Results 51 to 60 of about 1,759,920 (268)

Characterization of the microstructural properties that are predictive of regain in strength in phosphate-deficient mice [PDF]

, 2016
Fracture healing occurs in a discrete set of steps, which recapitulates embryonic endochondral bone formation. Pathophysiologies of the fracture healing that prolong the fracture repair or result in non-union may be associated with either environmental ...
Simmons, Erin
core   +1 more source

Age-related changes to macrophage subpopulations and TREM2 dysregulation characterize attenuated fracture healing in old mice. [PDF]

Fracture healing complications increase with age, with higher rates of delayed unions and nonunions and an associated increase in morbidity and mortality in older adults.
Brazina, Sloane, Clark, Daniel, Hsieh, Christine, Marcucio, Ralph, Miclau, Ted, Nakamura, Mary, Park, Sangmin   +6 more
core   +1 more source

Estrogen and raloxifene improve metaphyseal fracture healing in the early phase of osteoporosis. A new fracture-healing model at the tibia in rat [PDF]

, 2008
Background Fracture healing in osteoporosis is delayed. Quality and speed of fracture healing in osteoporotic fractures are crucial with regard to the outcome of patients. The question arises whether established antiosteoporotic drugs can further improve
A Nakajima, BA Rahn, C Li, CC Danielsen, D Seidlova-Wuttke, D. Seidlova-Wuttke, DN Kalu, E Tsiridis, E. K. Stuermer, E. Wenda, EK Stuermer, G Schmidmaier, GA Rodan, H Hatano, H Namkung-Matthai, HM Frost, HM Frost, J Aerssens, J Li, JG Blythe, K. H. Frosch, K. M. Stuermer, KM Stuermer, L Claes, LE Claes, M Miwa, M. Tezval, MC Faugerer, ME Bolander, NF Ray, P Aspenberg, P Klein, P Seebeck, RA Brand, RK Schenk, RM McCann, S. Sehmisch, T Kubo, T Ohishi, T. Rack, TJ Wronski, TJ Wronski, TJ Wronski, UT Iwaniec, W. Wuttke, WR Walsh, XJ Li, Y Cao, YL Hao, Z Peng   +49 more
core   +2 more sources

Fracture healing physiology and the quest for therapies for delayed healing and nonunion

Journal of Orthopaedic Research, 2016
Delayed healing and nonunion of fractures represent enormous burdens to patients and healthcare systems. There are currently no approved pharmacological agents for the treatment of established nonunions, or for the acceleration of fracture healing, and ...
P. Kostenuik, Faisal M Mirza
semanticscholar   +1 more source

Stem cell‐derived exosomes: A promising strategy for fracture healing

Cell Proliferation, 2017
To describe the biological characteristics of exosomes and to summarize the current status of stem cell‐derived exosomes on fracture healing. Meanwhile, future challenges, limitations and perspectives are also discussed.
Zi-Chen Hao, Jun Lu, Shan-zheng Wang, Hao Wu, Yun-tong Zhang, Shuo-gui Xu   +5 more
semanticscholar   +1 more source

Nutritional Aspects of Bone Health and Fracture Healing

Journal of Osteoporosis, 2017
Introduction Fractures are quite common, especially among the elderly. However, they can increase in prevalence in younger ages too if the bone health is not good. This may happen as a result of bad nutrition.
Athanasios Karpouzos, E. Diamantis, Paraskevi Farmaki, S. Savvanis, T. Troupis   +4 more
semanticscholar   +1 more source

Mice with a Heterozygous Lrp6 Deletion Have Impaired Fracture Healing [PDF]

, 2016
Bone fracture non-unions, the failure of a fracture to heal, occur in 10%–20% of fractures and are a costly and debilitating clinical problem. The Wnt/β-catenin pathway is critical in bone development and fracture healing.
Burgers, Travis A., Mason, James J., Vander Moren, Andrew J., Vivanco, Juan F., Williams, Bart O., Zahatnansky, Juraj   +5 more
core   +2 more sources

TRPV1 deletion impaired fracture healing and inhibited osteoclast and osteoblast differentiation

Scientific Reports, 2017
Fracture healing, in which osteoclasts and osteoblasts play important roles, has drawn much clinical attention. Osteoclast deficiency or decreased osteoblast activity will impair fracture healing.
Linhai He, Meng Liu, Yang He, E. Xiao, Lu Zhao, Ting Zhang, Hua-Qian Yang, Yi Zhang   +7 more
semanticscholar   +1 more source

Predictive Model Development to Identify Failed Healing in Patients after Non-Union Fracture Surgery [PDF]

2024 46th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC), Orlando, FL, USA, 2024, pp. 1-4
Bone non-union is among the most severe complications associated with trauma surgery, occurring in 10-30% of cases after long bone fractures. Treating non-unions requires a high level of surgical expertise and often involves multiple revision surgeries, sometimes even leading to amputation.
arxiv   +1 more source

Fracture healing in the elderly: A review.

Maturitas, 2016
Older patients are commonly at a higher risk of experiencing a bone fracture. Complications during fracture healing, including delayed union and non-union, can arise as a result of a multitude of patient and treatment factors. This review describes those factors which contribute to a greater risk of delayed union and non-union with particular reference
B. Foulke, A. Kendal, D. Murray, H. Pandit   +3 more
semanticscholar   +5 more sources