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Macrophages—bone marrow mesenchymal stem cells crosstalk in bone healing
Frontiers in Cell and Developmental Biology, 2023 Bone healing is associated with many orthopedic conditions, including fractures and osteonecrosis, arthritis, metabolic bone disease, tumors and periprosthetic particle-associated osteolysis.
Siyu Fan +10 more
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MedEdPORTAL, 2013 Introduction This resource introduces students to basic concepts related to bone healing. The module is taught in the second half of the first year of our institution's undergraduate medical program.
Lindsay Davidson
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Bone fracture healing in mechanobiological modeling: A review of principles and methods
Bone Reports, 2017 Bone fracture is a very common body injury. The healing process is physiologically complex, involving both biological and mechanical aspects. Following a fracture, cell migration, cell/tissue differentiation, tissue synthesis, and cytokine and growth ...
Mohammad S. Ghiasi +4 more
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Subject-specific multivariate modeling for regenerative rehabilitation of bone healing [PDF]
APL BioengineeringRehabilitation can help promote functional restoration following surgical reconstruction of severe bone injuries, yet prescribed regimens are often conservative due to limited understanding of their impact on healing.
Kylie E. Williams +10 more
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Impaired bone healing upon neutrophil-specific adrenoreceptor beta 2 knockout in non-osteoporotic and osteoporotic mice [PDF]
npj Regenerative MedicineAfter a bone fracture, osteoporotic mice show delayed healing associated with elevated systemic inflammation and increased neutrophil numbers in the early fracture hematoma.
Sandra Dieterich +8 more
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Accelerated Bone Healing via Electrical Stimulation
Advanced SciencePiezoelectric effect produces an electrical signal when stress is applied to the bone. When the integrity of the bone is destroyed, the biopotential within the defect site is reduced and several physiological responses are initiated to facilitate healing.
Jianfeng Sun +4 more
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Journal of Functional Biomaterials, 2022 The tendon-to-bone interface is a special structure connecting the tendon and bone and is crucial for mechanical load transfer between dissimilar tissues.
Haihan Gao +11 more
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Frontiers in Bioengineering and Biotechnology, 2023 At present, anterior cruciate ligament (ACL) reconstruction still has a high failure rate. Tendon graft and bone tunnel surface angiogenesis and bony ingrowth are the main physiological processes of tendon-bone healing, and also the main reasons for the ...
Bin Tian, Ming Zhang, Xin Kang
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Challenges to Improve Bone Healing Under Diabetic Conditions
Frontiers in Endocrinology, 2022 Diabetes mellitus (DM) can affect bone metabolism and the bone microenvironment, resulting in impaired bone healing. The mechanisms include oxidative stress, inflammation, the production of advanced glycation end products (AGEs), etc.
Yiling Chen +4 more
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Microtomographic, histomorphometric, and molecular features show a normal alveolar bone healing process in iNOS-deficient mice along a compensatory upregulation of eNOS and nNOS isoforms [PDF]
Journal of Applied Oral Science, 2023 Inducible nitric oxide synthase (iNOS) is one of the enzymes responsible for the synthesis of nitric oxide (NO), which is an important signaling molecule with effects on blood vessels, leukocytes, and bone cells.
Carolina Fávaro FRANCISCONI +9 more
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