Advanced Science, EarlyView.This study reveals that 5'tiRNA‐Gln interacts with hnRNPC to promote IGF1R liquid‐liquid phase separation, which drives ERK1/2 signaling activation, EMT, and breast cancer bone metastasis. These findings highlight a novel mechanism of breast cancer bone metastasis and potential therapeutic target in metastatic breast cancer.
Bingnan Wang +9 more
wiley +1 more source
Fracture Fixation Sequencing in Polyskeletal Trauma: Clinical Experience from a Five-Patient Retrospective Series. [PDF]
J Orthop Case RepCharan SD, Srinivasan SS, Sameer M.
europepmc +1 more source
Vine‐Inspired Soft Robotics: Materials, Actuations, and Emerging Applications
Advanced Science, EarlyView.Vine‐inspired robots grow from the tip, enabling navigation through confined spaces with minimal disturbance. This Review summarizes material and actuation strategies for vine‐inspired growth, key functions including steering, retraction, attachment, branching, and variable stiffness, and emerging applications spanning medical intervention, confined ...
Jiahao Wu +7 more
wiley +1 more source
Serial drilling technique for sequential subtrochanteric femur fracture fixation in pediatric osteopetrosis: a technical report. [PDF]
OTA IntMansour A +9 more
europepmc +1 more source
Advanced Science, EarlyView.This study reports a neutrophil membrane‐encapsulated Pd/hCeO2 nanozyme (PCN) for targeted treatment of perioperative neurocognitive disorders (PND) in aged mice. PCN inhibits glycolysis‐driven microglial activation and neuroinflammation, improves mitochondrial respiration, and maintains blood‐brain barrier integrity and synaptic function, ultimately ...
Lili Huang +17 more
wiley +1 more source
Sea Cucumber‐Inspired Double‐Network Biopolymer Hydrogels for Programmable Soft Machines
Advanced Science, EarlyView.Inspired by the mutable dermis of sea cucumbers, the collagen‐alginate double‐network elastomeric (CoDE) hydrogel achieves programmable, recoverable, and functional mechanical behavior. The CoDE hydrogel mimics the mutable stiffness of the sea cucumber dermis through a densified collagen cryogel scaffold that is secondarily reinforced by a dissipative,
Luo Yan +3 more
wiley +1 more source
Comparing outcomes of acetabular fracture fixation in early career versus experienced orthopaedic trauma surgeons. [PDF]
OTA IntDavidson S +5 more
europepmc +1 more source
Advanced Science, EarlyView.An assembly porous titanium/β‐TCP implant is developed to establish a spatially programmable osteogenic microenvironment for enhanced osseointegration. By decoupling mechanical support from bioactive ion release, localized ionic gradients generated from the β‐TCP module direct osteogenic activity and bone ingrowth toward the porous titanium framework ...
Heng Zhang +5 more
wiley +1 more source
Biomechanical and finite element analysis of a novel annular multi-axial locking plate for patellar fracture fixation. [PDF]
J Orthop Surg ResZou H +5 more
europepmc +1 more source
Spatiotemporal Regulation of Hierarchical Assembly of Hydroxyapatite for Enamel Remineralization
Advanced Science, EarlyView.Biomimetic repair exhibits unique advantages for enamel regeneration compared with conventional clinical treatments. An enzymatic mineralization system (EMS) is developed, where the resulting HAP nanorods hierarchically assemble into a highly ordered structure on the enamel surface through the spatiotemporal modulation of interfacial energies of ...
Zhenhang Tang +15 more
wiley +1 more source