenesis and Adipogenesis Through the PIEZO1/SP1/STC2 Axis

Advanced Science, EarlyView.
Matrix stiffness directs mesenchymal stem cell lineage commitment through PIEZO1‐dependent activation of the SP1/STC2 pathway. Stiff matrices favor osteogenesis and suppress adipogenesis, whereas the loss of PIEZO1 function impairs early bone formation. STC2 retains lineage‐regulatory activity even when PIEZO1 is inactive.
Shuo Zhang, Siteng Li, Wenzhong Chen, Qingcheng Song, Haiyue Zhao, Peng Wang, Yiran Zhang, Wenquan Liang, Shaowei Zheng, Juan Wang, Wei Chen, Yanbin Zhu, Yingze Zhang   +12 more
wiley   +1 more source

ACSL4‐Dependent Lysosomal Lipid Peroxidation Links WTAP‐Mediated m6A Modification to Intervertebral Disc Degeneration

Advanced Science, EarlyView.
IL‐1β upregulates the protein level of WTAP, which promotes the m6A modification of ACSL4 mRNA in an IGF2BP2‐dependent manner, thereby enhancing its stability. The increased ACSL4 drives lipid peroxidation, leading to lysosomal membrane permeabilization (LMP) and impaired mitophagy, which collectively accelerate intervertebral disc degeneration (IVDD).
Shu Jia, Xu Gao, Laimin Zhu, Haixia Song, Jing Wu, Shang Chen, Sheng Gao, Lu Zhang, Chunyang Meng   +8 more
wiley   +1 more source