Results 21 to 30 of about 259,590 (261)

In silico Mechano-Chemical Model of Bone Healing for the Regeneration of Critical Defects: The Effect of BMP-2. [PDF]

PLoS ONE, 2015
The healing of bone defects is a challenge for both tissue engineering and modern orthopaedics. This problem has been addressed through the study of scaffold constructs combined with mechanoregulatory theories, disregarding the influence of chemical ...
Frederico O Ribeiro, María José Gómez-Benito, João Folgado, Paulo R Fernandes, José Manuel García-Aznar   +4 more
doaj   +1 more source

External stimulation: A potential therapeutic strategy for tendon-bone healing

Frontiers in Bioengineering and Biotechnology, 2023
Injuries at the tendon-bone interface are very common in the field of sports medicine, and healing at the tendon-bone interface is complex. Injuries to the tendon-bone interface can seriously affect a patient’s quality of life, so it is essential to ...
Shijie Fu, Shijie Fu, Shijie Fu, Yujian Lan, Guoyou Wang, Dingsu Bao, Bo Qin, Qiu Zheng, Huan Liu, Vincent Kam Wai Wong   +9 more
doaj   +1 more source

Research progress in the roles of Notch signaling pathway during fracture healing

Shanghai Jiaotong Daxue xuebao. Yixue ban, 2023
Fracture is the most common large-organ injury in humans. It takes several months or even longer from the onset to the completion of bone reconstruction. In severe cases, delayed healing or even bone discontinuity can occur.
GUO Liqiang, ZHAO Shitian, SHU Bing
doaj   +1 more source

Bone healing in 2016

Clinical Cases in Mineral and Bone Metabolism, 2016
Delayed fracture healing and nonunion occurs in up to 5-10% of all fractures, and can present a challenging clinical scenario for the treating physician. Methods for the enhancement of skeletal repair may benefit patients that are at risk of, or have experienced, delayed healing or nonunion.
John A, Buza, Thomas, Einhorn
openaire   +2 more sources

A Longitudinal Low Dose μCT Analysis of Bone Healing in Mice: A Pilot Study

Advances in Orthopedics, 2014
Low dose microcomputed tomography (μCT) is a recently matured technique that enables the study of longitudinal bone healing and the testing of experimental treatments for bone repair.
Lu-Zhao Di, Vanessa Couture, Élisabeth Leblanc, Yasaman Alinejad, Jean-François Beaudoin, Roger Lecomte, François Berthod, Nathalie Faucheux, Frédéric Balg, Guillaume Grenier   +9 more
doaj   +1 more source

Bioceramics and bone healing

EFORT Open Reviews, 2018
Abstract Calcium phosphates have long been used as synthetic bone grafts. Recent studies have shown that the modulation of composition and textural properties, such as nano-, micro- and macro-porosity, is a powerful strategy to control and synchronize material resorption and bone formation. Biomimetic calcium phosphates, which closely
Ginebra Molins, Maria Pau, Español Pons, Montserrat, Maazouz, Yassine, Bergez, Victor, Pastorino Carraz, David   +4 more
openaire   +4 more sources

In vitro assessment of expansion, mechanical stability, and cohesion across a panel of bone graft scaffolds

Materials Research Express
Background. Over 400 000 spinal fusions are performed annually in the United States, and nonunion has been reported in 5%–45% of cases, with graft selection contributing to this variability.
Douglas C Fredericks, Emily Petersen, Lisa Ferrara, Catherine Olinger, Travis Greenhalgh, Bob Salvat   +5 more
doaj   +1 more source

Comparative Drug Response Profiling in Neuroblastoma Cell Lines and Patient‐Derived Tumor Organoids

Pediatric Blood &Cancer, EarlyView.
ABSTRACT High‐risk neuroblastoma remains a leading cause of pediatric cancer mortality, and improved preclinical models are needed to guide therapeutic developments. We screened seven high‐risk neuroblastoma cell lines and three patient‐derived tumor organoids with 528 compounds alongside bone marrow controls, and compared them with external datasets ...
Krzysztof Wierbiłowicz, Se Whee Sammy Park, Aironas Los, Ernest Liu, Nona Struyf, Tom Erkers, Sören Lehmann, Jan J. Molenaar, Jakob Stenman, Olli Kallioniemi, Päivi Östling, Brinton Seashore‐Ludlow, Kasper Karlsson   +12 more
wiley   +1 more source

Impact of Radiation Therapy on Physical and Psychosocial Health of Adolescents and Young Adults: A Joint Report From the Children's Oncology Group AYA and Radiation Oncology Committees

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Rates of cancer among adolescents and young adults (AYA), age 15–39 years, are increasing. Consequently, radiation oncologists are treating more AYAs who have diagnoses spanning both pediatric and adult practices. Compared to pediatric and older adult patients, AYAs face a unique set of challenges.
Hesham Elhalawani, Rachel K. Peterson, Avani D. Rao, Laurie J. McKenzie, Ahmed Magdy Elmotayam, Leslie Chang, Michael Roth, Susan L. McGovern   +7 more
wiley   +1 more source

Retrospective Analysis of Donor Lymphocyte Infusions in Pediatric Patients With Mixed Chimerism After Hematopoietic Stem Cell Transplantation

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Allogeneic hematopoietic stem cell transplantation (alloHSCT) is an essential therapy for several malignant and nonmalignant diseases, but relapse and graft loss remain the principal threats to its success. Routine monitoring of chimerism and minimal residual disease (MRD) enables early detection of imminent recurrence and guides ...
Carmen Junk, Sebastian Michaelis, Michaela Döring, Thomas Eichholz, Ursula Holzer, Martin Ebinger, Tim Flaadt, Rupert Handgretinger, Peter Lang, Jan Frederic Weller, Markus Mezger   +10 more
wiley   +1 more source