Results 191 to 200 of about 125,598 (296)

The Sirt1‐Piezo1 Axis Promotes Bone Formation and Repair in Mice

open access: yesAdvanced Science, EarlyView.
Piezo1 upregulates in cartilage callus during bone repair, where its deletion impairs ossification and healing in mice, while activation enhances these processes. Sirt1 positively regulates Piezo1 expression and activity to promote osteogenesis and bone repair in mice.
Donghao Gan   +16 more
wiley   +1 more source

A Three‐Phase Electrostatic Clutch with Variable Mechanical Impedance Control for Soft Robotic Systems

open access: yesAdvanced Science, EarlyView.
The research introduces a three‐phase electrostatic (ES) clutch with variable mechanical impedance control, specifically designed to enable continuous and precise friction modulation, thereby reducing both force degradation and oscillatory motion. This method effectively resolves conventional ES clutch issues, such as residual charge accumulation and ...
Dongyoung Lee, Heejin Yu, Joonbum Bae
wiley   +1 more source

Underwater Instant Adhesive Hydrogel Interfaces for Robust Biosensing on Diverse Species

open access: yesAdvanced Science, EarlyView.
An instant underwater adhesion hydrogel interface is constructed via a universal and facile molecular entanglement engineering through a roll‐to‐roll scalable manufacturing protocol, achieving rapid and strong interfacial toughness over 230 J•m−2 within 10 s.
Xueyin Chen   +10 more
wiley   +1 more source

Targeting of the CD161 Inhibitory Receptor Enhances Bone‐Marrow‐Resident Memory CD8+ T‐Cell‐Mediated Immunity against Multiple Myeloma

open access: yesAdvanced Science, EarlyView.
CD161 is identified as a novel inhibitory receptor on bone marrow (BM)‐resident CD8⁺ T cells in multiple myeloma (MM). Through interaction with its ligand CLEC2D, CD161 impairs T‐cell function and promotes immune suppression. Blockade of CD161 restores tissue residency and cytotoxicity of CD8⁺ T cells and enhances chimeric antigen receptor T‐cell (CAR ...
Liwen Wang   +16 more
wiley   +1 more source

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